Results 51 to 60 of about 3,085 (184)

Endogenous opioids in the olfactory tubercle and their roles in olfaction and quality of life

Frontiers in Neural Circuits
Olfactory dysfunctions decrease daily quality of life (QOL) in part by reducing the pleasure of eating. Olfaction plays an essential role in flavor sensation and palatability.
Koshi Murata, Koshi Murata, Ayako Maegawa, Ayako Maegawa, Ayako Maegawa, Yoshimasa Imoto, Yoshimasa Imoto, Shigeharu Fujieda, Yugo Fukazawa, Yugo Fukazawa   +9 more
doaj   +1 more source

Acupuncture analgesia for temporal summation of experimental pain: A randomised controlled study [PDF]

, 2010
Background: Temporal summation of pain, a phenomenon of the central nervous system (CNS), represents enhanced painful sensation or reduced pain threshold upon repeated stimulation. This pain model has been used to evaluate the analgesic effect of various
Da Costa, C, Feng, J, Li, C, Lu, D, Xue, C, Zheng, Z   +5 more
core   +1 more source

Resolving pathobiological mechanisms relating to Huntington disease: Gait, balance, and involuntary movements in mice with targeted ablation of striatal D1 dopamine receptor cells

Neurobiology of Disease, 2014
Progressive cell loss is observed in the striatum, cerebral cortex, thalamus, hypothalamus, subthalamic nucleus and hippocampus in Huntington disease. In the striatum, dopamine-responsive medium spiny neurons are preferentially lost.
Hyun Ah. Kim, Luning Jiang, Heather Madsen, Clare L. Parish, Jim Massalas, Arthur Smardencas, Claire O'Leary, Ilse Gantois, Colm O'Tuathaigh, John L. Waddington, Michelle E. Ehrlich, Andrew J. Lawrence, John Drago   +12 more
doaj   +1 more source

Why Does Exercise “Triggerâ€? Adaptive Protective Responses in the Heart? [PDF]

, 2015
Numerous epidemiological studies suggest that individuals who exercise have decreased cardiac morbidity and mortality. Pre-clinical studies in animal models also find clear cardioprotective phenotypes in animals that exercise, specifically characterized ...
A. Garlid, A. Harzand, A. Kavazis, A. Napp, A. Oberman, A. Sukhodub, A. Vegh, A. Webb, Alvin M. Tsang, B. Fredholm, B. Prosser, C. Baines, C. Blais, Jr., C. Debruille, C. Donges, C. Farah, C. Frasier, C. Frasier, C. Frasier, C. Gauthier, C. Ward, D. Bowles, D. Brown, D. Brown, D. Brown, D. Brown, D. Coven, D. Jones, David A. Brown, E. Chouchani, E. Dabkowski, E. Dickson, G. Sanchez, G. Tavernier, H. Demirel, H. Hamalainen, H. Saini, H. Tsutsui, I. Lee, J. Brown, J. Calvert, J. French, J. McCord, J. Quindry, J. Quindry, J. Quindry, J. Sadoshima, J. Springhorn, J. Starnes, J. Wang, J. Weil, J. Zweier, Je-J Schultz, K. Hamilton, K. Hamilton, K. Husain, K. Jacobson, L. Babai, L. Eddy, L. Horwitz, L. Schwarz, Luke M. Stewart, M. Frederich, M. Michel, M. Michelsen, M. Misra, M. Nelson, M. Vidal, M. Zhou, N. Bryan, N. Bryan, N. Kaludercic, N. Musi, N. Yamashita, O. van den Brink, P. Bianchi, P. Chandrasekera, P. Donoso, P. Kakarla, P. Kang, P. Rahkila, P. Ramires, P. Venditti, Q. Zhang, R. Bolli, R. Bolli, R. Domenech, R. Domenech, R. Fryer, R. Kloner, R. Russell, 3rd, R. Taylor, R. Taylor, R. Taylor, Rick J. Alleman, S. Bhushan, S. Hoshida, S. Lennon, S. Maggirwar, S. Mora, S. Powers, S. Steinberg, T. Galvao, T. Pain, T. Sato, V. Barbosa, W. Bloch, W. Sessa, W. Watkinson, X. Liu, Y. Akita, Y. Lee, Y. Ogura   +112 more
core   +1 more source

Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet.

PLoS ONE, 2014
ObjectiveLeptin resistance is a common hallmark of obesity. Rats on a free-choice high-fat high-sugar (fcHFHS) diet are resistant to peripherally administered leptin. The aim of this study was to investigate feeding responses to central leptin as well as
José K van den Heuvel, Leslie Eggels, Eric Fliers, Andries Kalsbeek, Roger A H Adan, Susanne E la Fleur   +5 more
doaj   +1 more source

Alterations in peptide levels in Parkinson's disease and incidental Lewy body disease [PDF]

, 2007
The levels of the neuropeptides Met- and Leu-enkephalin (MET-ENK, LEU-ENK), substance P and neurotensin were measured by a combined high performance liquid chromatography/radioimmunoassay (HPLC/RIA) method in postmortem samples of basal ganglia from ...
Beyer, Cordian, Dang, Jon, Habib, Pardes, Hoffmann, Stefanie, Lammerding, Leoni, Slowik, Alexander, Zendedel, Adib   +6 more
core   +1 more source

Extracellular Vesicles Derived From Mesenchymal Bone Marrow Cells Promote Antinociception in a Murine Model of Diabetic Neuropathy via the Endogenous Opioid System

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
This study investigates the analgesic potential of extracellular vesicles derived from bone marrow mesenchymal stem cells (EV‐BMSC) in diabetic sensory neuropathy. EV‐BMSC reproduce the pain‐relieving effects of BMSC transplantation through opioid‐mediated mechanisms, highlighting a promising cell‐free therapeutic approach for neuropathic pain ...
Gessica S. A. Silva, Afrânio F. Evangelista, Girlaine C. Santos, Thaís A. Santana, Luiza C. F. Opretzka, Pedro S. S. Lauria, Marco A. Stimamiglio, Milena B. P. Soares, Cristiane F. Villarreal   +8 more
wiley   +1 more source

5-HT6R Viral Vector-Mediated Indirect Pathway Activation in the Dorsolateral Striatum: A Discussion on Basal Ganglia Habitual and Goal-Directed Circuits [PDF]

, 2018
Altering maladaptive behavioral tendencies is relevant for clinical interventions, making research on underlying mechanisms of habit essential. Mechanisms of habit are explored here with differential activation of the indirect pathway in the basal ...
Winn, Caleb S
core   +1 more source

β-arrestin regulates estradiol membrane-initiated signaling in hypothalamic neurons. [PDF]

, 2015
Estradiol (E2) action in the nervous system is the result of both direct nuclear and membrane-initiated signaling (EMS). E2 regulates membrane estrogen receptor-α (ERα) levels through opposing mechanisms of EMS-mediated trafficking and internalization ...
Abrams, Matthew C, Micevych, Paul E, Wong, Angela M   +2 more
core   +3 more sources

Genetically Engineered Human Mesenchymal Stem Cells Produce Met-Enkephalin at Augmented Higher Levels in Vitro

Cell Transplantation, 2006
We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain.
Ikuko Sugaya, Tingyu Qu, Kiminobu Sugaya, George D. Pappas   +3 more
doaj   +1 more source