Results 101 to 110 of about 4,821,890 (183)

Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]

, 2016
The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina, John, Emily, Mahjoub, Moe R, Mitchell, Brian J, Moresco, James J, Silva, Erica, Spear, Philip, Yates, John R, III, Zhang, Siwei   +8 more
core   +2 more sources

Ventromedial hypothalamic primary cilia control energy and skeletal homeostasis.

Journal of Clinical Investigation, 2020
Dysfunction of primary cilia is related to dyshomeostasis, leading to a wide range of disorders. The ventromedial hypothalamus (VMH) is known to regulate several homeostatic processes, but those modulated specifically by VMH-primary cilia are not yet ...
Ji Su Sun, D. Yang, Ann W. Kinyua, S. Yoon, J. Seong, Juwon Kim, S. J. Moon, D. Shin, Yun-Hee Choi, Ki Woo Kim   +9 more
semanticscholar   +1 more source

Direct recording and molecular identification of the calcium channel of primary cilia [PDF]

, 2014
Summary A primary cilium is a solitary slender non-motile protuberance of structured microtubules (9+0) enclosed by plasma membrane1. Housing components of the cell division apparatus between cell divisions, they also serve as specialized compartments ...
Clapham, David E., DeCaen, Paul G., Delling, Markus, Vien, Thuy N.   +3 more
core   +1 more source

Reciprocal Regulation between Primary Cilia and mTORC1

Genes, 2020
In quiescent cells, primary cilia function as a mechanosensor that converts mechanic signals into chemical activities. This unique organelle plays a critical role in restricting mechanistic target of rapamycin complex 1 (mTORC1) signaling, which is ...
Yandong Lai, Yu Jiang
semanticscholar   +1 more source

Fibroblast Primary Cilia Are Required for Cardiac Fibrosis.

Circulation, 2019
BACKGROUND The primary cilium is a singular cellular structure that extends from the surface of many cell types and plays crucial roles in vertebrate development, including that of the heart. Whereas ciliated cells have been described in developing heart,
Elisa Villalobos, A. Criollo, G. Schiattarella, Francisco Altamirano, Kristin M. French, Herman I. May, Nan Jiang, N. Nguyen, Diego Romero, J. Roa, Lorena García, G. Díaz-Araya, E. Morselli, A. Ferdous, S. Conway, Hesham A. Sadek, T. Gillette, S. Lavandero, Joseph A. Hill   +18 more
semanticscholar   +1 more source

The ciliary GTPase Arl13b regulates cell migration and cell cycle progression [PDF]

, 2016
Acknowledgments We acknowledge Prof. Tamara Caspary from Emory University for kindly providing the cell lines, Linda Duncan from the University of Aberdeen Ian Fraser Cytometry Center for help with flow cytometry.
Clancy, Hannah, Ding, Yu-Qiang, Lang, Bing, McCaig, Colin D., Pruski, Michal, Rajnicek, Ann, Yang, Zhifu   +6 more
core   +2 more sources

Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCC

Cell Death and Disease
Primary cilia are present on renal tubules and are implicated to play a pivotal role in transducing signals during development; however, the oncogenic role of cilia in clear cell renal cell carcinoma (ccRCC) has not been examined.
Shuo Tian, Songliang Du, Chenfeng Wang, Yu Zhang, Hanfeng Wang, Yang Fan, Yu Gao, Liangyou Gu, Qingbo Huang, Baojun Wang, Xin Ma, Xu Zhang, Yan Huang   +12 more
doaj   +1 more source

ciliaFA : a research tool for automated, high-throughput measurement of ciliary beat frequency using freely available software [PDF]

, 2012
Background: Analysis of ciliary function for assessment of patients suspected of primary ciliary dyskinesia (PCD) and for research studies of respiratory and ependymal cilia requires assessment of both ciliary beat pattern and beat frequency.
C O’Callaghan, CL O’Callaghan, CM Smith, CW Wilson, EE Davis, G Mantovani, JH Sisson, JJ Ballenger, JR Kennedy, M Ryser, MA Chilvers, MA Chilvers, RA Hirst, RA Hirst, RA Hirst, S Dimova, TJ Mitchell, WA Stannard, WI Lee, WS Rasband   +19 more
core   +1 more source

Primary cilia as the nexus of biophysical and hedgehog signaling at the tendon enthesis

Science Advances, 2020
Primary cilia at the tendon enthesis serve as mechanosensors and Hh signal transducers. The tendon enthesis is a fibrocartilaginous tissue critical for transfer of muscle forces to bone.
Fei Fang, A. Schwartz, E. Moore, McKenzie E. Sup, S. Thomopoulos   +4 more
semanticscholar   +1 more source

Structure, function, and research progress of primary cilia in reproductive physiology and reproductive diseases

Frontiers in Cell and Developmental Biology
Primary cilia, serving as the central hub for cellular signal transduction, possess the remarkable ability to translate diverse extracellular signals, both chemical and mechanical, into intracellular responses.
Xiaochuan Long, Xiaochuan Long, Li Chen, Li Chen, Xinyao Xiao, Xinyao Xiao, Xiayu Min, Xiayu Min, Yao Wu, Yao Wu, Zengming Yang, Zengming Yang, Xin Wen, Xin Wen   +13 more
doaj   +1 more source