Results 21 to 30 of about 661 (149)

Pregnanes and Pregnane Glycosides from Hoya carnosa.

open access: yesChemical and Pharmaceutical Bulletin, 1999
Eleven pregnanes were isolated from the hydrolysate of the CHCl3 extract fractionated from the caules of Hoya carnosa. Among these, six pregnanes, including 19-acetoxydigipurpurogenin II, were new, and their structures were elucidated. The structures of twenty new pregnane tetraosides and pentaosides, named hoyacarnosides A-T, besides three known ones ...
ABE, Fumiko   +5 more
openaire   +3 more sources

Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoreductase and 3α(β)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells

open access: yesBMC Cancer, 2003
Background Recent observations indicate that human tumorous breast tissue metabolizes progesterone differently than nontumorous breast tissue. Specifically, 5α-reduced metabolites (5α-pregnanes, shown to stimulate cell proliferation and detachment) are ...
Lewis Michael J, Wiebe John P
doaj   +1 more source

Pregnane and pregnane glycosides from Trachelospermum liukiuense.

open access: yesChemical and Pharmaceutical Bulletin, 1989
Cortexone and three new bisdesmosidic glycosides of teikagenin were isolated from Trachelospermum liukiuense, together with five glycosides already known in Trachelospermum asiaticum. The new glycosides have D-digitalose linked to the 20-OH as well as to the 3-OH.
ABE, Fumiko, YAMAUCHI, Tatsuo
openaire   +2 more sources

Patterns of endogenous steroids in apathetic refugee children are compatible with long-term stress

open access: yesBMC Research Notes, 2012
Background During the last few years, a number of children of asylum applicants in Sweden developed an apathetic or unconscious state. The syndrome was perceived as new, and various explanations were advanced such as factitious disorder, intoxication, or
Söndergaard Hans   +4 more
doaj   +1 more source

In vitro and in vivo antidiabetic potential of extracts and a furostanol saponin from Balanites aegyptiaca

open access: yesPharmaceutical Biology, 2017
Context: Balanites aegyptiaca Del. (Zygophyllaceae) fruits are well-known antidiabetic drug in Egyptian folk medicine. Nevertheless, its mechanism of action is still unclear.
Shahira Mohammed Ezzat   +2 more
doaj   +1 more source

Pregnane and Pregnane Glycosides from the Malagasy Plant, Cynanchum aphyllum.

open access: yesChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Kanchanapoom, Tripetch   +4 more
openaire   +3 more sources

Synthesis of Pregnane Derivatives, Their Cytotoxicity on LNCap and PC-3 Cells, and Screening on 5α-Reductase Inhibitory Activity

open access: yesMolecules, 2009
A series of epoxy- and/or 20-oxime pregnanes were synthesized from commercially available pregnenolone. Compounds 1, 3, 7, 8 and 11-13 were evaluated for cytotoxicity activity towards LNCaP (androgen-dependent) and PC-3 (androgenindependent) prostate ...
Sujeong Kim, Eunsook Ma
doaj   +1 more source

Menopausal hormone therapy and venous thromboembolism

open access: yesMenopause Review, 2014
Menopausal hormone therapy (MHT) is the most effective method of treating vasomotor symptoms and other climacteric symptoms related to estrogen deficiency in peri- and postmenopausal period.
Małgorzata Bińkowska
doaj   +1 more source

A review on Adenium obesum: A potential endemic medicinal plant in Oman

open access: yesBeni-Suef University Journal of Basic and Applied Sciences, 2018
Medicinal plants have played a vital role in the treatment of various human diseases and development of the society since the ancient times. Medicinal plants are the only safe sources for new drugs to treat curable and incurable diseases.
Associate Professor Dr. Md. Amzad Hossain
doaj   +1 more source

Role of aldo-keto reductase enzymes in mediating the timing of parturition

open access: yesFrontiers in Pharmacology, 2012
A better understanding of the mechanisms underlying the initiation of parturition would provide an important step towards the development of more effective therapies for the prevention of pre-term labor and the associated neonatal morbidity and mortality.
Michael C. Byrns
doaj   +1 more source

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