Results 31 to 40 of about 6,716 (130)

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1499-1511, December 2025.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

A Population Pharmacokinetic Approach to Understand the Effect of Efavirenz on CYP3A Activity in Healthy Volunteers Using Midazolam as a Probe

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 12, Page 2095-2106, December 2025.
ABSTRACT Efavirenz induces and inhibits multiple drug‐metabolizing enzymes, contributing to significant drug–drug interactions. This study quantified the impact of multiple doses of efavirenz on CYP3A activity via midazolam metabolism using a population pharmacokinetic approach.
Kimberly S. Collins, Blessed W. Aruldhas, Ingrid F. Metzger, Jessica B. L. Lu, Michael A. Heathman, Sara K. Quinney, Zeruesenay Desta   +6 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Nuclear hormone receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S242-S258, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, John A. Cidlowski, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laurel Coons, Peter J. Fuller, Kenneth S. Korach, Donald P. McDonell, Robert Oakley, Sarah Radi, Rachid Safi, Frances Sladek, Morag J. Young   +20 more
wiley   +1 more source

Environmental Microbial Cues Alter Embryonic Development and Stress Responses in Vertebrates: Insights From the Zebrafish (Danio rerio) Model

Molecular Ecology, Volume 34, Issue 24, December 2025.
ABSTRACT Host‐microbiome interactions shape key physiological processes, including bioenergetics, neurodevelopment and xenobiotic metabolism, and strongly influence the ecological fitness of the host. However, our understanding of host‐microbiome interactions is primarily derived from post‐embryonic free‐living life stages, when the organism is in ...
Emily M. Green, Akila Harishchandra, Colin R. Lickwar, Yeon Ji Kim, John F. Rawls, Richard T. Di Giulio, Nishad Jayasundara   +6 more
wiley   +1 more source

The assessment for potential thyroid‐mediated endocrine disruption in amphibians: Clarification on the use of new methods and on the interpretation of changes in thyroid histology

EFSA Journal, Volume 23, Issue 12, December 2025.
Abstract Amphibians (specifically Xenopus laevis) are used as the model species to assess potential endocrine‐disrupting properties in non‐mammalian species through thyroid modality. The amphibian metamorphosis assay is the most frequently available test.
European Food Safety Authority (EFSA), Lisa Baumann, Alice Baynes, Susanne Hougaard Bennekou, Kevin Crofton, Zhichao Dang, Sigmund Degitz, Jean‐Baptiste Fini, Mary Gilbert, Henrik Holbech, Andrea Terron, Majorie Van Duursen, Emily McVey, Maria Arena, Aude Kienzler, Simone Rizzuto, Laura Villamar Bouza, Martin Wilks   +17 more
wiley   +1 more source

The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast

Animal Models and Experimental Medicine, Volume 8, Issue 11, Page 1997-2007, November 2025.
The flow diagram outlines the chemical induction of breast tumors through a single intraperitoneal dose of MNU. Tumor development was assessed using ultrasound and clinical examination. After 14 weeks, mammary tissue was collected and histologically analyzed to evaluate structural similarities between sows and humans, the carcinogenic potential of MNU,
Claudia Elizabeth Vera‐Tizatl, Arturo Vera‐Hernández, Lorenzo Leija‐Salas, Marco Antonio Vega‐López, María del Carmen Ramírez‐Estudillo, German Isauro Garrido Fariña, Adriana Leticia Vera‐Tizatl   +6 more
wiley   +1 more source

Liver–Microbiome Crosstalk Mediates the Protective Effects of Artemisinin in Clostridium perfringens Models

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
Artemisinin mitigates Clostridium perfringens infection in mice and rabbits by modulating gut–liver crosstalk, leading to restored intestinal morphology, balanced microbiota composition and improved immunometabolic profiles. ABSTRACT Clostridium perfringens is a multi‐host opportunistic pathogen whose plasmid‐encoded toxins cause gas gangrene, necrotic
Haodong Han, Youhao Li, Lili Wang, Zhuoya Jin, Wenqian Zhou, Bing Zhang, Can Jia, Weiqi Zhang, Yuxin Wang, Li Qiu, Song Bing, Shuhui Wang, Zhanjun Ren   +12 more
wiley   +1 more source

Characterization of Drug–Drug Interactions for Remdesivir, an Intravenous Antiviral for SARS‐CoV‐2, in Healthy Participants

Clinical and Translational Science, Volume 18, Issue 11, November 2025.
ABSTRACT Remdesivir is an intravenous antiviral approved worldwide for the treatment of COVID‐19 in adults and children. Remdesivir, as a prodrug inhibitor of RNA polymerase, undergoes intracellular activation to form the active metabolite along with 2 inactive circulating metabolites, GS‐704277 and GS‐441524. Based on drug–drug interaction (DDI) risks
Jack Chang, Aryun Kim, Rita Humeniuk, Naveed A. Shaik, Helen Winter, Chi‐Chi Peng, Deqing Xiao, Mazin Abdelghany, Joe Llewellyn, Santosh Davies, Kandace Golden, Shuguang Chen, Robert H. Hyland, Luzelena Caro   +13 more
wiley   +1 more source

The effect of pregnane X receptor (PXR)‐mediated CYP3A induction on acetaminophen hepatotoxicity

The FASEB Journal, 2007
Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the U.S. Cytochromes P450 CYP2E1, CYP1A2, and CYP3A4 have all been implicated in formation of the reactive intermediate of APAP, and thus can contribute to APAP hepatotoxicity. The nuclear pregnane X receptor (PXR) plays a critical role in CYP3A regulation
XIAOCHAO MA, CHI CHEN, Yatrik Shah, Keiichirou Morimura, Kristopher W. Krausz, Jeffrey R. Idle, FRANK J GONZALEZ   +6 more
openaire   +1 more source

Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway. [PDF]

CNS Neurosci Ther, 2023
Xuan LN, Hu ZX, Jiang ZF, Zhang C, Sun XW, Ming WH, Liu HT, Qiao RF, Shen LJ, Liu SB, Wang GY, Wen L, Luan ZL, Yin J.   +13 more
europepmc   +1 more source