Results 191 to 200 of about 25,523 (241)
Some of the next articles are maybe not open access.
Presenilin-interacting proteins
Expert Reviews in Molecular Medicine, 2002Familial Alzheimer's disease (FAD) accounts for 5–10% of deaths from Alzheimer's disease (AD), and approximately 50% of these cases have been definitely linked to missense mutations in three genes, encoding the amyloid precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2). Of these, the vast majority of FAD-linked mutations are within PS1.
Qi, Chen, David, Schubert
openaire +2 more sources
Intramembrane proteolysis by presenilins
Nature Reviews Molecular Cell Biology, 2000Many neurodegenerative diseases involve the deposition of insoluble amyloid molecules. In Alzheimer's disease, for example, the amyloid beta-peptide (A beta) is the main component of the characteristic senile plaques. Proteolytic enzymes called secretases are involved in generating A beta, and one of these may have been identified as presenilin--a ...
H, Steiner, C, Haass
openaire +2 more sources
2007
Abstract Alzheimer‘s disease (AD) is the leading cause of dementia in the elderly. While the vast majority of AD occurs as an age-associated disorder, autosomal dominant inheritance of mutant genes APP, PSENl, or PSEN2, which encode the amyloid precursor protein (APP), presenilin 1 (PSl), or presenilin 2 (PS2), respectively, cause ...
Kulandaivelu S Vetrivel +1 more
openaire +1 more source
Abstract Alzheimer‘s disease (AD) is the leading cause of dementia in the elderly. While the vast majority of AD occurs as an age-associated disorder, autosomal dominant inheritance of mutant genes APP, PSENl, or PSEN2, which encode the amyloid precursor protein (APP), presenilin 1 (PSl), or presenilin 2 (PS2), respectively, cause ...
Kulandaivelu S Vetrivel +1 more
openaire +1 more source
Presenilins and Alzheimer's disease
Current Opinion in Neurobiology, 1997Mutations in the genes encoding the presenilins cause the majority of early-onset cases of Alzheimer's disease (AD). The identification of the presenilin genes has provided new opportunities for elucidating the molecular mechanisms underlying the etiology and pathogenesis of AD.
T W, Kim, R E, Tanzi
openaire +2 more sources
Presenilin-mediated signal transduction
Physiology & Behavior, 2007Presenilin proteins, mutated forms of which cause early onset familial Alzheimer's disease, are capable of modulating various cell signal transduction pathways, the most extensively studied of which has been intracellular calcium signalling. Disease causing presenilin mutations can potentiate inositol(1,4,5)trisphosphate (InsP3) mediated endoplasmic ...
Richard F, Cowburn +4 more
openaire +2 more sources
Presenilin diversifies its portfolio
Trends in Genetics, 2007Presenilin, the catalytic member of the gamma-secretase proteolytic complex, was discovered through its roles in generating Alzheimer's-disease-associated amyloid-beta peptides from the amyloid-beta precursor protein and in releasing the transcriptionally active domain of the receptor Notch.
Annette L, Parks, Daniel, Curtis
openaire +2 more sources
Molecular Neurobiology, 1999
Most of early-onset forms of Alzheimer's disease (AD) are caused by inherited mutations located on chromosomes 14 and 1, the gene products of which have been recently identified and referred to as presenilins 1 (PS1) and 2 (PS2), respectively. The first phenotypic alterations triggered by mutated PS were reported to be an increased production of the ...
openaire +2 more sources
Most of early-onset forms of Alzheimer's disease (AD) are caused by inherited mutations located on chromosomes 14 and 1, the gene products of which have been recently identified and referred to as presenilins 1 (PS1) and 2 (PS2), respectively. The first phenotypic alterations triggered by mutated PS were reported to be an increased production of the ...
openaire +2 more sources
The Neuroscientist, 1999
Presenilin-1 and presenilin-2 are highly homologous genes located on chromosomes 14 and 1, respectively, that have recently been linked to some cases of early-onset autosomal dominant inherited forms of Alzhei mer's disease (AD). Presenilins are integral membrane proteins localized in the endoplasmic reticulum of neurons throughout the nervous system.
Mark P. Mattson, null Qing Guo
openaire +1 more source
Presenilin-1 and presenilin-2 are highly homologous genes located on chromosomes 14 and 1, respectively, that have recently been linked to some cases of early-onset autosomal dominant inherited forms of Alzhei mer's disease (AD). Presenilins are integral membrane proteins localized in the endoplasmic reticulum of neurons throughout the nervous system.
Mark P. Mattson, null Qing Guo
openaire +1 more source