Results 91 to 100 of about 43,549 (203)

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Molecular Basis for Rab Prenylation [PDF]

The Journal of Cell Biology, 2000
Rab escort proteins (REP) 1 and 2 are closely related mammalian proteins required for prenylation of newly synthesized Rab GTPases by the cytosolic heterodimeric Rab geranylgeranyl transferase II complex (RabGG transferase). REP1 in mammalian cells is the product of the choroideremia gene (CHM).
C, Alory, W E, Balch
openaire   +2 more sources

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Heart matters: How glucose‐ and lipid‐modulating drugs remodel epicardial adipose tissue accumulation, inflammatory patterns and browning

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 878-894, February 2026.
Abstract Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot located between the myocardium and the visceral pericardium, exerting direct paracrine and vasocrine effects on the heart and coronary vessels. Under physiological conditions, EAT supports myocardial energy metabolism and thermoregulation through fatty acid supply and
Elisabeth Heuboeck, Charnkamal Singh Bhogal, Markus Mandl   +2 more
wiley   +1 more source

Lawsonia intracellularis T3SS effector LI0758, an Rce1 ortholog, activates MAPK and NF-κB signaling in mammalian cells

Veterinary Research
Lawsonia intracellularis, a Gram-negative obligate intracellular bacterium causing porcine proliferative enteropathy, possesses a type III secretion system (T3SS), yet only a handful of its substrates have been experimentally characterized. In this study,
Yuanxiu Zhong, Yiyun Duan, Fenju Lai, Jinhua Zhang, Yimin Dai   +4 more
doaj   +1 more source

7-Isopentenyloxycoumarin: What Is New across the Last Decade

Molecules, 2020
7-Isopentenyloxycoumarin is among the most widespread naturally occurring prenyloxy umbelliferone derivatives. This secondary metabolite of mixed biosynthetic origin has been typically isolated from plants belonging to several genera of the Rutaceae and ...
Francesca Preziuso, Salvatore Genovese, Lorenzo Marchetti, Majid Sharifi-Rad, Lucia Palumbo, Francesco Epifano, Serena Fiorito   +6 more
doaj   +1 more source

GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis [PDF]

, 2014
Background: Hepatocellular carcinoma (HCC) has been associated with diabetes and obesity, but a possible connection with the metabolic syndrome (MetS) and its potential interaction with hepatitis and cirrhosis are open to discussion.
Chen, Jun, Ding, Yi-tao, Li, Chao-jun, Liu, Jia, Shao, Jiao-jiao, Shen, Xiao, Xia, Hong-guang, Xue, Bin, Yu, De-cai   +8 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, Volume 600, Issue 2, Page 251-266, January 2026.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Investigation of LKB1 Ser⁴³¹ phosphorylation and Cys⁴³³ farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity [PDF]

, 2014
The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK (AMP-activated protein kinase) and 12 members of the AMPK-related family of protein kinases. The highly conserved C-terminal residues of LKB1 are phosphorylated (Ser(431)
Alessi, Alessi, Alessi, Andrade-Vieira, Baas, Barnes, Bayascas, Boudeau, Boudeau, Boutin, Carling, Carling, Chen, Clark, Collins, Corton, Dario R. Alessi, Davisson, Denison, Denison, Farnsworth, Fogarty, Fogarty, Foretz, Gwinn, Hardie, Hardie, Hawley, Hayashi, Hemminki, Henriksson, Hunter, Jansen, Jeppesen, Ji, Joby Varghese, Kei Sakamoto, Kishi, Koh, Komander, Liu, Lizcano, Maria Stella Ritorto, Martin, McLaughlin, Mitchelhill, Moores, Mora, Najafov, Nakada, Natalia Shpiro, Oakhill, Paul Davies, Robert Gourlay, Sakamoto, Sakamoto, Sakamoto, Sanchez-Cespedes, Sanchez-Cespedes, Sanders, Sapkota, Sapkota, Screaton, Shaw, Shelly, Su, Towler, Vanessa P. Houde, Vavvas, Viollet, Wiggin, Woods, Wullschleger, Zagorska, Zeqiraj, Zeqiraj, Zhang   +76 more
core   +2 more sources

Melanoma: Pathogenesis and Targeted Therapy

MedComm, Volume 7, Issue 1, January 2026.
The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Yu Jiang   +5 more
wiley   +1 more source