The Primary Cilium and Neuronal Migration [PDF]
Cells, 2022 The primary cilium (PC) is a microtubule-based tiny sensory organelle emanating from the centrosome and protruding from the surface of most eukaryotic cells, including neurons.
Julie Stoufflet, Isabelle Caillé
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Compartmentalised cAMP signalling in the primary cilium [PDF]
Frontiers in Physiology, 2023 cAMP is a universal second messenger that relies on precise spatio-temporal regulation to control varied, and often opposing, cellular functions. This is achieved via selective activation of effectors embedded in multiprotein complexes, or signalosomes ...
Ester Paolocci, Manuela Zaccolo
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Neuronal guidance behaviours: the primary cilium perspective [PDF]
Frontiers in Cell and Developmental BiologyThe establishment of functional neuronal circuits critically relies on the ability of developing neurons to accurately sense and integrate a variety of guidance signals from their surrounding environment.
Melody Atkins +2 more
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The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts [PDF]
BMC Molecular and Cell Biology, 2020 Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hub.
Nisha Venugopal +5 more
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Dendritic cell proliferation by primary cilium in atopic dermatitis [PDF]
Frontiers in Molecular Biosciences, 2023 Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s) in
Manami Toriyama +19 more
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Regulation of Primary Cilium Length by O-GlcNAc during Neuronal Development in a Human Neuron Model [PDF]
Cells, 2023 The primary cilium plays critical roles in the homeostasis and development of neurons. Recent studies demonstrate that cilium length is regulated by the metabolic state of cells, as dictated by processes such as glucose flux and O-GlcNAcylation (OGN ...
Jie L. Tian +5 more
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CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration [PDF]
Nature Communications, 2023 Directed cell migration requires sustained cell polarisation. In migrating cortical interneurons, nuclear movements are directed towards the centrosome that organises the primary cilium signalling hub.
Melody Atkins +5 more
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Kinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology [PDF]
Communications BiologyThe dual-specificity tyrosine-phoshorylation-regulated kinase (DYRK) family are multifunctional enzymes crucial for diverse cellular processes, including signaling through the primary cilium. Their dysregulation has been implicated in various cancers and
Melis D. Arslanhan +2 more
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High water intake induces primary cilium elongation in renal tubular cells [PDF]
Kidney Research and Clinical PracticeBackground The primary cilium protrudes from the cell surface and functions as a mechanosensor. Recently, we found that water intake restriction shortens the primary cilia of renal tubular cells, and a blockage of the shortening disturbs the ability of ...
Min Jung Kong +5 more
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The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium [PDF]
Communications BiologyThe efficient transport of proteins into the primary cilium is a crucial step for many signaling pathways. Dysfunction of this process can lead to the disruption of signaling cascades or cilium assembly, resulting in developmental disorders and cancer ...
S. M. Niedziółka +7 more
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