Signaling through the Primary Cilium [PDF]
Frontiers in Cell and Developmental Biology, 2018 The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It
Gabrielle Wheway +2 more
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The Primary Cilium as a Novel Extracellular Sensor in Bone [PDF]
Frontiers in Endocrinology, 2012 Mechanically induced adaptation of bone is required to maintain a healthy skeleton and defects in this process can lead to dramatic changes in bone mass, resulting in bone diseases such as osteoporosis.
David A Hoey +2 more
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Primary cilium and glioblastoma [PDF]
Therapeutic Advances in Medical Oncology, 2018 Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell.
María Álvarez-Satta, Ander Matheu
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Hypothalamic primary cilium: A hub for metabolic homeostasis. [PDF]
Exp Mol Med, 2021 Obesity is a global health problem that is associated with adverse consequences such as the development of metabolic disorders, including cardiovascular disease, neurodegenerative disorders, and type 2 diabetes.
Yang DJ, Hong J, Kim KW.
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A Ciliary View of the Immunological Synapse [PDF]
Cells, 2019 The primary cilium has gone from being a vestigial organelle to a crucial signaling hub of growing interest given the association between a group of human disorders, collectively known as ciliopathies, and defects in its structure or function.
Chiara Cassioli, Cosima T. Baldari
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The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts [PDF]
BMC Molecular and Cell Biology, 2020 Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hub.
Nisha Venugopal +5 more
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Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. [PDF]
PLoS ONE, 2009 Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched ...
Christopher W Wilson +2 more
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High water intake induces primary cilium elongation in renal tubular cells [PDF]
Kidney Research and Clinical PracticeBackground The primary cilium protrudes from the cell surface and functions as a mechanosensor. Recently, we found that water intake restriction shortens the primary cilia of renal tubular cells, and a blockage of the shortening disturbs the ability of ...
Min Jung Kong +5 more
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Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish [PDF]
BMC Biology, 2010 Background In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway.
van Eeden Freek +3 more
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The role of the primary cilium in cancer.
Neoplasma, 2021 As a common lethal disease, cancer is now responsible for the majority of deaths worldwide and has been the single most important barrier to increasing life expectancy in the world. The pathogenesis of cancer has been the key point of cancer therapeutics
Hongtai Cao +3 more
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