Results 21 to 30 of about 668 (155)

Biomarker Composition of Some Oil Seeps from West Sulawesi, Indonesia

Indonesian Journal on Geoscience, 2018
DOI: 10.17014/ijog.5.3.211-220A suite of oil seep samples collected from the Lariang and Karama Basins, West Sulawesi, Indonesia, have been analyzed using GC and GCMS techniques.
Yarra Sutadiwiria, Ahmad Helman Hamdani, Yoga Andriana Sendjaja, Iyan Haryanto, Yeftamikha Yeftamikha   +4 more
doaj   +1 more source

A review on Adenium obesum: A potential endemic medicinal plant in Oman

Beni-Suef University Journal of Basic and Applied Sciences, 2018
Medicinal plants have played a vital role in the treatment of various human diseases and development of the society since the ancient times. Medicinal plants are the only safe sources for new drugs to treat curable and incurable diseases.
Associate Professor Dr. Md. Amzad Hossain
doaj   +1 more source

Functional evolution of the pregnane X receptor [PDF]

Expert Opinion on Drug Metabolism & Toxicology, 2006
The pregnane X receptor (PXR; NR1I2) is a nuclear hormone receptor (NR) that transcriptionally regulates genes encoding transporters and drug-metabolising enzymes in the liver and intestine. PXR activation leads to enhanced metabolism and elimination of xenobiotics and endogenous compounds such as hormones and bile salts.
Manisha, Iyer, Erica J, Reschly, Matthew D, Krasowski   +2 more
openaire   +2 more sources

Synthesis of 6,19-Sulfamidate Bridged Pregnanes

The Journal of Organic Chemistry, 2005
Conformationally restrained substituted pregnane-20-one derivatives were obtained by an intramolecular nitrene addition onto a C-5/C-6 double bond involving a tethered C-19 sulfamoyl moiety. The resulting aziridine underwent regioselective nucleophilic ring opening at C-5 at room temperature with cyanide, fluoride, and acetate.
Duran, Fernando Javier, Ghini, Alberto Antonio, Dauban, Philippe, Dodd, Robert H., Burton, Gerardo   +4 more
openaire   +3 more sources

Non-invasive assessment of the reproductive cycle in free-ranging female African elephants (Loxodonta africana) treated with a gonadotropin-releasing hormone (GnRH) vaccine for inducing anoestrus

Reproductive Biology and Endocrinology, 2012
Background In southern Africa, various options to manage elephant populations are being considered. Immunocontraception is considered to be the most ethically acceptable and logistically feasible method for control of smaller and confined populations. In
Benavides Valades Gabriela, Ganswindt Andre, Annandale Henry, Schulman Martin L, Bertschinger Henk J   +4 more
doaj   +1 more source

Ring a Aromatic Steroids in the Pregnane Series

Journal of Chemical Research, 2006
4-Methylpregna-1,3,5(10)-trien-20-one and 4-methylpregna-1,3,5(10),16-tetraen-20-one have been obtained by a dienol: benzene type of rearrangement of 5α,6α-epoxypregnanes possessing a further double bond equivalent on ring A. The crystal structure of 4-methyl-19-norpregna-1,3,5(10)-trien-20-one is reported.
Hanson, James R., Malay, Aslihan, UYANIK, CAVİT, Tiryakioglu, Serpil, Hitchcock, Peter B.   +4 more
openaire   +2 more sources

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

Advanced Science, EarlyView.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu, Caiyan Lin, Lijie Zhang, Xue Jiang, Huawen Li, Yangzhe Wu   +5 more
wiley   +1 more source

Progestogen use and the risk of intracranial meningioma: a systematic review and meta-analysisResearch in context

EClinicalMedicine
Summary: Background: Meningiomas are the most common primary brain tumours in adults. Concerns have emerged about a possible link between progestogen use and intracranial meningioma; we assessed this association.
Benoit Hudelist, Alexandre Roux, Emmanuelle Huet-Mignaton, Isabelle Dufaure-Gare, Alessandro Moiraghi, Angela Elia, Maimiti Seneca, Corentin Provost, Joseph Benzakoun, Alexandre Gehanno, Catherine Oppenheim, Marc Zanello, Johan Pallud   +12 more
doaj   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source