Neurobiology of Disease, 2001 GABA and enkephalin-utilizing efferents from the striatum to the external segment of the pallidal complex (GPe) are thought to be overactive in Parkinson's disease (PD).
Erwan Bezard +4 more
doaj +1 more source
Reward associated with singing behavior correlates with opioid-related gene expression in the medial preoptic nucleus in male European starlings. [PDF]
PLoS ONE, 2014 Birdsong consists of species-specific learned vocal sequences that are used primarily to attract mates and to repel competitors during the breeding season.
Lauren V Riters +3 more
doaj +1 more source
Ovariectomy Alters Gene Expression of the Hippocampal Formation in Middle-Aged Rats [PDF]
, 2016 Ovarian hormones regulate the transcriptome of the hippocampus and modulate its functions. During 29 menopause, this complex signaling declines, leading to impaired learning and memory.
Hrabovszky, Erik +4 more
core +1 more source
Preprotachykinin A (PPTA) is expressed by a distinct population of excitatory neurons in the mouse superficial spinal dorsal horn including cells that respond to noxious and pruritic stimuli [PDF]
, 2017 The superficial dorsal horn, which is the main target for nociceptive and pruritoceptive primary afferents, contains a high density of excitatory interneurons.
Bell, Andrew M. +8 more
core +1 more source
Cerebrospinal fluid levels of opioid peptides in fibromyalgia and chronic low back pain [PDF]
, 2004 Background The mechanism(s) of nociceptive dysfunction and potential roles of opioid neurotransmitters are unresolved in the chronic pain syndromes of fibromyalgia and chronic low back pain.
James N Baraniuk +24 more
core +2 more sources
Frontiers in Neural Circuits, 2013 The striatum projection neurons are striatonigral and striatopallidal medium sized-spiny neurons (MSNs) that preferentially express D1 (D1R) and D2 (D2R) dopamine receptors, respectively.
Giuseppe eGangarossa +22 more
doaj +1 more source
Improved Long-term Expression from Helper Virus-free HSV-1 Vectors Packaged Using Combinations of Mutated HSV-1 Proteins that Include the UL13 Protein Kinase and Specific Components of the VP16 Transcriptional Complex [PDF]
, 2011 Background: Herpes Simplex Virus (HSV-1) gene expression is thought to shut off recombinant gene expression from HSV-1 vectors; however, in a helper virus-free HSV-1 vector system, a number of promoters support only short-term expression.
Geller, Alfred I. +2 more
core +1 more source
Cell Transplantation, 2013 Transplantation of allogeneic adrenal chromaffin cells demonstrated the promise of favorable outcomes for pain relief in patients. However, there is a very limited availability of suitable human adrenal gland tissues, genetically well-matched donors in ...
T. Qu M.D., Ph.D. +5 more
doaj +1 more source
Frontiers in Systems Neuroscience, 2011 Exposure to psychostimulants increases brain-derived neurotrophic factor (BDNF) mRNA and protein levels in the cerebral cortex and subcortical structures.
Jacqueline F McGinty +3 more
doaj +1 more source
Incentive learning underlying cocaine relapse requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons [PDF]
, 2010 Understanding the psychobiological basis of relapse remains a challenge in developing therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to environmental stimuli previously associated with drug taking.
Bilbao, Ainhoa +11 more
core +2 more sources