Results 51 to 60 of about 43,549 (203)

Photoredox-catalyzed diastereoselective dearomative prenylation and reverse-prenylation of electron-deficient indole derivatives

Nature Communications, 2023
Prenylated and reverse-prenylated indolines are privileged scaffolds in numerous naturally occurring indole alkaloids with a broad spectrum of important biological properties.
Xuexue Chang, Fangqing Zhang, Shibo Zhu, Zhuang Yang, Xiaoming Feng, Yangbin Liu   +5 more
doaj   +1 more source

Prenylated Rab Acceptor Protein Is a Receptor for Prenylated Small GTPases [PDF]

Journal of Biological Chemistry, 2001
Localization of Ras and Ras-like proteins to the correct subcellular compartment is essential for these proteins to mediate their biological effects. Many members of the Ras superfamily (Ha-Ras, N-Ras, TC21, and RhoA) are prenylated in the cytoplasm and then transit through the endomembrane system on their way to the plasma membrane.
C, Figueroa, J, Taylor, A B, Vojtek
openaire   +2 more sources

Prenylation inhibitors stimulate both estrogen receptor α transcriptional activity through AF-1 and AF-2 and estrogen receptor β transcriptional activity [PDF]

, 2005
INTRODUCTION: We showed in a previous study that prenylated proteins play a role in estradiol stimulation of proliferation. However, these proteins antagonize the ability of estrogen receptor (ER) alpha to stimulate estrogen response element (ERE ...
Z Weihua, P Webb, SM Cowley, S Ogawa, K Pettersson, R Reiter, Y Shang, CK Osborne, G Castoria, EK Lobenhofer, CW Wong, M Razandi, F Barletta, A Migliaccio, A Migliaccio, FL Zhang, SF Doisneau-Sixou, D Robyr, P Balaguer, V Kumar, ST Dillon, D Gagne, SF Doisneau-Sixou, LF Su, LF Su, MP Gaub, Y Umayahara, K Paech, MM Liu, J Adnane, CS Hill, PF Lebowitz, C Allal, G Fritz, M Razandi, PA Michaely, M Yamaga, C Giamarchi, P Maruvada, Z Nawaz, ME Engel, M Wherlock, P De Cremoux, W Du, D Rubino, A Avots, AS Alberts, SRD Johnston, SR Johnston, SM Sebti   +49 more
core   +1 more source

Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall, Henry G. Box, Karl A. P. Payne, Stephen A. Marshall, David Leys   +4 more
wiley   +1 more source

Calcitox-aging counterbalanced by endogenous farnesol-like sesquiterpenoids: An undervalued evolutionarily ancient key signaling pathway

Communicative & Integrative Biology, 2017
Cells are powerful miniature electrophoresis chambers, at least during part of their life cycle. They die at the moment the voltage gradient over their plasma membrane, and their ability to drive a self-generated electric current carried by inorganic ...
Arnold De Loof
doaj   +1 more source

Group IVC cytosolic phospholipase A2γ is farnesylated and palmitoylated in mammalian cells

Journal of Lipid Research, 2005
Cytosolic phospholipase A2γ (cPLA2γ) is a member of the group IV family of intracellular phospholipase A2 enzymes, but unlike the well-studied cPLA2α, it is constitutively bound to membrane and is calcium independent.
Dawn E. Tucker, Allison Stewart, Laxman Nallan, Pravine Bendale, Farideh Ghomashchi, Michael H. Gelb, Christina C. Leslie   +6 more
doaj   +1 more source

Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53

Frontiers in Oncology, 2020
Missense mutations in the TP53 gene are among the most frequent alterations in human cancer. Consequently, many tumors show high expression of p53 point mutants, which may acquire novel activities that contribute to develop aggressive tumors.
Carla M Borini Etichetti, Evelyn Arel Zalazar, Nabila Cocordano, Javier Girardini   +3 more
doaj   +1 more source

Biphasic effects of statins on neuron cell functions under oxygen–glucose deprivation and normal culturing conditions via different mechanisms

Pharmacology Research & Perspectives, 2022
While there is a growing interest in the use of statins, HMG‐CoA reductase inhibitors, to treat neurodegenerative diseases, statins are associated with conflicting effects within the central nervous system (CNS) without clear evidence of the underlying ...
Hui Wang, Yun Chen, Ping Li, Yan Chen, Danfang Yu, Qian Tan, Xiaoli Liu, Zhenli Guo   +7 more
doaj   +1 more source

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

eLife, 2021
Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to ...
Marcia A Munoz, Emma K Fletcher, Oliver P Skinner, Julie Jurczyluk, Esther Kristianto, Mark P Hodson, Shuting Sun, Frank H Ebetino, David R Croucher, Philip M Hansbro, Jacqueline R Center, Michael J Rogers   +11 more
doaj   +1 more source

Statins and protein prenylation in cancer cell biology and therapy [PDF]

, 2012
El pdf del artículo es la versión post-print.The use of statins has scaled up to become one of the most prescribed medicines in the world and have been very useful in the manegement of cardiovascular diseases and related mortality.
Fernández-Checa, José C., García-Ruiz, Carmen, Morales, Albert   +2 more
core   +2 more sources