Results 21 to 30 of about 43,549 (203)
Cells, 2020 Nuclear shape modulates cell behavior and function, while aberrant nuclear morphologies correlate with pathological phenotype severity. Nevertheless, functions of specific nuclear morphological features and underlying molecular mechanisms remain poorly ...
Sebastian Martewicz +9 more
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Regulation of protein prenylation
Biomedicine & Pharmacotherapy, 2023 Prenyltransferases (PTases) are known to play a role in embryonic development, normal tissue homeostasis and cancer by posttranslationally modifying proteins involved in these processes. They are being discussed as potential drug targets in an increasing number of diseases, ranging from Alzheimer's disease to malaria.
Dominik Jung, Hagen S. Bachmann
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Biosynthesis of α-Tocopherol and Plastoquinone-9 in spinach chloroplasts [PDF]
, 1980 Prenylation and methylation reaction in al biosynthesis is localized in the envelope membranes of the chloroplasts, while PQ-9 biosynthesis takes place in the envelope membranes and also in the thylakoid membranes.
Mazliak, P. +2 more
core +1 more source
Frontiers in Cellular and Infection Microbiology, 2010 The Dot/Icm type IV translocated Ankyrin B (AnkB) effector of Legionella pneumophila is modified by the host prenylation machinery that anchors it into the outer leaflet of the Legionella-containing vacuole (LCV), which is essential for biological ...
Christopher T Price +3 more
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A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors
Applied Microbiology and Biotechnology, 2023 Abstract The fungal prenyltransferase ShPT from Stereum hirsutum was believed to prenylate 4-hydroxybenzyl alcohol and thereby be involved in the vibralactone biosynthesis. In this study, we demonstrate that hydroxynaphthalenes instead of benzyl alcohol or aldehyde were accepted by ShPT for regular C-prenylation in the ...
Andreas Martin +3 more
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Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents? [PDF]
, 2006 It has been postulated that endothelial cell injury is the initiating event in the pathogenesis of systemic sclerosis, causing attraction, attachment, migration and infiltration of activated T-cells and subsequent production of cytokines and growth ...
Derk, Chris T., Jimenez, Sergio A.
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Molecules, 2022 Herein, we report the use of the Suzuki–Miyaura cross-coupling reaction for the preparation of a library of synthetic derivatives of flavonoids for biological activity assays.
Martina Hurtová +5 more
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A Unique Tryptophan C‐Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway [PDF]
, 2016 Acknowledgements This work was supported by funding of the Academy of Finland (259505), Helsinki University Research grant (490085) and ESCMID grant (4720572) to D.P.F., University of Pittsburgh Central Research Development Fund to X.L., Technology ...
Arnison +21 more
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Multiple domain insertions and losses in the evolution of the Rab prenylation complex
BMC Evolutionary Biology, 2007 Background Rab proteins are regulators of vesicular trafficking, requiring a lipid modification for proper function, prenylation of C-terminal cysteines.
Pereira-Leal Jose B, Rasteiro Rita
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Site of Prenylation Reaction in Synthesis of Phylloquinone (Vitamin K1) by Spinach Chloroplasts [PDF]
, 1981 In spinach chloroplasts, 1,4-dihydroxy-2-naphthoate is prenylated by phytyldiphosphate and subsequently methylated by S-adenosylmethionine to form phylloquinol.
Baldwin +22 more
core +1 more source