Results 61 to 70 of about 3,085 (184)

A preproenkephalin—Neurofilament chimeric promoter in a helper virus-free herpes simplex virus vector enhances long-term expression in the rat striatum

Neurobiology of Disease, 2004
Helper virus-free herpes simplex virus (HSV-1) plasmid vectors are an attractive system for gene transfer into neurons in the brain, but promoters that support long-term, neuronal-specific expression are required.
Xiaodan Wang, Lingxin Kong, Guo-rong Zhang, Mei Sun, Alfred I Geller   +4 more
doaj   +1 more source

Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary [PDF]

, 1982
A 4,000-dalton dynorphin was isolated from porcine pituitary. It has 32 amino acids (Mr = 3,986), with the previously described heptadecapeptide (now called dynorphin A) at its amino terminus and a related tridecapeptide, dynorphin B, at its carboxyl ...
Fischli, Walter, Goldstein, Avram, Hood, Leroy E., Hunkapiller, Michael W.   +3 more
core  

Peripheral Administration of Morphine Attenuates Postincisional Pain by Regulating Macrophage Polarization through COX-2-Dependent Pathway [PDF]

, 2014
BACKGROUND: Macrophage infiltration to inflammatory sites promotes wound repair and may be involved in pain hypersensitivity after surgical incision. We recently reported that the development of hyperalgesia during chronic inflammation is regulated by ...
Kohei Godai, Maiko Hasegawa-Moriyama, Masayasu Kojima, Tae Kurimoto, Takahiro Sato, Takayuki Saito, Tomotsugu Yamada, Yuichi Kanmura   +7 more
core   +2 more sources

Hypoxia‐inducible factor‐2 stabilization is not sufficient to induce erythropoietin production in deeper medullary fibroblasts

The Journal of Physiology, Volume 603, Issue 19, Page 5777-5804, October 1, 2025.
Abstract figure legend Renal erythropoietin (EPO) production was analysed in anaemic and PHD‐inhibitor‐treated wild‐type mice, and mice with genetic fibroblast‐specific hypoxia‐inducible factor (HIF)‐2 stabilization. We found, that PHD inhibition activated HIF‐2 signalling in interstitial fibroblasts of all kidney zones as observed by the induction of ...
Bettina K. M. Firmke, Michaela A. A. Fuchs, Lena M. Süß, Anna‐Lena Forst, Armin Kurtz, Katharina A.‐E. Broeker   +5 more
wiley   +1 more source

Gene Network Dysregulation in the Trigeminal Ganglia and Nucleus Accumbens of a Model of Chronic Migraine-Associated Hyperalgesia

Frontiers in Systems Neuroscience, 2018
The pharmacological agent nitroglycerin (NTG) elicits hyperalgesia and allodynia in mice. This model has been used to study the neurological disorder of trigeminovascular pain or migraine, a debilitating form of hyperalgesia.
Hyeonsoo Jeong, Laura S. Moye, Bruce R. Southey, Alvaro G. Hernandez, Isaac Dripps, Elena V. Romanova, Stanislav S. Rubakhin, Jonathan V. Sweedler, Amynah A. Pradhan, Sandra L. Rodriguez-Zas, Sandra L. Rodriguez-Zas   +10 more
doaj   +1 more source

Effects of high-fat diet withdrawal on behavior and striatal opioid gene expression [abstract] [PDF]

, 2006
only availableFaculty Mentor: Dr. Matthew Will, Psychological SciencesThe central opioid systems play a critical role in certain aspects of food intake, particularly with regard to the rewarding impact of calorically dense food such as fat and sugar. The
Parker, K. E., Sawani, Ali M.
core  

SERPINB5 and AKAP12-- Expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma [PDF]

, 2010
Background Early metastasis and infiltration are survival limiting characteristics of pancreatic ductal adenocarcinoma (PDAC). Thus, PDAC is likely to harbor alterations in metastasis suppressor genes that may provide novel diagnostic and therapeutic ...
Andreas Enns, Joerg Haier, Kostadin O Petrov, Norbert Senninger, Soeren T Mees, Wolf A Mardin   +5 more
core   +3 more sources

Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene

Journal of Neuroscience Research, Volume 97, Issue 12, Page 1590-1605, December 2019., 2019
Abstract Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock‐in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q140s, mouse exon 1 Htt was replaced with a ...
Nicholas R. Franich, Miriam A. Hickey, Chunni Zhu, Georgina F. Osborne, Nadira Ali, Tiffany Chu, Nicholas H. Bove, Vincent Lemesre, Renata P. Lerner, Scott O. Zeitlin, David Howland, Andreas Neueder, Christian Landles, Gillian P. Bates, Marie‐Francoise Chesselet   +14 more
wiley   +1 more source

Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning

Neurochemistry International, 2019
The ventral pallidum (VP) is a critical component of the basal ganglia neurocircuitry regulating learning and decision making; however, its precise role in controlling associative learning of environmental stimuli conditioned to appetitive or aversive outcomes is still unclear.
Tom, Macpherson, Hiroyuki, Mizoguchi, Akihiro, Yamanaka, Takatoshi, Hikida   +3 more
openaire   +3 more sources

Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus [PDF]

Proceedings of the National Academy of Sciences, 1999
To test the utility of gene therapeutic approaches for the treatment of pain, a recombinant herpes simplex virus, type 1, has been engineered to contain the cDNA for an opioid peptide precursor, human preproenkephalin, under control of the human cytomegalovirus promoter.
S P, Wilson, D C, Yeomans, M A, Bender, Y, Lu, W F, Goins, J C, Glorioso   +5 more
openaire   +2 more sources