Results 91 to 100 of about 8,350 (160)

Bioinformatic research of the gene "pregnane X receptor" (PXR) homologues in marine invertebrates

, 2018
The xenobiotic detoxification enzymes are regulated, in mammals and other animals, by a specific group of nuclear receptors. In particular pregnane X receptor (PXR) has shown incredible versatility in recognizing a broad range of xenobiotics and natural ...
Ribeiro, Daniel, Martins, José C., Campos, Alexandre   +2 more
core  

Differential expression of the nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) for grading dysplasia in patients with Barrett’s oesophagus

, 2011
Aims: To investigate expression of nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) as a diagnostic tool to improve grading of dysplasia in Barrett's oesophagus patients.
Katinka P M van Zoest, Winkel, Anouk, van der Laan, Luc; id_orcid, Herman van Dekken, Moons, Leon, van Dekken, Herman, Kuipers, Ernst, van Dekken, H (Herman), van de Winkel, Anouk, Anouk van de Winkel, van Der Laan, Luc, Ernst J Kuipers, Leon M G Moons, Luc J W van der Laan, van Zoest, KPM, van Zoest, Katinka, Moons, Leon M, Kuipers, Ernst J   +17 more
core   +1 more source

Identification of Novel Transcription Start Sites and Distinct Proximal Promoter Regions for Pregnane X Receptor (PXR) Isoforms PXR 1 and PXR 2

, 2008
TOMPKINS, LESLIE MEREDITH. Identification of Novel Transcription Start Sites and Alternative Proximal Promoters for Pregnane X Receptor (PXR) Isoforms PXR 1 and PXR 2. (under the direction of Dr. Robert C. Smart and Dr. Andrew D.
Tompkins, Leslie Meredith
core  

Pregnane X Receptor Activation in Liver Macrophages Protects against Endotoxin‐Induced Liver Injury

Advanced Science
Endotoxemia‐related acute liver injury has a poor prognosis and high mortality, and macrophage polarization plays a central role in the pathological process.
Tingting Zhao, Guoping Zhong, Ying Wang, Renjie Cao, Shaofei Song, Yuan Li, Guohui Wan, Haiyan Sun, Min Huang, Huichang Bi, Yiming Jiang   +10 more
doaj   +1 more source

Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease

Mediators of Inflammation, 2019
Nuclear receptors (NRs) are ligand-dependent transcription factors that regulate the transcription of target genes. Previous epidemiological and genetic studies have documented the association of NRs with the risk of inflammatory bowel disease (IBD ...
Longgui Ning, Xinhe Lou, Fenming Zhang, Guoqiang Xu   +3 more
doaj   +1 more source

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

, 2000
Transcription of genes encoding cytochrome P 450 3A (CYP3A) monooxygenases is induced by a variety of xenobiotics and natural steroids. There are marked differences in the compds. that induce CYP3A gene expression between species. Recently, the mouse and
Linda B. Moore, Edward L. LeCluyse, Millard H. Lambert, Stacey A. Jones, Jones, Stacey A., Nicholas C. O. Tomkinson, Kliewer, Steven A., LeCluyse, Edward L., Tomkinson, Nicholas C. O., G. Bruce Wisely, Shenk, Jennifer L., Moore, John T., Wisely, G. Bruce, Moore, Linda B., Geraldine A. Hamilton, John T. Moore, Jennifer L. Shenk, Steven A. Kliewer, David D. McKee, Lambert, Millard H., Timothy M. Willson, Hamilton, Geraldine A., McKee, David D., Willson, Timothy M.   +23 more
core   +1 more source

Identification of novel pregnane X receptor (PXR) agonists by In silico and biological activity analyses and reversal of cigarette smoke-induced PXR downregulation. [PDF]

Biochem Biophys Res Commun, 2021
Reddy RT, Nyunoya T.
europepmc   +1 more source

Investigating novel actions of the Pregnane X Receptor (PXR) using Berberine Chloride as a non-canonical ligand

, 2014
The pregnane X receptor (PXR) is a nuclear receptor primarily found in the liver and intestinal tissues. It has a major role in the detoxification of xenobiotics and endobiotics via the up-regulation of genes coding for drug metabolising enzymes (DMEs ...
Callum Allison (572909)
core   +1 more source

Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse

Oncogenesis
Tumor recurrence is frequently attributed to drug-tolerant cancer cells. We previously demonstrated that downregulation of the Pregnane X Receptor (PXR, NR1I2) reduces chemoresistance and prevents colorectal cancer recurrence in xenograft mouse models ...
Lucile Bansard, Guillaume Laconde, Vanessa Delfosse, Tiphaine Huet, Margaux Ayeul, Emilie Rigal, Quentin Donati, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Luc Brunel, Baptiste Legrand, Alain Chavanieu, Anthony R. Martin, Julie Pannequin, William Bourguet, Muriel Amblard, Jean Marc Pascussi   +16 more
doaj   +1 more source

Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.

PLoS ONE, 2015
Steroid and xenobiotic receptor (SXR) and its murine ortholog, pregnane X receptor (PXR), are nuclear receptors that are expressed at high levels in the liver and the intestine where they function as xenobiotic sensors that induce expression of genes ...
Kotaro Azuma, Stephanie C Casey, Tomohiko Urano, Kuniko Horie-Inoue, Yasuyoshi Ouchi, Bruce Blumberg, Satoshi Inoue   +6 more
doaj   +1 more source