Results 81 to 90 of about 8,350 (160)

Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg, Jesus M. Banales, Gideon Hirschfield, Palak Trivedi, Edward E. Cable, Charles A. McWherter, Andrew N. Billin, Daria B. Crittenden, Grant Budas   +8 more
wiley   +1 more source

PXR is a target of (-)-epicatechin in skeletal muscle

Heliyon, 2020
(-)-Epicatechin (EC) is a flavanol that has shown numerous biological effects such as: decrease risk of cardiovascular dysfunction, metabolism regulation, skeletal muscle (SkM) performance improvement and SkM cells differentiation induction, among others.
Miguel Ortiz-Flores, Andrés Portilla-Martínez, Francisco Cabrera-Pérez, Nayelli Nájera, Eduardo Meaney, Francisco Villarreal, Javier Pérez-Durán, Guillermo Ceballos   +7 more
doaj   +1 more source

Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells

Marine Drugs, 2012
Pregnane X receptor (PXR) has been reported to regulate the expression of drug-metabolizing enzymes, such as the cytochrome P450 3A (CYP3A) family and transporters, such as multiple drug resistance 1 (MDR1). Fucoxanthin, the major carotenoid in brown sea
Miao-Lin Hu, Cheng-Ling Liu, Yun-Ping Lim   +2 more
doaj   +1 more source

Diethylstilbestrol-scaffold-based pregnane X receptor modulators

, 2015
Due to its function as a regulator of drug-metabolizing enzymes and transporters, pregnane X receptor (PXR) represents an important factor involved in drug metabolism.
Smodiš, D, Hodnik, Ž, FIORUCCI, Stefano, Kikelj, D., Tomašič, T, D'AMORE, CLAUDIO, Mašič, Lp   +6 more
core   +1 more source

Pregnane X Receptor Signaling Pathway and Vitamin K: Molecular Mechanisms and Clinical Relevance in Human Health

Cells
This review explores the likely clinical impact of Pregnane X Receptor (PXR) activation by vitamin K on human health. PXR, initially recognized as a master regulator of xenobiotic metabolism in liver, emerges as a key regulator influencing intestinal ...
Jeff L. Staudinger, Avina Mahroke, Gauri Patel, Cole Dattel, Sahana Reddy   +4 more
doaj   +1 more source

Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor.

PLoS ONE, 2014
The nuclear receptors and xenosensors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) induce the expression of xenobiotic metabolizing enzymes and transporters, which also affects various endobiotics.
Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn, Leszek Wojnowski, Björn Windshügel   +6 more
doaj   +1 more source

Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity

, 2009
Acetaminophen (APAP) is safe at therapeutic levels but causes hepatotoxicity via N-acetyl-p-benzoquinone imine-induced oxidative stress upon overdose. To determine the effect of human (h) pregnane X receptor (PXR) activation and CYP3A4 induction on APAP ...
Ma, Xiaochao, Cheng, Jie, Krausz, Kristopher W, Gonzalez, Frank J, Idle, Jeffrey R   +4 more
core   +1 more source

Phosphorylation Modulates the Coregulatory Protein Exchange of the Nuclear Receptor Pregnane X Receptor

, 2020
The pregnane X receptor (PXR), or nuclear receptor (NR) 1I2, is a ligand-activated NR superfamily member that is enriched in liver and intestine in mammals.
Shen, Xunan, Agbas, Emre, Cameron-Carter, Hadley, Tompkins, Brandon, Staudinger, Jeff, Cui, Wenqi   +5 more
core   +1 more source

Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis [PDF]

, 2019
The pregnane X receptor (PXR) is a nuclear receptor (NR), involved in the detoxification of xenobiotic compounds. Recently, its presence was reported in the human vasculature and its ligands were proposed to exhibit anti-atherosclerotic effects.
Holbrook, LM, Crescente, M, Unsworth, AJ, Stainer, Alex R., Crescente, Marilena, Unsworth, Amanda J., Sahli, Khaled A., Stainer, AR, Sahli, KA, AlOuda, SK, Flora, Gagan D., Holbrook, Lisa-Marie, Sage, T, Flora, GD, Alouda, Sarah K., Holbrook, L-M, Sasikumar, Parvathy, Sage, Tanya, Gibbins, JM, Gibbins, Jon M., Sasikumar, P   +20 more
core   +1 more source

The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model

Nature Communications
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are closely related nuclear receptors with overlapping regulatory functions in xenobiotic clearance but distinct roles in endobiotic metabolism.
Jan Dusek, Ivana Mejdrová, Klára Dohnalová, Tomas Smutny, Karel Chalupsky, Maria Krutakova, Josef Skoda, Azam Rashidian, Ivona Pavkova, Kryštof Škach, Jana Hricová, Michaela Chocholouskova, Lucie Smutna, Rajamanikkam Kamaraj, Miloš Hroch, Martin Leníček, Stanislav Mičuda, Dirk Pijnenburg, Rinie van Beuningen, Michal Holčapek, Libor Vítek, Magnus Ingelman-Sundberg, Oliver Burk, Thales Kronenberger, Radim Nencka, Petr Pavek   +25 more
doaj   +1 more source