Results 51 to 60 of about 16,193 (191)

Malaria in Bangladesh, 2000–2025: Navigating the Headwinds From Control to Elimination

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Bangladesh has dramatically reduced its malaria burden since 2000, confining the disease to specific geographic zones. However, the national 2030 elimination goal is now threatened by a complex interplay of biological, ecological, and social factors.
Abdullaha Al Mamun, Mustafa Sarwar A. Kayenat, K. A. M. Inzamul Islam   +2 more
wiley   +1 more source

An increase in urinary primaquine and a reduction in urinary primaquine-5,6-orthoquinone in the Thai population with CYP2D6 reduced enzyme function

Heliyon
Objectives: Primaquine is metabolized by the cytochrome P450-2D6 enzyme (CYP2D6) to an active primaquine-5,6-orthoquinone (POQ). No relationships of CYP2D6 polymorphisms with the pharmacokinetics of primaquine and POQ were reported in the Thai population.
Waritda Pookmanee, Siriwan Thongthip, Mathirut Mungthin, Chonlaphat Sukasem, Jeeranut Tankanitlert, Pajaree Chariyavilaskul, Supeecha Wittayalertpanya   +6 more
doaj   +1 more source

Modelling primaquine-induced haemolysis in G6PD deficiency

eLife, 2017
Primaquine is the only drug available to prevent relapse in vivax malaria. The main adverse effect of primaquine is erythrocyte age and dose-dependent acute haemolytic anaemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd).
James Watson, Walter RJ Taylor, Didier Menard, Sim Kheng, Nicholas J White   +4 more
doaj   +1 more source

Genomic Insights Into Host Shifts Between Plasmodium vivax and Plasmodium simium in Latin America

Evolutionary Applications, Volume 19, Issue 3, March 2026.
ABSTRACT Malaria in Latin America is largely caused by Plasmodium vivax, but the closely related monkey parasite Plasmodium simium has recently been observed in humans, thus raising new public health concerns. By screening 719 monkey samples from five Latin America countries, we identified 23 Plasmodium‐positives.
Margaux J. M. Lefebvre, Fanny Degrugillier, Céline Arnathau, Camila González, Silvia Rondón, Andrés Link, Andrea Chaves, Julio A. Benavides, Aline Alves Scarpellini Campos, Edmilson dos Santos, Rosana Huff, Cláudia Maria Dornelles da Silva, Ezequiel Vanderhoeven, Benoit De Thoisy, Michael C. Fontaine, Franck Prugnolle, Virginie Rougeron   +16 more
wiley   +1 more source

Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial

Malaria Journal, 2019
Background To reduce onward falciparum malaria transmission, the World Health Organization recommends adding single low-dose (SLD) primaquine to artemisinin-based combination treatment in low transmission areas. However, uptake of this recommendation has
Jaishree Raman, Elizabeth Allen, Lesley Workman, Aaron Mabuza, Hendrik Swanepoel, Gillian Malatje, John Frean, Lubbe Wiesner, Karen I. Barnes   +8 more
doaj   +1 more source

Safety and efficacy of primaquine in patients with Plasmodium vivax malaria from South Asia: a systematic review and individual patient data meta-analysis

BMJ Global Health, 2023
Background The optimal dosing of primaquine to prevent relapsing Plasmodium vivax malaria in South Asia remains unclear. We investigated the efficacy and safety of different primaquine regimens to prevent P.
Philippe J Guérin, Kavitha Saravu, Julie A Simpson, Bipin Adhikari, Komal Raj Rijal, Prakash Ghimire, Mark Rowland, Sasithon Pukrittayakamee, Amit Sharma, Manju Rahi, Praveen K Bharti, Ric N Price, Megha Rajasekhar, Toby Leslie, Reena Verma, Rishikesh Kumar, Sauman Singh-Phulgenda, Robert J Commons, Apoorv Gupta, Nitika, Kamala Thriemer, Mohammad Shafiul Alam, Wasif A Khan, Benedikt Ley, Alejandro Llanos-Cuentas   +24 more
doaj   +1 more source

A reiterative method for calculating the early bactericidal activity of antituberculosis drugs.

, 2002
Studies of early bactericidal activity (EBA) are important in the rapid evaluation of new antituberculosis drugs. Historically, these have concentrated on the log fall in the viable count in sputum during the first 48 hours of therapy.
Charalambous, Bambos M, Gillespie, Stephen H, Gosling, Roland D   +2 more
core   +1 more source

Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children [PDF]

, 2017
Low-dose primaquine is recommended to prevent Plasmodium falciparum malaria transmission in areas threatened by artemisinin resistance and areas aiming for malaria elimination.
Bousema, Teun, Drakeley, Chris, Goncalves, Bronner P., Murry, Daryl, Niemi, Mikko, Pett, Helmi, Sirima, Sodiomon B., ter Heine, Rob, Tiono, Alfred B.   +8 more
core   +2 more sources

Antimalarial Polyethylene Glycol–Lumefantrine Conjugates: Synthesis and Effect of Linker Chemistry on Drug Release

Advanced Therapeutics, Volume 9, Issue 2, February 2026.
Research into advanced therapeutics for malaria are rare. We investigate how linker chemistry governs the release kinetics of the antimalarial lumefantrine from polyethylene glycol conjugates. A clear correlation between diacid linker length and drug release rate is established, enabling rational design of conjugates with controlled release.
Thenesia R. Govender, William M. R. Matshe, Nokuthula Dube, Zamani E. D. Cele, Aurelia A. Williams, Lynne A. Pilcher, Mohammed O. Balogun   +6 more
wiley   +1 more source

Access to primaquine in the last mile: challenges at the service delivery points in pre-elimination era, Myanmar

Tropical Medicine and Health, 2018
Background Alongside monitoring of the disease burden, the successful move towards malaria elimination relies on the readiness of the health care delivery system.
Kay Thwe Han, Khin Thet Wai, Tin Oo, Aung Thi, Zayar Han, Daw Kyin Hla Aye, Aung Ye Naung Win, Jetsumon Prachumsri   +7 more
doaj   +1 more source