Results 31 to 40 of about 4,897,490 (257)
The Multifaceted Roles of Primary Cilia in the Development of the Cerebral Cortex
Frontiers in Cell and Developmental Biology, 2021 The primary cilium, a microtubule based organelle protruding from the cell surface and acting as an antenna in multiple signaling pathways, takes center stage in the formation of the cerebral cortex, the part of the brain that performs highly complex ...
K. Hasenpusch‐Theil, T. Theil
semanticscholar +1 more source
Primary cilia: a novel research approach to overcome anticancer drug resistance
Frontiers in Molecular Biosciences, 2023 Primary cilia are cellular organelles that consist of a microtubule skeleton surrounded by a membrane filled with cell signaling receptors. Many studies have shown that primary cilia are cellular antennas, which serve as signaling hubs and their assembly
Kyung Ho Lee, Kyung Ho Lee
doaj +1 more source
Hydrodynamic synchronisation in strong confinement [PDF]
, 2021 Cellular appendages conferring motility, such as flagella or cilia, are known to synchronise their periodic beats. The origin of synchronisation is a combination of long-range hydrodynamic interactions with physical mechanisms allowing the phases of these biological oscillators to evolve.
arxiv +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The trabecular meshwork is the major tissue regulating intraocular pressure (IOP). Malfunction of this tissue results in ocular hypertension, the major risk factor for glaucoma.
M. Shim +3 more
semanticscholar +1 more source
Synchronization in cilia carpets and the Kuramoto model with local coupling: breakup of global synchronization in the presence of noise [PDF]
published in: Chaos: An Interdisciplinary Journal of Nonlinear
Science 32:013124, 2022, 2021 Carpets of beating cilia represent a paradigmatic example of self-organized synchronization of noisy biological oscillators, characterized by traveling waves of cilia phase. We present a multi-scale model of a cilia carpet, which comprises realistic hydrodynamic interactions between cilia computed for a chiral cilia beat pattern from unicellular ...
arxiv +1 more source
Primary Cilia and Centrosomes in Neocortex Development
Frontiers in Neuroscience, 2021 During mammalian brain development, neural stem and progenitor cells generate the neurons for the six-layered neocortex. The proliferative capacity of the different types of progenitor cells within the germinal zones of the developing neocortex is a ...
Michaela Wilsch-Bräuninger, W. Huttner
semanticscholar +1 more source
Thermodynamic cost of synchronizing a population of beating cilia [PDF]
J. Stat. Mech. (2020) 074001, 2020 Synchronization among arrays of beating cilia is one of the emergent phenomena in biological processes at meso-scopic scales. Strong inter-ciliary couplings modify the natural beating frequencies, $\omega$, of individual cilia to produce a collective motion that moves around a group frequency $\omega_m$.
arxiv +1 more source
Primary cilia control glucose homeostasis via islet paracrine interactions
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The primary cilium is a small subcompartment of the cell but has powerful influence on pancreatic islet function. In this study, we find a critical role for cilia in regulating β-cell function and energy metabolism. Importantly, the deletion
Jing W. Hughes +8 more
semanticscholar +1 more source
Role of Primary Cilia in Bone and Cartilage
Journal of dentistry research, 2021 The primary cilium is a nonmotile microtubule-based organelle in most vertebrate cell types. The primary cilium plays a critical role in tissue development and homeostasis by sensing and transducing various signaling pathways.
Z. Chinipardaz +3 more
semanticscholar +1 more source
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]
, 2012 Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
A. K. T. Wann +51 more
core +2 more sources