Results 61 to 70 of about 95,754 (365)

Sarcoidosis and primary biliary cholangitis in a patient with cholestasis

Терапевтический архив, 2021
Primary biliary cholangitis and sarcoidosis are both cholestatic liver diseases. Currently, there are no established specific criteria for distinguishing the diseases from each other; diagnosis is based on the anamnesis, as well as the results of ...
M. Yu. Brovko, L. A. Akulkina, M. V. Kalashnikov, T. P. Rozina, T. P. Nekrasova, V. I. Sholomova, D. V. Konovalov, A. Sh. Yanakayeva, S. V. Moiseev   +8 more
doaj   +1 more source

Impact of Pruritus on Quality of Life and Current Treatment Patterns in Patients with Primary Biliary Cholangitis

Digestive Diseases and Sciences, 2022
Background and Aims Patients with primary biliary cholangitis (PBC) often suffer with pruritus. We describe the impact of pruritus on quality of life and how it is managed in a real-world cohort.
M. Mayo, Elizabeth J Carey, Helen T. Smith, Andrea R. Mospan, M. McLaughlin, A. Thompson, H. Morris, Robert Sandefur, W. Kim, C. Bowlus, Victor David Brian Christopher Robert Elizabeth Virginia Ankoma-Sey Bernstein Borg Bowlus Brown Carey Clark, V. Ankoma‐Sey, D. Bernstein, B. Borg, C. Bowlus, Robert Brown, Elizabeth J Carey, V. Clark, J. Darling, J. Dranoff, Hany Elbeshbeshy, L. Forman, A. Goel, J. Hanje, S. Harrison, Sujit Janardhan, R. Jesudoss, David Kim, Lindsay Y King, C. Landis, Cynthia Levy, A. Lok, M. Lucey, V. Luketic, Richard A. Manch, W. Mark, M. Mayo, E. Mena, A. Modi, G. Reddy, K. Reddy, F. Rochling, S. Rojter, R. Rubin, M. Russo, Mitchell Shiffman, M. Silveira, C. Stanca, P. Thuluvath, E. Verna, L. Weiss, Cynthia Levy   +51 more
semanticscholar   +1 more source

A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis. [PDF]

, 2019
Primary biliary cholangitis (PBC) is typically associated with elevated serum bile acid levels and pruritus, but pruritus is often refractory to treatment with existing therapies.
Apostol, George, Bacon, Bruce, Bowlus, Christopher L, Dorenbaum, Alejandro, Gu, Joan, Hirschfield, Gideon M, Jones, David, Kennedy, Ciara, Levy, Cynthia, Luketic, Velimir, Mayo, Marlyn J, Medendorp, Sharon, Novak, Patricia, Patanwala, Imran, Pockros, Paul J, Vuppalanchi, Raj   +15 more
core   +2 more sources

Low vitamin D concentrations and BMI are causal factors for primary biliary cholangitis: A mendelian randomization study

Frontiers in Immunology, 2022
Backgrounds Observational studies have identified associations between smoking, alcohol use, body mass index (BMI), and the levels of vitamin D with primary biliary cholangitis (PBC). However, there was a lack of randomization control studies to estimate
Honglin Xu, Ziyan Wu, F. Feng, Yongzhe Li, Shulan Zhang   +4 more
semanticscholar   +1 more source

Evaluation of the primary biliary cholangitis-related serologic profile in a large cohort of Belgian systemic sclerosis patients [PDF]

, 2020
Background: Systemic sclerosis (SSc) and primary biliary cholangitis (PBC) are autoimmune diseases that may occur concomitantly and are both strongly associated with disease-specific autoantibodies.
Bonroy, Carolien, De Keyser, Filip, Devreese, Katrien, Florin, Lisa, Rubben, Kaat, Smith, Vanessa, Vanhaecke, Amber   +6 more
core   +1 more source

Difficulties in Diagnosing Isolated IgG4-associated Sclerosing Cholangitis

Journal of Digestive Endoscopy, 2019
The most common causes of recurrent cholangitis are biliary stones and neoplasia. Primary types of sclerosing cholangitis such as IgG4-associated sclerosing cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC) are rare causes of recurrent ...
Gábor Zsóri, Dóra Illés, László Tiszlavicz, László Czakó   +3 more
doaj   +1 more source

Management of Autoimmune Liver Diseases after Liver Transplantation

Transplantology, 2021
Autoimmune liver diseases are characterized by immune-mediated inflammation and eventual destruction of the hepatocytes and the biliary epithelial cells. They can progress to irreversible liver damage requiring liver transplantation.
Romelia Barba Bernal, Esli Medina-Morales, Daniela Goyes, Vilas Patwardhan, Alan Bonder   +4 more
doaj   +1 more source

COBALT: A Confirmatory Trial of Obeticholic Acid in Primary Biliary Cholangitis With Placebo and External Controls

American Journal of Gastroenterology
INTRODUCTION: Obeticholic acid (OCA) treatment for primary biliary cholangitis (PBC) was conditionally approved in the phase 3 POISE trial. The COBALT confirmatory trial assessed whether clinical outcomes in patients with PBC improve with OCA therapy ...
Kris V. Kowdley, G. Hirschfield, Charles Coombs, E. Malecha, Leona Bessonova, Jing Li, N. Rathnayaka, G. Mells, David Jones, Palak J. Trivedi, Bettina Hansen, Rachel Smith, J. Wason, S. Hiu, D. Kareithi, A.L. Mason, C. Bowlus, Kate Muller, Marco Carbone, Marina Berenguer, P. Milkiewicz, F. Adekunle, A. Villamil   +22 more
semanticscholar   +1 more source

The microbiota of the bilio-pancreatic system: A cohort, STROBE-compliant study [PDF]

, 2019
Background: The gut microbiota play an essential role in protecting the host against pathogenic microorganisms by modulating immunity and regulating metabolic processes.
Agrusa A., D'arpa F., Di Carlo P., Fasciana T., Giammanco A., Gulotta G., Rodolico V., Sergi C., Serra N.   +8 more
core   +1 more source

Autotaxin: A Potential biomarker for primary biliary cholangitis

Heliyon
Background: In some patients especially those AMA negative, the diagnosis may be a challenge requiring liver biopsy. This study determined whether autotaxin, a secreted lysophospholipase D encoded by the exonucleotide pyrophosphatase phosphodiesterase 2 ...
Yifei Yang, Bingqian Liu, Bo Zang, Qixuan Liu, Chenyang Zhao, Yuan Yao, Bin Liu   +6 more
doaj   +1 more source