Results 181 to 190 of about 2,392 (196)

Intraperitoneal Pretargeted Radioimmunotherapy for Colorectal Peritoneal Carcinomatosis

Molecular Cancer Therapeutics, 2022
Abstract Peritoneal carcinomatosis (PC) is considered incurable, and more effective therapies are needed. Herein we test the hypothesis that GPA33-directed intracompartmental pretargeted radioimmunotherapy (PRIT) can cure colorectal peritoneal carcinomatosis.
Christopher S. Chandler, Meghan M. Bell, Sebastian K. Chung, Darren R. Veach, Edward K. Fung, Blesida Punzalan, Daniela Burnes Vargas, Mitesh Patel, Hong Xu, Hong-fen Guo, Brian H. Santich, Pat B. Zanzonico, Sébastien Monette, Garrett M. Nash, Andrea Cercek, Achim Jungbluth, Neeta Pandit-Taskar, Nai Kong V. Cheung, Steven M. Larson, Sarah M. Cheal   +19 more
openaire   +2 more sources

Structural insights into metazoan pretargeting GET complexes

Nature Structural & Molecular Biology, 2021
Close coordination between chaperones is essential for protein biosynthesis, including the delivery of tail-anchored (TA) proteins containing a single C-terminal transmembrane domain to the endoplasmic reticulum (ER) by the conserved GET pathway. For successful targeting, nascent TA proteins must be promptly chaperoned and loaded onto the cytosolic ...
Alexander F. A. Keszei, Matthew C. J. Yip, Ta-Chien Hsieh, Sichen Shao   +3 more
openaire   +2 more sources

Investigations of 99mTc morpholino pretargeting in mice

Nuclear Medicine Communications, 2003
This laboratory is exploring the use of morpholinos (MORFs), synthetic DNA analogues, for nuclear medicine applications, including pretargeting. The anti-CEA antibody MN14 was conjugated with an 18 mer MORF and with diethylenetriaminepentaacetic acid (DTPA) for 111In labelling.
G, Liu, C, Liu, S, Zhang, J, He, N, Liu, S, Gupta, M, Rusckowski, D J, Hnatowich   +7 more
openaire   +2 more sources

PEGylation of Yeast Cytosine Deaminase for Pretargeting

Journal of Pharmaceutical Sciences, 2005
Yeast cytosine deaminase (yCD) was cloned, expressed, and purified by affinity chromatography. We have characterized the products resulting from covalent attachment of 2-4 PEG chains on yCD and determined the major and minor isomers for each respective conjugate.
May P, Xiong, Glen S, Kwon
openaire   +2 more sources

Pretargeted imaging using bioorthogonal chemistry in mice

Current Opinion in Chemical Biology, 2014
Following the successful application of in vivo chemistry in chemical biology there has been growing interest in extending the application scope to non-invasive molecular imaging and therapy in living animals and eventually humans. A typical example of such an application is pretargeted radioimmuno-imaging and -therapy: the tumor targeting of a tagged ...
Raffaella, Rossin, Marc S, Robillard
openaire   +2 more sources

Pretargeted Radioimmunotherapy with α-Particle Emitting Radionuclides

Current Radiopharmaceuticalse, 2011
Alpha-particle emitting radionuclides are attractive for targeted cancer therapies due to their physicochemical properties. Their high linear energy transfer (LET) and short particle range makes them particularly toxic at a microscopic level, which is ideal for treating disseminated micrometastases.
Sture, Lindegren, Sofia H L, Frost
openaire   +2 more sources

Intraperitoneal Pretarget Radioimmunotherapy with CC49 Fusion Protein

Clinical Cancer Research, 2005
Abstract Purpose: This study examined a pretarget radioimmunotherapy strategy for treatment of an i.p. tumor model (LS174T). Experimental Design: The strategy used regional administration (i.p.) of a novel targeting molecule composed of four CC49 anti–tumor-associated glycoprotein 72 (TAG-72) single-chain antibodies linked
Donald J, Buchsbaum, M B, Khazaeli, Donald B, Axworthy, Jody, Schultz, Tandra R, Chaudhuri, Kurt R, Zinn, Mark, Carpenter, Albert F, LoBuglio   +7 more
openaire   +2 more sources

Use of Morpholino Oligomers for Pretargeting

2017
Differing from the conventional direct-targeting strategy in which a probe or payload is directly loaded onto a targeting molecule that binds to the native target, pretargeting is an improved targeting strategy. It converts the native target to an artificial target specific for a secondary targeting molecule loaded with the probe or payload (effector).
openaire   +3 more sources

Expression-Dependent Tumor Pretargeting via Engineered Avidity

Molecular Pharmaceutics
Selective delivery of therapeutic modalities to tumor cells via binding of tumor-selective cell-surface biomarkers has empowered substantial advances in cancer treatment. Yet, tumor cells generally lack a truly specific biomarker that is present in high density on tumor tissue while being completely absent from healthy tissue.
Abbigael Harthorn, Tse-Han Kuo, Sarah W. Torres, Roy R. Lobb, Benjamin J. Hackel   +4 more
openaire   +2 more sources

Radioimmunotherapy: Is avidin-biotin pretargeting the preferred choice among pretargeting methods?

European Journal of Nuclear Medicine and Molecular Imaging, 2003
David M, Goldenberg, Chien-Hsing, Chang, Robert M, Sharkey, Edmund A, Rossi, Habibe, Karacay, William, McBride, Hans J, Hansen, Jean-Francois, Chatal, Jacques, Barbet   +8 more
openaire   +4 more sources