Results 21 to 30 of about 29,664 (193)
Ciliary control of adipocyte progenitor cell fate regulates energy storage
Frontiers in Cell and Developmental Biology, 2022 The primary cilium is a cellular sensory organelle found in most cells in our body. This includes adipocyte progenitor cells in our adipose tissue, a complex organ involved in energy storage, endocrine signaling, and thermogenesis.
Sierra R. Scamfer +2 more
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Assembling a primary cilium [PDF]
Current Opinion in Cell Biology, 2013 Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail.
Sehyun, Kim, Brian David, Dynlacht
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Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
Frontiers in Endocrinology, 2022 The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication ...
Marta Pablos +7 more
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CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis
eLife, 2023 The primary cilium plays important roles in regulating cell differentiation, signal transduction, and tissue organization. Dysfunction of the primary cilium can lead to ciliopathies and cancer.
Bo Wang +13 more
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Primary Cilium-Dependent Signaling Mechanisms [PDF]
International Journal of Molecular Sciences, 2017 Primary cilia are hair-like organelles and play crucial roles in vertebrate development, organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory organelle that responds to mechanical stimuli in the micro-environment. A cilium is also a chemosensor that senses chemical signals surrounding a cell.
Pala, Rajasekharreddy +2 more
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BMC Molecular and Cell Biology, 2020 Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hub.
Nisha Venugopal +5 more
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Stem Cell Research, 2020 The primary cilium acts as a sensory organelle with diverse receptors and ion channels to detect extracellular cues and regulate cellular functions, including cell migration.
Mi Nam Lee +7 more
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Enteric neurons show a primary cilium [PDF]
Journal of Cellular and Molecular Medicine, 2012 AbstractThe primary cilium is a non‐motile cilium whose structure is 9+0. It is involved in co‐ordinating cellular signal transduction pathways, developmental processes and tissue homeostasis. Defects in the structure or function of the primary cilium underlie numerous human diseases, collectively termed ciliopathies.
M. LUESMA +5 more
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Single-molecule imaging in the primary cilium. [PDF]
Methods Cell Biol, 2023 The primary cilium is an important signaling organelle critical for normal development and tissue homeostasis. Its small dimensions and complexity necessitate advanced imaging approaches to uncover the molecular mechanisms behind its function. Here, we outline how single-molecule fluorescence microscopy can be used for tracking molecular dynamics and ...
Weiss LE +8 more
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The primary cilium at a glance [PDF]
Journal of Cell Science, 2010 The primary cilium, which was first so named by Sergei Sorokin ([Sorokin, 1968][1]), is a solitary organelle that emanates from the cell surface of most mammalian cell types during growth arrest.
Satir, Peter +2 more
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