Results 101 to 110 of about 8,350 (160)

New aspects of pregnane X receptor function and regulation [PDF]

, 2018
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Lucie Hyršová, MSc. First Supervisor: doc. PharmDr. František Trejtnar, CSc. Consultant: prof. PharmDr. Petr Pávek, PhD.
Hyršová, Lucie
core  

B3galt5 functions as a PXR target gene and regulates obesity and insulin resistance by maintaining intestinal integrity

Nature Communications
Pregnane X receptor (PXR) has been reported to regulate glycolipid metabolism. The dysfunction of intestinal barrier contributes to metabolic disorders. However, the role of intestinal PXR in metabolic diseases remains largely unknown. Here, we show that
Jinhang Zhang, Ya Huang, Hong Li, Pengfei Xu, Qinhui Liu, Yang Sun, Zijing Zhang, Tong Wu, Qin Tang, Qingyi Jia, Yan Xia, Ying Xu, Xiandan Jing, Jiahui Li, Li Mo, Wen Xie, Aijuan Qu, Jinhan He, Yanping Li   +18 more
doaj   +1 more source

Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR)

, 2010
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) regulate xenobiotic sensing and metabolism through interactions with multiple exogenous and endogenous chemicals.
Ann M. Dring, Anderson, Linnea E., Laura D. Hamel, Stoner, Matthew A., Matthew A. Stoner, Dring, Ann M., Linnea E. Anderson, Hamel, Laura D.   +7 more
core   +1 more source

Structural Model Reveals Key Interactions in the Assembly of the Pregnane X Receptor/Corepressor Complex Running Title: Molecular Dynamics of PXR-SMRT Interactions

, 2020
The human pregnane X receptor (PXR), also known as steroid and xenobiotic receptor (SXR), is a member of the orphan nuclear receptors and mediates the mammalian xenobiotic response with broad specificity and implications for drug clearance.
Ching Y Wang, J Don Chen, Ph.D William J Welsh, Corresponding Author) W J W, Chia W Li, William J Welsh   +5 more
core   +1 more source

CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae. [PDF]

Toxicol Sci, 2020
Salanga MC, Brun NR, Francolini RD, Stegeman JJ, Goldstone JV.   +4 more
europepmc   +1 more source

Pregnane X receptor protects against age-related bone loss in males via PI3K/Akt-mediated inhibition of apoptosis

Cell Death Discovery
The pregnane X receptor (Pxr) regulates metabolism and inflammation, but its roles in bone homeostasis remain elusive. This study demonstrates that Pxr deficiency in bones induces osteoporotic phenotypes, with reduced trabecular bone mass, impaired ...
Shangzhi Li, Yu Xu, Wenpeng Xu, Dingxin Zhang, Xiangyu Lin, Peijie Hu, Haipeng Si   +6 more
doaj   +1 more source

An investigation of Cytochrome P450 function in human cell Lines for potential use in a bioartificial liver device

, 2010
Bioartificial Liver Devices (BAL) could provide hepatic function in patients with liver failure awaiting transplantation or liver regeneration. Certain BALs use human hepatoblastoma-derived HepG2 cells that can perform many hepatocyte specific ...
Thomas, A.
core  

Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.)

, 2013
Chicory (Cichorium intybus) has been shown to induce enzymes of pharmacokinetic relevance (cytochrome P450; CYP). The aim of this study was to investigate the effects of selected secondary plant metabolites with a global extract of chicory root, on the ...
Ekstrand, Bo, Klausen, Christina Lindgaard, Rasmussen, Martin Krøyer   +2 more
core   +1 more source

The impact of pregnane X receptor activation on liver fibrosis

, 2006
The PXR (pregnane X receptor) is a nuclear receptor transcription factor that is activated by a range of endobiotics and xenobiotics. The activated PXR modulates the transcription of genes in hepatocytes (the main functional cell of the liver) associated
Wright MC
core  

S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury

JCI Insight
Drug-induced liver injury (DILI), especially acetaminophen overdose, is the leading cause of acute liver failure. Pregnane X receptor (PXR) is a nuclear receptor and the master regulator of drug metabolism.
Qi Cui, Tingting Jiang, Xinya Xie, Haodong Wang, Lei Qian, Yanyan Cheng, Qiang Li, Tingxu Lu, Qinyu Yao, Jia Liu, Baochang Lai, Chang Chen, Lei Xiao, Nanping Wang   +13 more
doaj   +1 more source