Results 101 to 110 of about 43,549 (203)

La prénylation des protéines chez les insectes : cible prometteuse pour le développement d'insecticides biorationnels ciblant les Lépidoptères ?

Biotechnologie, Agronomie, Société et Environnement, 2014
Protein prenylation in insects: a potential target for the development of bio-rational insecticides targeting the Lepidoptera?. Short-chain prenyltransferases (farnesyl diphosphate synthase [FPPS] and geranylgeranyl diphosphate synthase [GGPPS]) and ...
Barbar, A., Cusson, M.
doaj  

G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma [PDF]

, 1992
Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) consist of a nucleotide-binding alpha subunit and a high- affinity complex of beta and gamma subunits.
Gilman, Alfred G., Iñiguez-Lluhi, Jorge A., Robishaw, Janet D., Simon, Melvin I.   +3 more
core  

Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells [PDF]

, 2006
BACKGROUND: Nitrogen-containing bisphosphonates (N-BPs) have been designed to inhibit osteoclast-mediated bone resorption. However, it is now accepted that part of their anti-tumor activities is related to interference with the mevalonate pathway ...
M Goffinet, M Thoulouzan, A Pradines, I Lajoie-Mazenc, Carolyn Weinbaum, JC Faye, S Séronie-Vivien, MJ Rogers, JR Green, D Amin, JD Bergstrom, K Thompson, E van Beek, HL Benford, SP Luckman, T Iguchi, JE Fisher, K Sawada, C Denoyelle, FP Coxon, ER Van Beek, GM Oades, SG Senaratne, SS Virtanen, F Saad, MR Smith, S Boissier, MV Lee, EC Lerner, TF McGuire, O Cussenot, P Skehan, AB Awad, E Corey, DC Crick, RB Lobell, SA Holstein, SE Ownby, C Allal, JE Dunford, JE Fisher   +40 more
core   +2 more sources

Atorvastatin Impairs Pathways Associated With Skeletal Muscle Function and Health in Myoblasts From Older Adults

JCSM Communications, Volume 9, Issue 1, January/June 2026.
ABSTRACT Background Statins are widely prescribed to reduce low‐density lipoprotein (LDL) cholesterol to decrease the risk of cardiovascular disease. However, there are ongoing concerns surrounding the frequently reported skeletal muscle side effects. These include muscle pain, weakness and reduced function and are defined as statin‐associated muscle ...
Maisha Chaudhery, Mark A. Burton, Hanan Y. Sharkh, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop, Emma S. Garratt   +10 more
wiley   +1 more source

The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization [PDF]

, 1994
C-terminal lipid modifications are essential for the interaction of Ras-related proteins with membranes. While all Ras proteins are farnesylated and some palmitoylated, the majority of other Ras-related proteins are geranylgeranylated.
Beranger, F., Paterson, H., Powers, S., de Gunzburg, J., Hancock, J. F.   +4 more
core   +1 more source

Is a gene-centric human proteome project the best way for proteomics to serve biology? [PDF]

, 2010
With the recent developments in proteomic technologies, a complete human proteome project (HPP) appears feasible for the first time. However, there is still debate as to how it should be designed and what it should encompass.
A gene-centric Human Proteome project, Addona, Aicher, Andersen, Anderson, Anderson, Anderson, Baker, Berglund, Burckstummer, Butkinaree, Charrier, Cheng, Christensen, Deutsch, Foster, Fusaro, Gavin, Golub, Graumann, Hochstrasser, Ivanov, John, Kuhn, Lange, Lasonder, Lescuyer, Lu, Mallick, Maltese, Mathivanan, Pearson, Picotti, Picotti, Rigaut, Rout, Sato, Seo, Service, Taylor, Trinkle-Mulcahy, Unwin, Venter, Wang, Washburn, Weinberg, Whiteaker, Willumsen, Yang   +48 more
core   +5 more sources

Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2

Molecules, 2016
Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2.
Liyan Wang, Yanhua Wu, Yongtao Chen, Jiaxin Zou, Xiaofan Li   +4 more
doaj   +1 more source

Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis [PDF]

, 2014
An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning ...
Aldegunde M. J., Aldegunde M. J., Aldegunde M. J., Aurélien Letort, Bourgeois D., Bourgeois D., Bourgeois D., Bourgeois D., Bourgeois D., Chatterjee A. K., Cong Ma, De-Liang Long, Doi T., Garber S. B., Goldring P. D., Grieco P. A., Holton R. A., Holton R. A., Joëlle Prunet, Kim S.-H., Ma C., Masters J. J., Mendoza A., Morihara K., Mukaiyama T., Muller B., Muller B., Nicolaou K. C., Rémi Aouzal, Schiltz S., Scholl M., Schwab P., Swindell C. S., Wender P. A., Wender P. A., Wilde N. C., Winkler J. D., Yamazaki Y., Yared J. A., Yvon D.   +39 more
core   +3 more sources

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro[S]

Journal of Lipid Research, 2011
Statins and nitrogenous bisphosphonates (NBP) inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR) and farnesyl diphosphate synthase (FDPS), respectively, leading to depletion of farnesyl diphosphate (FPP) and disruption of protein prenylation.
Brian M. Wasko, Jacqueline P. Smits, Larry W. Shull, David F. Wiemer, Raymond J. Hohl   +4 more
doaj   +1 more source

Fats and function:protein lipid modifications in plant cell signalling [PDF]

, 2017
The post-translational lipid modifications N-myristoylation, prenylation and S-acylation are traditionally associated with increasing protein membrane affinity.
Adjobo-Hermans, Alassimone, Assmann, Batistic, Batistic, Bischoff, Boisson, Bücherl, Couto, de Vries, Dionne Turnbull, Goldberg, Grison, Hemsley, Hemsley, Hemsley, Heo, Kapos, Koh, Konrad, Kumar, Kummel, Lai, Lavy, Li, Liu, Malinsky, Matsui, Meng, Morozova, Nimchuk, Noland, Pierre, Piers A Hemsley, Qi, Qi, Qi, Ranf, Renna, Resh, Running, Running, Ryan, Schiefelbein, Sorek, Sorek, Sorek, Srivastava, Stangl, Takahashi, Thole, Traverso, Zeng, Zhang, Zhou   +54 more
core   +2 more sources