Results 51 to 60 of about 14,994 (162)

Costs Associated with Malaria in Pregnancy in the Brazilian Amazon, a Low Endemic Area Where Plasmodium vivax Predominates. [PDF]

, 2016
BACKGROUND: Information on costs associated with malaria in pregnancy (MiP) in low transmission areas where Plasmodium vivax predominates is so far missing. This study estimates health system and patient costs of MiP in the Brazilian Amazon.
Bardají, A, Bôtto-Menezes, C, Dos Santos Campos, G, Fernandes, S, Hanson, K, Martínez-Espinosa, FE, Menéndez, C, Sicuri, E   +7 more
core   +4 more sources

Network Medicine‐Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD‐L1 Expression via Targeting SPOP in Cancer

Advanced Science, Volume 12, Issue 1, January 9, 2025.
A network‐based computational framework known as Mnet‐DRI is developed to accurately identify maprotiline, an antidepressant, as a potential PD‐L1 inhibitor for use in colorectal and lung cancers. A series of experiments are conducted to demonstrate that maprotiline targets SPOP, resulting in the degradation of PD‐L1 and the activation of T cells ...
Saisai Tian, Mengting Xu, Xiangxin Geng, Jiansong Fang, Hanchen Xu, Xinying Xue, Hongmei Hu, Qing Zhang, Dianping Yu, Mengmeng Guo, Hongwei Zhang, Jinyuan Lu, Chengyang Guo, Qun Wang, Sanhong Liu, Weidong Zhang   +15 more
wiley   +1 more source

Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial [PDF]

, 2016
Background: A single low dose (0.25 mg/kg) of primaquine is recommended as a gametocytocide in combination with artemisinin-based combination therapies for Plasmodium falciparum but its effect on post-treatment gametocyte circulation and infectiousness ...
A Ouedraogo, AC Eziefula, Alfred B. Tiono, Alice C. Eziefula, Alphonse Ouédraogo, AM Dondorp, Amidou Diarra, Bronner P. Gonçalves, C Harris, Chris Drakeley, CJ Sutherland, Débé Siaka, EA Ashley, EA Ashley, Edith C. Bougouma, G Targett, HC Slater, Helmi Pett, I Chen, Issa Nebie, J Gerardin, JM Bolscher, John Bradley, JT Bousema, Kjerstin Lanke, MJ Delves, NJ White, NJ White, P Sawa, P Schneider, P Schneider, R Wampfler, RE Paul, SA Shekalaghe, SH Adjalley, Sodiomon B. Sirima, T Bousema, T Bousema, T Bousema, Teun Bousema, TS Churcher, V Robert, W Stone, Wamdaogo M. Guelbéogo   +43 more
core   +7 more sources

13C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications

Chemistry–Methods, Volume 5, Issue 1, January 2025.
Synthesis of 13C‐labeled compounds was a separate field in chemistry. Now, incorporation of 13C label is a useful approach in structure determination of complicated compounds, catalysis, mechanistic investigations, biochemistry and metabolomics. In this review, carbon‐13 labeling was considered as a method in chemistry, providing efficient routes in ...
Konstantin S. Rodygin, Alexander S. Bogachenkov, Yulia V. Gyrdymova, Anton N. Potorochenko   +3 more
wiley   +1 more source

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth [PDF]

, 2015
Malaria is a major health burden in tropical and subtropical countries. The antimalarial drug primaquine is extremely useful for killing the transmissible gametocyte forms of Plasmodium falciparum and the hepatic quiescent forms of P. vivax.
Alhebshi, Balk, Beaudoin, Bonneaud, Boulard, Bousema, Chen, Cohen, Delves, Dembele, Dujardin, Flint, Fridovich, Ganesan, Gratepanche, Groitl, Hall, Hanschmann, Harris, Hausladen, Howells, Imlay, Ke, Krebs, Lanners, Lee, Macomber, MacRae, Magwere, Marchler-Bauer, McCord, Meineke, Meyer, Miller, Müller, Navas, Nürenberg, Patel, Pied, Potter, Pybus, Pybus, Racker, Ravindranath, Shekalaghe, Strain, Umbreit, Vale, Van Dooren, Vasquez-Vivar, Wallace, Weisiger, WHO, Woods   +53 more
core   +4 more sources

Structure of Plasmodium vivaxN‐myristoyltransferase with inhibitor IMP‐1088: exploring an NMT inhibitor for antimalarial therapy

Acta Crystallographica Section F, Volume 81, Issue 1, Page 1-10, January 2025.
The 1.8 Å resolution ternary structure of P. vivaxN‐myristoyltransferase in complex with IMP‐1088 and myristoyl‐CoA is presented. IMP‐1088 is an N‐myristoyltransferase inhibitor from a family of inhibitors that are under investigation as antimalarials.Plasmodium vivax, a significant contributor to global malaria cases, poses an escalating health burden
Alex Mendez, Cydni Bolling, Shane Taylor, Stanley Makumire, Bart Staker, Alexandra Reers, Brad Hammerson, Stephen J. Mayclin, Jan Abendroth, Donald D. Lorimer, Thomas E. Edwards, Edward W. Tate, Sandhya Subramanian, Andrew S. Bell, Peter J. Myler, Oluwatoyin A. Asojo, Graham Chakafana   +16 more
wiley   +1 more source

Short-term antigen presentation and single clonal burst limit the magnitude of the CD8(+) T cell responses to malaria liver stages.

, 2002
Malaria sporozoites induce swift activation of antigen-specific CD8(+) T cells that inhibit the intracellular development of liver-stage parasites. The length of time of functional in vivo antigen presentation, estimated by monitoring the activation of ...
A. Morrot, Ahmed, Altman, Bruno, Bru  a-Romero, Busch, Carvalho, Carvalho, Clyde, F. Zavala, G.-i. Sano, Gilbert, Goossens, Gray, Herrington, Hou, J. C. R. Hafalla, Kaech, Kundig, L. H. Carvalho, Lalvani, Lau, Li, Mercado, Mullbacher, Murali-Krishna, Oehen, Oliveira-Ferreira, Plebanski, Plebanski, Renggli, Rodrigues, Rodrigues, Rodrigues, Rodrigues, Romero, Scheller, Schneider, Sedegah, Shinkai, Tanchot, van Stipdonk, Vanderberg, Veiga-Fernandes, Weiss   +44 more
core   +2 more sources

Primaquine plus artemisinin combination therapy for reduction of malaria transmission: promise and risk [PDF]

, 2016
Reduction of gametocyte transmission from humans to mosquitoes is a key component of malaria elimination. The study by Gonçalves and colleagues provides valuable new data on how the addition of low-dose primaquine to artemether-lumefantrine affects ...
John, Chandy C.
core   +1 more source

Nanoformulation and Preclinical Evaluation of Dihydroartemisinin–Lumefantrine and Primaquine as Combined Antimalarial Therapy

Journal of Nanotechnology, Volume 2025, Issue 1, 2025.
The World Health Organization recommends artemisinin‐based combinations for uncomplicated malaria treatment. Artemether and lumefantrine (LUM) are the first‐line treatments, with artemether serving as a prodrug of dihydroartemisinin (DHA), while primaquine (PQ) is primarily used as a prophylactic drug.
Pesila Odera, Geoffrey Otieno, Joab Onyango, Bernhards Ogutu, James Owour, Florence Oloo, Martin Ongas, Hulda Swai, Jeremiah Gathirwa, Arnab Biswas   +9 more
wiley   +1 more source

Gametocytes: insights gained during a decade of molecular monitoring [PDF]

, 2008
In vertebrate hosts, malaria parasites produce specialized male and female sexual stages (gametocytes). Soon after being taken up by a mosquito, gametocytes rapidly produce gametes and, once mated, they infect their vector and can be transmitted to new ...
Abdel-Wahab, Akim, Alano, Ali, Babiker, Babiker, Babiker, Babiker, Bell, Billingsley, Bonnet, Boudin, Bousema, Bousema, Bousema, Buckling, Buckling, Buckling, de Roode, Dixon, Drakeley, Drew, Dunyo, Dye, El-Sayed, Farnert, Farnert, Ferguson, Gaillard, Gardner, Gautret, Graves, Hamza A. Babiker, Hill, Huber, Jarvi, Jeffery, Kooij, Menegon, Mideo, Nassir, Nee, Niederwieser, Nwakanma, Okell, Osorio, Ouédraogo, Paganotti, Paul, Paul, Paul, Paul, Petra Schneider, Pichon, Pradel, Read, Reece, Reece, Robert, Sarah E. Reece, Schall, Schall, Schneider, Schneider, Schneider, Shekalaghe, Shekalaghe, Shutler, Shutler, Smith, Sokhna, Sowunmi, Talman, Talman, Targett, Trager, Vardo, Wargo, Wargo, Wargo, Werren, West   +81 more
core   +2 more sources