Results 21 to 30 of about 3,085 (184)

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

The structure and expression of the preproenkephalin gene [PDF]

Nucleic Acids Research, 1982
Enkephalins are pentapeptides with opioid activity which are found in a wide variety of tissues. Studies of enkephalin-containing peptides from the adrenal gland have established that the mature pentapeptides are derived by proteolytic processing of a precursor protein.
Legon, Steve, Glover, David M., Hughes, John, Lowry, Philip J., Rigby, Peter W. J., Watson, Christine J.   +5 more
openaire   +3 more sources

Current Insights on Bioactive Molecules, Antioxidant, Anti‐Inflammatory, and Other Pharmacological Activities of Cinnamomum camphora Linn

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
C. camphora is a renowned traditional Unani medicinal herb and belongs to the family Lauraceae. It has therapeutic applications in various ailments and prophylactic properties to prevent flu‐like epidemic symptoms and COVID‐19. This comprehensive appraisal is to familiarize the reader with the traditional, broad applications of camphor both in Unani ...
Mohamed Joonus Aynul Fazmiya, Arshiya Sultana, Khaleequr Rahman, Md Belal Bin Heyat, Sumbul, Faijan Akhtar, Salabat Khan, Seth Christopher Yaw Appiah, Tarique Hussain   +8 more
wiley   +1 more source

Morphine alters preproenkephalin gene expression

Brain Research, 1988
Rats made tolerant/dependent to morphine by s.c. implantation of drug pellets displayed a significant decrease in striatal preproenkephalin mRNA that persisted during the period of withdrawal. Levels of Met-enkephalin were normal at the end of treatment, but reduced after withdrawal.
G R, Uhl, J P, Ryan, J P, Schwartz
openaire   +2 more sources

Neprilysin inhibition does not alter dynamic of proenkephalin‐A 119‐159 and pro‐substance P in heart failure

ESC Heart Failure, Volume 8, Issue 3, Page 2016-2024, June 2021., 2021
Abstract Aims As NEP degrades many substrates, the specific therapeutic mechanism of NEP inhibition with angiotensin receptor neprilysin inhibitor (ARNi) in heart failure with reduced ejection fraction (HFrEF) is not entirely evident. The aim of this study was to investigate the response of two substrates of NEP—the tachykinin and enkephalin systems—to
Henrike Arfsten, Georg Goliasch, Philipp E. Bartko, Suriya Prausmüller, Georg Spinka, Anna Cho, Johannes Novak, Julia Mascherbauer, Helmuth Haslacher, Guido Strunk, Martin Hülsmann, Noemi Pavo   +11 more
wiley   +1 more source

Disease-Modifying Trials in Treated Parkinson's Disease: "Stable Treated" Does Not Equate with Biological Stability. [PDF]

Mov Disord
Abstract Traditionally, clinical trials of putative disease‐modifying therapies in Parkinson's disease have enrolled untreated patients at the earliest clinical stages of their disease. Due to a number of challenges inherent with this approach, there has been a recent move to a different study design, enrolling patients who are already taking “stable ...
Mouradian MM, Stoessl AJ, Lang AE.
europepmc   +2 more sources

Progression of basal ganglia pathology in heterozygous Q175 knock‐in Huntington's disease mice

Journal of Comparative Neurology, Volume 529, Issue 7, Page 1327-1371, May 1, 2021., 2021
Striatal cholinergic (ChAT+) interneurons in WT and heterozygous Q175 mice at 18 months of age. The images show that striatal cholinergic interneuron abundance is comparable, but dendrites in Q175 mice are significantly fewer and shorter. These abnormalities and diverse striatal projection neuron abnormalities develop between 2 and 6 months of age in ...
Yunping Deng, Hongbing Wang, Marion Joni, Radhika Sekhri, Anton Reiner   +4 more
wiley   +1 more source

Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist–induced orofacial dyskinesia

JCI Insight, 2021
Antipsychotics often cause tardive dyskinesia, an adverse symptom of involuntary hyperkinetic movements. Analysis of the US Food and Drug Administration Adverse Event Reporting System and JMDC insurance claims revealed that acetaminophen prevented the ...
Koki Nagaoka, Takuya Nagashima, Nozomi Asaoka, Hiroki Yamamoto, Chihiro Toda, Gen Kayanuma, Soni Siswanto, Yasuhiro Funahashi, Keisuke Kuroda, Kozo Kaibuchi, Yasuo Mori, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko   +13 more
doaj   +1 more source

Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model

Molecular Pain, 2008
Background A chronic pancreatitis model was developed in young male Lewis rats fed a high-fat and alcohol liquid diet beginning at three weeks. The model was used to assess time course and efficacy of a replication defective herpes simplex virus type 1 ...
Ren Yong, Lu Ying, Chu Rong, McNearney Terry A, Yang Hong, Yeomans David C, Wilson Steven P, Westlund Karin N   +7 more
doaj   +1 more source

Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes

Neurobiology of Disease, 2008
Coadministration of entacapone with levodopa attenuates motor complications in experimental models of Parkinson's disease. The mechanisms underlying entacapone effects are unknown. We investigated the effect of entacapone, on: long-duration response (LDR)
C. Marin, E. Aguilar, G. Mengod, R. Cortés, M.C. Rodríguez-Oroz, J.A. Obeso   +5 more
doaj   +1 more source