Results 71 to 80 of about 4,909,079 (394)

HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells

open access: yesCancers, 2021
Simple Summary Glioblastoma is the most common and lethal brain tumor in adults because it becomes resistant to virtually every treatment. Histone deacetylase 6 (HDAC6), which is located primarily in the cytoplasm, has a unique role in promoting the ...
P. Shi   +9 more
semanticscholar   +1 more source

Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures [PDF]

open access: yes, 2019
Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of ...
Antonellis, Patrick J.   +7 more
core   +1 more source

Primary Cilium Identifies a Quiescent Cell Population in the Human Intestinal Crypt

open access: yesCells, 2023
Primary cilia are sensory antennae located at the cell surface which mediate a variety of extracellular signals involved in development, tissue homeostasis, stem cells and cancer.
Blanche Sénicourt   +6 more
doaj   +1 more source

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

open access: yes, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
AC Lin   +60 more
core   +1 more source

The Roles of Primary cilia in Polycystic Kidney Disease

open access: yesAIMS Molecular Science, 2013
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited genetic disorder that results in progressive renal cyst formation with ultimate loss of renal function and other systemic disorders.
Sarmed H. Kathem   +2 more
doaj   +1 more source

Ionizing radiation promotes primary ciliogenesis in glioblastoma cells

open access: yesFushe yanjiu yu fushe gongyi xuebao, 2021
The aim of this study was to investigate the effects of ionizing radiation (IR) on ciliogenesis of human glioblastoma cells. The glioblastoma cell lines M059K and M059J were exposed to X-ray or carbon ion at different doses, and the incidence and length ...
MA Wei   +5 more
doaj   +1 more source

Evaluating efficiency and robustness in cilia design [PDF]

open access: yesPhys. Rev. E 93, 033119 (2016), 2015
Motile cilia are used by many eukaryotic cells to transport flow. Cilia-driven flows are important to many physiological functions, yet a deep understanding of the interplay between the mechanical structure of cilia and their physiological functions in healthy and diseased conditions remains elusive.
arxiv   +1 more source

Visualization of Astrocytic Primary Cilia in the Mouse Brain by Immunofluorescent Analysis Using the Cilia Marker Arl13b [PDF]

open access: yes, 2014
In vertebrates, almost all somatic cells extend a single immotile cilium, referred to as a primary cilium. Increasing evidence suggests that primary cilia serve as cellular antennae in many types of tissues by sensing chemical or mechanical stimuli in ...
Asanuma, Masato   +4 more
core   +1 more source

Primary Cilia and the Cell Cycle [PDF]

open access: yes, 2009
Cilia are microtubule-based structures that protrude from the cell surface and function as sensors for mechanical and chemical environmental cues that regulate cellular differentiation or division. In metazoans, ciliary signaling is important during organismal development and in the homeostasis controls of adult tissues, with receptors for the Hedgehog,
Olga V. Plotnikova   +2 more
openaire   +3 more sources

Primary cilia are lost in preinvasive and invasive prostate cancer. [PDF]

open access: yesPLoS ONE, 2013
Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Little is known about the role of primary cilia in preinvasive and invasive prostate cancer.
Nadia B Hassounah   +5 more
doaj   +1 more source

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