Results 81 to 90 of about 6,716 (130)

Indole Propionic Acid Regulates Gut Immunity: Mechanisms of Metabolite-Driven Immunomodulation and Barrier Integrity. [PDF]

J Microbiol Biotechnol
Ren T, Li D, Sun F, Pan L, Wang A, Li X, Bao Y, Zhang M, Zheng F, Yue H.   +9 more
europepmc   +1 more source

Commiphora myrrha resin extract-modulated cytochrome P-450 2C9 enzyme expression in cultured Hep G2 cells is associated with resin extract-derived metabolites binding to Pregnane X receptor. [PDF]

BMC Complement Med Ther
Alsharidah A, Alehaideb Z, Alghamdi SS, Suliman RS, Althenayyan S, Almourfi F, Hazazi B, Almogren A, Tuwaijri AA, Boudjelal M, Alkhuriji A, Matou-Nasri S.   +11 more
europepmc   +1 more source

From gut to clot: metabolic control of thrombosis by microbiota. [PDF]

Life Metab
Life Metabolism Editorial Team.
europepmc   +1 more source

Lithocholic acid ameliorates ulcerative colitis via the PXR/TLR4/NF-κB/NLRP3 signaling pathway and gut microbiota modulation. [PDF]

Cell Mol Life Sci
Liu Y, Gao J, Chen L, Chen Y, Jiang J, Chen H, Ma L.   +6 more
europepmc   +1 more source

Lithocholic Acid Species: Metabolism, Signaling Pathways, and Clinical Significance in Enterohepatic Diseases. [PDF]

Int J Mol Sci
Leng L, Zhou G, Liu A, Wang H, Ni Y.
europepmc   +1 more source

Intestinal amino acid metabolic response and its roles in inflammatory bowel disease. [PDF]

Cell Commun Signal
Niu Y, Wang F, Liu C, Liu Z, Hu X.
europepmc   +1 more source

The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells. [PDF]

Front Endocrinol (Lausanne)
Martinot E, Holota H, de Haze A, Beaudoin C, Volle DH.   +4 more
europepmc   +1 more source

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Pregnane X receptor (PXR) – a contributor to the diabetes epidemic?

dmdi, 2013
Abstract Pregnane X receptor (PXR), a ligand-activated nuclear receptor, was originally identified as a regulator of drug and bile acid metabolism. Studies in experimental animals and humans within the last decade have revealed PXR as a regulator of energy metabolism repressing gluconeogenesis and hepatic lipid oxidation. The most recent
Janne, Hukkanen, Jukka, Hakkola, Jaana, Rysä   +2 more
openaire   +3 more sources

(‐)‐Epicatechin Activates Pregnane X Receptor (PXR) in Skeletal Muscle

The FASEB Journal, 2020
(‐)‐Epicatechin (EC) is a flavanol that has shown numerous biological effects such as: decrease cardiovascular dysfunction risk, metabolism regulation, induction of skeletal muscle (SkM) cells differentiation among others.
Miguel Ortiz, Nayelli Najera, Francisco Villarreal, Guillermo Ceballos   +3 more
openaire   +1 more source

Attenuating pregnane X receptor (PXR) activation: A molecular modelling approach

Xenobiotica, 2007
Recent studies have demonstrated that the pregnane X receptor (PXR) is a key regulator of cytochromes P450 3A (e.g. CYP3A4 in human) gene expression. As a result, activation of PXR may lead to CYP3A4 protein over-expression. Because induction of CYP3A4 could result in clinically important drug drug interactions, there has been a great interest in ...
Y D, Gao, S H, Olson, J M, Balkovec, Y, Zhu, I, Royo, J, Yabut, R, Evers, E Y, Tan, W, Tang, D P, Hartley, R T, Mosley   +10 more
openaire   +2 more sources