Cellular Profiles of Prodynorphin and Preproenkephalin mRNA-Expressing Neurons in the Anterior Olfactory Tubercle of Mice [PDF]
Frontiers in Neural Circuits, 2022 The olfactory tubercle (OT) is a striatal region that receives olfactory inputs. mRNAs of prodynorphin (Pdyn) and preproenkephalin (Penk), precursors of dynorphins and enkephalins, respectively, are strongly expressed in the striatum. Both produce opioid
Ayako Maegawa +9 more
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The Involvement of Endogenous Enkephalins in Glucose Homeostasis [PDF]
Biomedicines, 2023 Obesity has nearly tripled since 1975 and is predicted to continue to escalate. The surge in obesity is expected to increase the risk of diabetes type 2, hypertension, coronary artery disease, and stroke.
Vanessa Escolero +4 more
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Anxiety- and depressive-like responses and c-
Journal of Biomedical Science, 2010 The present study used the preproenkephalin knockout (ppENK) mice to test whether the endogenous enkephalins deficit could facilitate the anxiety- and depressive-like symptoms of posttraumatic stress disorder (PTSD).
Shyu Bai-Chuang +4 more
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Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice [PDF]
Molecular Pain, 2008 Background Mice lacking the preproenkephalin (ppENK) gene are hyperalgesic and show more anxiety and aggression than wild-type (WT) mice. The marked behavioral changes in ppENK knock-out (KO) mice appeared to occur in supraspinal response to painful ...
Sun Wei-Zen +3 more
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Frontiers in Genetics, 2022 Short tandem repeats (STRs) and variable number of tandem repeats (VNTRs) that have been identified at approximately 0.7 and 0.5 million loci in the human genome, respectively, are highly multi-allelic variations rather than single-nucleotide ...
Shinya Kasai +7 more
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Acetaminophen improves tardive akathisia induced by dopamine D2 receptor antagonists
Journal of Pharmacological Sciences, 2023 Tardive akathisia is a movement disorder characterized by internal restlessness with an uncontrollable urge to move, leading to repetitive movements. It is a common side effect of long-term treatment with dopamine D2 receptor antagonists.
Koki Nagaoka +3 more
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Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons. [PDF]
PLoS ONE, 2009 The widespread distribution of the tumor suppressor PTEN in the nervous system suggests a role in a broad range of brain functions. PTEN negatively regulates the signaling pathways initiated by protein kinase B (Akt) thereby regulating signals for growth,
Oscar Diaz-Ruiz +7 more
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Maternally administered sustained-release naltrexone in rats affects offspring neurochemistry and behaviour in adulthood. [PDF]
PLoS ONE, 2012 Naltrexone is not recommended during pregnancy. However, sustained-release naltrexone implant use in humans has resulted in cases of inadvertent foetal exposure.
Waleed O Farid +5 more
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Differential Changes in Striatal Projection Neurons in R6/2 Transgenic Mice for Huntington's Disease
Neurobiology of Disease, 2002 In early adult-onset Huntington's disease (HD), enkephalinergic striatopallidal projection neurons show preferential loss, reduced preproenkephalin (PPE) expression in surviving striatopallidal neurons, and loss of fibers in their projection target area.
Z. Sun +4 more
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Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis [PDF]
, 2007 The initiation of mammalian puberty and the maintenance of female reproductive cycles are events controlled by hypothalamic neurons that secrete the decapeptide gonadotropin-releasing hormone (GnRH).
Sabine Heger +56 more
core +1 more source