Results 211 to 220 of about 51,824 (254)
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Molecular architecture of the presynaptic terminal
Current Opinion in Structural Biology, 2019Neurotransmitter release at the presynaptic terminal is one of the fundamental processes in neuronal communication. It is a complex process comprising signaling pathways that exert a precise spatio-temporal coordination to prepare and bring synaptic vesicles to exocytosis.
Benoît Zuber, Vladan Lučić
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Ultrastructural organization of presynaptic terminals
Current Opinion in Neurobiology, 2011In response to calcium influx, synaptic vesicles fuse very rapidly with the plasma membrane to release their neurotransmitter content. An important mechanism for sustained release includes the formation of new vesicles by local endocytosis. How synaptic vesicles are trafficked from the sites of endocytosis to the sites of release and how they are ...
Léa, Siksou +2 more
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Location of calcium transporters at presynaptic terminals
European Journal of Neuroscience, 2000AbstractThe plasma membrane ATP‐driven Ca2+ pump (PMCA) and the Na+/Ca2+ exchanger (NCX) are the major means of Ca2+ extrusion at presynaptic nerve terminals, but little is know about the location of these transporters relative to the major sites of Ca2+ influx, the transmitter release sites.
M, Juhaszova +3 more
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The tipsy terminal: Presynaptic effects of ethanol
Pharmacology & Therapeutics, 2005Considerable evidence suggests that the synapse is the most sensitive CNS element for ethanol effects. Although most alcohol research has focussed on the postsynaptic sites of ethanol action, especially regarding interactions with the glutamatergic and GABAergic receptors, few such studies have directly addressed the possible presynaptic loci of ...
George Robert, Siggins +2 more
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The functional landscape of a presynaptic nerve terminal
Cell Calcium, 2012The neuromuscular junction (NMJ) is the original model synapse, and while others have emerged, especially as models of plasticity involving coincidence detectors, the NMJ continues to provide useful new information. It remains, for example, one of the best understood synapses in terms of the relationship between structure and function.
Raquel, Cano +4 more
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Presynaptic terminal differentiation: transport and assembly
Current Opinion in Neurobiology, 2004The formation of chemical synapses involves reciprocal induction and independent assembly of pre- and postsynaptic structures. The major events in presynaptic terminal differentiation are the formation of the active zone and the clustering of synaptic vesicles.
Mei, Zhen, Yishi, Jin
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Currents in the presynaptic terminal arbors of barnacle photoreceptors
Visual Neuroscience, 1993AbstractWe have described the currents flowing across the presynaptic membranes of the four median photoreceptors of the giant barnacle,Balanus nubilus, using a quasi-voltage clamp arrangement. Membrane potential, measured in the terminal region of one photoreceptor, was controlled in all four terminals by feedback current supplied through the nerve ...
J H, Hayashi, A E, Stuart
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Immunocytochemical evidence for tubulin in the presynaptic terminal of synaptosomes
Neuroscience Letters, 1983Ultrastructural studies of intact tissue rarely show presynaptic microtubules, and immunocytochemical studies on tissue sections have previously been unable to demonstrate tubulin in the nerve terminal. In contrast, a microtubular coil can be readily detected in the presynaptic nerve terminal of synaptosomes.
R, Cumming +3 more
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SPARC prevents maturation of cholinergic presynaptic terminals
Molecular and Cellular Neuroscience, 2012Secreted Protein Acidic and Rich in Cysteine (SPARC) is a matricellular protein produced by glial cells. Although it is highly expressed in synaptogenic areas in the developing nervous system, it is still unclear whether this molecule displays an action on synaptic activity. We show that nanomolar concentrations of SPARC favour a more efficient synapse
David, Albrecht +5 more
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Models of the Presynaptic Terminal
1978The preceding three Sections have summarized many of the morphological aspects of current synaptology. In accomplishing this, the ground covered has included conventional synaptic morphology and a range of contemporary approaches to the presynaptic terminal.
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