Results 11 to 20 of about 18,376 (272)

Primary cilium and glioblastoma [PDF]

Therapeutic Advances in Medical Oncology, 2018
Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell.
María Álvarez-Satta, Ander Matheu
doaj   +3 more sources

Signaling through the Primary Cilium [PDF]

Frontiers in Cell and Developmental Biology, 2018
The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It
Gabrielle Wheway, Liliya Nazlamova, John T. Hancock   +2 more
doaj   +5 more sources

Enteric neurons show a primary cilium [PDF]

Journal of Cellular and Molecular Medicine, 2012
AbstractThe primary cilium is a non‐motile cilium whose structure is 9+0. It is involved in co‐ordinating cellular signal transduction pathways, developmental processes and tissue homeostasis. Defects in the structure or function of the primary cilium underlie numerous human diseases, collectively termed ciliopathies.
María José Luesma Bartolomé, Irene Cantarero, Tomás Castiella, Mario Soriano‐Navarro, José Manuel García‐Verdugo, Concepción Junquera   +5 more
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Primary cilium and TULP3-dependent ciliary targeting of ACE2 in SARS-CoV-2 tropism. [PDF]

Cell Commun Signal
Du YH, Tung WL, Wu HH, Hong X, Huang AS, Huang R, Zhang Z, Tang QY, Tang BL, Yang XL, de Alwis R, Tan CW, Hor CHH.   +12 more
europepmc   +3 more sources

Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.

PLoS Biology, 2019
The primary cilium is a central signaling hub in cell proliferation and differentiation and is built and disassembled every cell cycle in many animal cells.
Mary Mirvis, Kathleen A Siemers, W James Nelson, Tim P Stearns   +3 more
doaj   +4 more sources

GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration. [PDF]

Sci Adv
Paillard T, Allam A, Doulazmi M, Hautefeuille M, Fouquet C, Sarde L, Stoufflet J, Messaoudi S, Spassky N, Nédélec S, Dusart I, Trembleau A, Isabelle Caillé.   +12 more
europepmc   +2 more sources

Hedgehog pathway, cell cycle, and primary cilium. [PDF]

Cell Death Discov
Zhuang T.
europepmc   +3 more sources

Primary cilium-mediated mechanotransduction in cartilage chondrocytes. [PDF]

Exp Biol Med (Maywood), 2023
Osteoarthritis (OA) is one of the most prevalent joint disorders associated with the degradation of articular cartilage and an abnormal mechanical microenvironment. Mechanical stimuli, including compression, shear stress, stretching strain, osmotic challenge, and the physical properties of the matrix microenvironment, play pivotal roles in the tissue ...
Zhang Y, Tawiah GK, Wu X, Zhang Y, Wang X, Wei X, Qiao X, Zhang Q.   +7 more
europepmc   +3 more sources

Bioinformatics analyses of the proteome of <i>Holothuria tubulosa</i> coelomic fluid and the first evidence of primary cilium in coelomocyte cells. [PDF]

Front Immunol
La Paglia L, Mauro M, Arizza V, Urso A, Simon S, Drahos L, di Stefano V, Luparello C, Vazzana M, Vizzini A.   +9 more
europepmc   +3 more sources

The importance of a single primary cilium [PDF]

Organogenesis, 2013
The centrosome is the main microtubule-organizing center in animal cells, and helps to influence the morphology of the microtubule cytoskeleton in interphase and mitosis. The centrosome also templates the assembly of the primary cilium, and together they serve as a nexus of cell signaling that provide cells with diverse organization, motility, and ...
Moe R. Mahjoub
openalex   +4 more sources