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The Architecture of the Active Zone in the Presynaptic Nerve Terminal
Physiology, 2004Active zones are highly specialized sites for release of neurotransmitter from presynaptic nerve terminals. The architecture of the active zone is exquisitely designed to facilitate the regulated tethering, docking, and fusing of the synaptic vesicles with the plasma membrane.
R Grace, Zhai, Hugo J, Bellen
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UNATTACHED PRESYNAPTIC TERMINALS IN A CEREBELLAR NEUROBLASTOMA IN THE HUMAN
Neuropathology and Applied Neurobiology, 1979Hirano A. & Shin W.‐Y. (1979) Neuropathology and Applied Neurobiology5, 63–70Unattached presynaptic terminals in a cerebellar neuroblastoma in the humanMany unattached presynaptic terminals were seen in a cerebellar neuroblastoma removed from a 3‐year‐old boy.
A, Hirano, W Y, Shin
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Microdomains of High Calcium Concentration in a Presynaptic Terminal
Science, 1992Increases in intracellular calcium concentration are required for the release of neurotransmitter from presynaptic terminals in all neurons. However, the mechanism by which calcium exerts its effect is not known. A low-sensitivity calcium-dependent photoprotein ( n -aequorin-J) was injected into the presynaptic ...
R, Llinás, M, Sugimori, R B, Silver
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Local translation in presynaptic terminals
Science, 2019Cellular Neuroscience Proteins carry out most of the functions in cells, including neurons, which are one of the most morphologically complex cell types in the body. This poses challenges for how proteins can be supplied to remote regions where connections (synapses) are made with other neurons.
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Huntingtin is associated with cytomatrix proteins at the presynaptic terminal
Molecular and Cellular Neuroscience, 2014Huntington's disease (HD) is a single gene disorder produced by expansion of the gene encoding huntingtin (htt), a large protein with features of a multi-functional scaffold. Expansion of htt's polyglutamine domain induces novel, toxic interactions and likely also disrupts normal htt function.
Jia, Yao +2 more
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Cellular and Molecular Biology of the Presynaptic Nerve Terminal
Annual Review of Neuroscience, 1991Chemical neurotransmission represents the primary form of intercellular communication in the nervous system, yet relatively little is known about the molecular processes involved. The vesicle hypothesis states that spe cialized organelles located in the synaptic region are responsible for the accumulation, storage, and release of neurotransmitters in ...
W S, Trimble, M, Linial, R H, Scheller
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Immunology of the neuromuscular junction and presynaptic nerve terminal
Current Opinion in Neurology, 1999The prevalence and incidence of myasthenia gravis is higher than previously thought. A potentially immunodominant T cell has been defined. The specific voltage-gated calcium channel subtype that is targeted by antibodies in the Lambert-Eaton myasthenic syndrome has been identified, and there is further evidence for the pathogenic role of autoantibodies
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Functional Proteins in the Presynaptic Terminal
1996Neurotransmitter release from presynaptic terminals takes place rapidly by exocytosis of synaptic vesicles. It is well established that calcium ions entering presynaptic terminals through voltage-sensitive calcium channels trigger neurotransmitter release.
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Introduction: The presynaptic terminal
Seminars in Neuroscience, 1994Heinrich Betz, George Augustine
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