Structure, interaction and nervous connectivity of beta cell primary cilia [PDF]
Nature CommunicationsPrimary cilia are sensory organelles present in many cell types, partaking in various signaling processes. Primary cilia of pancreatic beta cells play pivotal roles in paracrine signaling and their dysfunction is linked to diabetes.
Andreas Müller +21 more
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Roles of Primary Cilia in the Developing Brain
Frontiers in Cellular Neuroscience, 2019 Essential to development, primary cilia are microtubule-based cellular organelles that protrude from the surface of cells. Acting as cellular antenna, primary cilia play central roles in transducing or regulating several signaling pathways, including ...
Sang Min Park +3 more
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Structure, function, and research progress of primary cilia in reproductive physiology and reproductive diseases [PDF]
Frontiers in Cell and Developmental BiologyPrimary cilia, serving as the central hub for cellular signal transduction, possess the remarkable ability to translate diverse extracellular signals, both chemical and mechanical, into intracellular responses.
Xiaochuan Long +13 more
doaj +2 more sources
Asymmetric Distribution of Primary Cilia Allocates Satellite Cells for Self-Renewal [PDF]
Stem Cell Reports, 2016 Summary: Regeneration of vertebrate skeletal muscles requires satellite cells, a population of stem cells that are quiescent in normal conditions and divide, differentiate, and self-renew upon activation triggered by exercise, injury, and degenerative ...
Nur Hayati Jaafar Marican +2 more
doaj +5 more sources
Calprotectin: An Ignored Biomarker of Neutrophilia in Pediatric Respiratory Diseases
Children, 2021 Calprotectin (CP) is a non-covalent heterodimer formed by the subunits S100A8 (A8) and S100A9 (A9). When neutrophils become activated, undergo disruption, or die, this abundant cytosolic neutrophil protein is released.
Grigorios Chatziparasidis, Ahmad Kantar
doaj +1 more source
Primary cilia as dynamic and diverse signalling hubs in development and disease
Nature reviews genetics, 2023 Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate cell types, are essential for regulating signalling pathways during development and adult homeostasis.
P. Mill, S. Christensen, L. B. Pedersen
semanticscholar +1 more source
Primary cilia sense glutamine availability and respond via asparagine synthetase
Nature Metabolism, 2023 Depriving cells of nutrients triggers an energetic crisis, which is resolved by metabolic rewiring and organelle reorganization. Primary cilia are microtubule-based organelles at the cell surface, capable of integrating multiple metabolic and signalling ...
Maria Elena Steidl +15 more
semanticscholar +1 more source
Emerging principles of primary cilia dynamics in controlling tissue organization and function
EMBO Journal, 2023 Primary cilia project from the surface of most vertebrate cells and are key in sensing extracellular signals and locally transducing this information into a cellular response.
Jay Gopalakrishnan +12 more
semanticscholar +1 more source
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
Nature Communications, 2022 Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological mechanisms remain poorly understood.
Sebastian Schmidt +23 more
semanticscholar +1 more source
Primary cilia control translation and the cell cycle in medulloblastoma
Genes & Development, 2022 Here, Youn et al. investigated how the primary cilium contributes to tumorigenesis and show that primary cilia are abundant in SHH and WNT medulloblastomas, but rare in G3 and G4 medulloblastomas, from 111 cases. Their findings reveal tumor type-specific
Y. Youn +10 more
semanticscholar +1 more source