A Comprehensive Analysis of Choroideremia: From Genetic Characterization to Clinical Practice. [PDF]
, 2016 Choroideremia (CHM) is a rare X-linked disease leading to progressive retinal degeneration resulting in blindness. The disorder is caused by mutations in the CHM gene encoding REP-1 protein, an essential component of the Rab geranylgeranyltransferase ...
Avila-Fernandez, A. +20 more
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Artificial lipidation of proteins and peptides: from mechanism to clinical applications
The FEBS Journal, Volume 293, Issue 5, Page 1269-1284, March 2026.Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley +1 more source
Defective Protein Prenylation in a Spectrum of Patients With Mevalonate Kinase Deficiency
Frontiers in Immunology, 2019 The rare autoinflammatory disease mevalonate kinase deficiency (MKD, which includes HIDS and mevalonic aciduria) is caused by recessive, pathogenic variants in the MVK gene encoding mevalonate kinase.
Marcia A. Munoz +10 more
doaj +1 more source
KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models [PDF]
, 2017 BACKGROUND: In non-small cell lung cancer (NSCLC) KRAS-mutant status is a negative prognostic and predictive factor. Nitrogen-containing bisphosphonates inhibit prenylation of small G-proteins (e.g.
Barone +44 more
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Protein prenylation in spinach chloroplasts [PDF]
Proceedings of the National Academy of Sciences, 1999 Protein prenylation in plants was studied by in vivo metabolic 3 H-mevalonate labeling in combination with a range of protein synthesis inhibitors. In spinach cotyledons, this posttranslational protein modification was found to be divided into two categories, one representing the conventional
I, Parmryd, B, Andersson, G, Dallner
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Isoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum [PDF]
, 2013 The antimalarial agent fosmidomycin is a validated inhibitor of the nonmevalonate isoprenoid biosynthesis (methylerythritol 4-phosphate [MEP]) pathway in the malaria parasite, Plasmodium falciparum.
Hodge, Dana +4 more
core +2 more sources
Creation of bioactive non‐natural flavonoids via combinatorial prenylation–glycosylation cascades
mLife, EarlyView.
Hongjiao Zhang +3 more
wiley +1 more source
eJHaem, Volume 7, Issue 1, February 2026.ABSTRACT Background Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM) and a primary cause of disability in affected patients. Its pathogenesis is driven by an imbalance in bone remodeling, largely attributed to the overexpression of C‐C motif chemokine ligand 3 (CCL3). While both bortezomib and statins have been reported
Fujun Qu +6 more
wiley +1 more source
Prenylates Xanthones from Garcinia xanthochymus.
ChemInform, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Wisinee, Chanmahasathien +6 more
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Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells [PDF]
, 2017 Only 40% of patients with advanced ovarian cancer survive more than 5 years. We have previously shown that pitavastatin induces regression of ovarian cancer xenografts in mice.
Abdullah, MI, Abed, MN, Richardson, A
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