Results 71 to 80 of about 43,549 (203)

Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release [PDF]

, 2010
The SNARE-binding protein complexin (Cpx) has been demonstrated to regulate synaptic vesicle fusion. Previous studies are consistent with Cpx functioning either as a synaptic vesicle fusion clamp to prevent premature exocytosis, or as a facilitator to ...
Cho, Richard W., Littleton, J. Troy, Song, Yun   +2 more
core   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Targeting Protein Prenylation in Progeria [PDF]

Science Translational Medicine, 2013
Results of a recent clinical trial in children with Hutchinson-Gilford progeria spur scientists to consider new therapeutic strategies.
Stephen G, Young, Shao H, Yang, Brandon S J, Davies, Hea-Jin, Jung, Loren G, Fong   +4 more
openaire   +2 more sources

Palladium-Catalyzed Completely Linear-Selective Negishi Cross-Coupling of Allylzinc Halides with Aryl and Vinyl Electrophiles [PDF]

, 2013
Completely linear: The title reaction provides an effective means to access a wide range of prenylated arenes and “skipped dienes” in a completely linear-selective fashion, as demonstrated by a concise synthesis of the anti-HIV natural product siamenol ...
Baba, Balibar, Botta, Botta, Bruno, Denmark, Echavarren, Farina, Farmer, Han, Hatanaka, Hatanaka, Hatanaka, Hoffmann, Joule, Kong, Krahl, Krasovskiy, Kuttruff, Leurs, Li, Lindel, Macklin, McCann, Meragelman, Milne, Mitamura, Nakamura, Obora, Ren, Tello, Trost, Wang, Williams, Xu, Yang, Yang   +36 more
core   +1 more source

Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders

Neuroprotection, Volume 4, Issue 1, Page 30-47, March 2026.
The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan, Roshan S. Raghavan, Dawn Li Wei Koh, Wing Yeng Tan, Igor Iezhitsa, Renu Agarwal   +5 more
wiley   +1 more source

Antitumor Activity of Some Prenylated Xanthones

Pharmaceuticals, 2009
Pyranoxanthones 6-8 were obtained by dehydrogenation of the respective dihydropyranoxanthones 3-5 with DDQ in dry dioxane. Two prenylated xanthones 10,11 were obtained from the reaction of 1-hydroxyxanthone (9) with prenyl bromide in alkaline medium, or ...
Raquel A.P. Castanheiro, Artur M.S. Silva, Naïr A.N. Campos, Maria S.J. Nascimento, Madalena M.M. Pinto   +4 more
doaj   +1 more source

Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Rab geranylgeranyltransferase (GGTase-II, RGGT) catalyses the post-translational modification of eukaryotic Rab GTPases, proteins implicated in several pathologies, including cancer, diabetes, neurodegenerative, and infectious diseases.
Joanna Małolepsza, Aleksandra Marchwicka, Remigiusz A. Serwa, Sanna P. Niinivehmas, Olli T. Pentikäinen, Edyta Gendaszewska-Darmach, Katarzyna M. Błażewska   +6 more
doaj   +1 more source

Biological evaluations of novel 2,3,3-Trisphosphonate in osteoclastic and osteoblastic activities [PDF]

, 2017
Bisphosphonates (BPs) are the first line treatment for many bone diseases including hypercalcimia associated with bone malignancies. In this paper, we introduce a new analogue of bisphosphonate called the 2,3,3-Trisphosphonate (2,3,3-TriPP) that was ...
Boccaccini, Aldo R., Cheong, Yuen Ki, Detsch, Rainer, Huang, Mei, Ren, Guogang   +4 more
core   +3 more sources

Heterologous plastoquinone production using a newly identified O2‐dependent cyanobacterial hydroxylase

The FEBS Journal, Volume 293, Issue 6, Page 1708-1726, March 2026.
In this study, we confirm that PlqH is the hydroxylase operating in plastoquinone biosynthesis in photosynthetic cyanobacteria (Cyanobacteriia). Our phylogenetic analyses demonstrate that cyanobacterial PlqH homologues originated from hydroxylases involved in ubiquinone biosynthesis in bacteria. Plastoquinone production in Escherichia coli was achieved
Morgane Roger‐Margueritat, Margot Beltran, Juliette Schnoebelen, Laura Flandrin, Wafa Rezali, Eline Michel, Sophie S. Abby, Fabien Pierrel   +7 more
wiley   +1 more source

Inclusion of PF68 Surfactant Improves Stability of rAAV Titer when Passed through a Surgical Device Used in Retinal Gene Therapy

Molecular Therapy: Methods & Clinical Development, 2020
Recent advances in recombinant adeno-associated virus (rAAV) gene therapy for choroideremia show gene replacement to be a promising approach. It is, however, well known that contact of vector solution with plastic materials in the surgical device may ...
Maria I. Patrício, Christopher I. Cox, Clare Blue, Alun R. Barnard, Cristina Martinez-Fernandez de la Camara, Robert E. MacLaren   +5 more
doaj   +1 more source