Results 111 to 120 of about 8,350 (160)

Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXRα) and Pregnane X Receptor (PXR). [PDF]

Evid Based Complement Alternat Med, 2019
Tai TS, Tien N, Shen HY, Chu FY, Wang CCN, Lu CH, Yu HI, Kung FP, Chuang HH, Lee YR, Chang HY, Lim YP.   +11 more
europepmc   +1 more source

Pregnane X receptor (PXR) as a prognostic marker and therapeutic target in kidney renal clear cell carcinoma (KIRC) via AMPK pathway regulation. [PDF]

Sci Rep
Hu WJ, Liu M, Bao YN, Su BW, Sui X, Cui XH, Wang GY, Wen L, Wen RK, Wang WH, Yang HX, Luan ZL.   +11 more
europepmc   +1 more source

Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation. [PDF]

ChemMedChem, 2018
Narayanan B, Lade JM, Heck CJS, Dietz KD, Wade H, Bumpus NN.   +5 more
europepmc   +1 more source

A Combined Approach for Rapid Dereplication of Herb-Drug Interaction Causative Agents in Botanical Extracts-A Molecular Networking Strategy To Identify Potential Pregnane X Receptor (PXR) Modulators in Yohimbe. [PDF]

ACS Omega
Annam SCVAR, Neal WM, Pandey P, Avula B, Katragunta K, Husain I, Khan SI, Koturbash I, Gurley BJ, Khan IA, Chittiboyina AG.   +10 more
europepmc   +1 more source

Rifaximin, a pregnane X receptor (PXR) activator regulates apoptosis in a murine model of breast cancer. [PDF]

RSC Adv, 2018
Gautam S, Singh P, Singh M, Roy S, Rawat JK, Yadav RK, Devi U, Gupta PS, Saraf SA, Kaithwas G.   +9 more
europepmc   +1 more source

Pregnane X receptor expression in human pancreatic adenocarcinoma: Associations with clinicopathologic parameters, tumor proliferative capacity, patients' survival, and retinoid x receptor expression

, 2015
Objectives: Pregnane X receptor (PXR) has been involved in human malignancy, either by directly affecting carcinogenesis or by inducing drugdrug interactions and chemotherapy resistance.
Kouraklis, G., Zizi-Serbetzoglou, A., Patsouris, E., Alexandrou, P., Koutsounas, I., Giaginis, C., Theocharis, S.   +6 more
core  

Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists.

, 2014
Pregnane X receptor (PXR), a member of the NR1I nuclear receptor family, acts as a xenobiotic sensor and a paramount transcriptional regulator of drug-metabolizing enzymes and transporters.
Hodnik Ž, Peterlin Mašič L, FIORUCCI, Stefano, Smodiš D, Kikelj D., Tomašić T, D'AMORE, CLAUDIO   +6 more
core  

The pregnane X receptor (PXR) and the nuclear receptor corepressor 2 (NCoR2) modulate cell growth in head and neck squamous cell carcinoma. [PDF]

PLoS One, 2018
Rigalli JP, Reichel M, Reuter T, Tocchetti GN, Dyckhoff G, Herold-Mende C, Theile D, Weiss J.   +7 more
europepmc   +1 more source

Hide and seek: targeting nuclear receptor PXR with inhibitors and PROTACs to improve drug efficacy and safety. [PDF]

Expert Opin Ther Targets
Huber AD, Chen T.
europepmc   +1 more source

Sustained Drug-Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone-Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide. [PDF]

Case Rep Oncol Med
Mimura Y, Sanda T, Unno R, Furukawa Y, Shizu R, Motokatsu K, Tashiro Y, Tasaki Y, Sugiyama Y, Yasujima T, Naiki T, Horita Y, Hotta Y, Yuasa H, Yoshinari K, Yasui T, Iida S, Furukawa-Hibi Y.   +17 more
europepmc   +1 more source