Fluid-structure interaction modelling of neighboring tubes with primary cilium analysis [PDF]
Mathematical Biosciences and Engineering, 2023 We have developed a numerical model of two osculating cylindrical elastic renal tubules to investigate the impact of neighboring tubules on the stress applied to a primary cilium.
Nerion Zekaj +2 more
doaj +3 more sources
Factors That Influence Primary Cilium Length [PDF]
Acta medica Okayama, 2011 Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies.
Asanuma, Masato +3 more
core +5 more sources
Polycystin-2 (TRPP2) regulates primary cilium length in LLC-PK1 renal epithelial cells. [PDF]
Front Physiol, 2022 Polycystin-2 (PC2, TRPP2) is a Ca2+ permeable non-selective cation channel whose dysfunction generates autosomal dominant polycystic kidney disease (ADPKD).
Scarinci N +3 more
europepmc +2 more sources
Primary Cilium in Cancer Hallmarks [PDF]
International Journal of Molecular Sciences, 2019 The primary cilium is a solitary, nonmotile and transitory appendage that is present in virtually all mammalian cells. Our knowledge of its ultrastructure and function is the result of more than fifty years of research that has dramatically changed our ...
Lucilla Fabbri, F. Bost, N. Mazure
semanticscholar +7 more sources
Cells, 2020 Cancer associated fibroblasts (CAFs) are central elements of the microenvironment that control tumor development. In breast cancer, CAFs can originate from adipose progenitors (APs).
Pascal Peraldi +3 more
doaj +2 more sources
Galectin 3 Deficiency Alters Chondrocyte Primary Cilium Formation and Exacerbates Cartilage Destruction via Mitochondrial Apoptosis [PDF]
International Journal of Molecular Sciences, 2020 Mechanical overload and aging are the main risk factors of osteoarthritis (OA). Galectin 3 (GAL3) is important in the formation of primary cilia, organelles that are able to sense mechanical stress.
N. Hafsia +9 more
semanticscholar +2 more sources
The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium [PDF]
eLife, 2014 The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of this organelle is poorly understood, even basic mechanisms, such as control of growth and ...
Weiping Wang, Tao Wu, Marc W Kirschner
doaj +3 more sources
The Primary Cilium as a Therapeutic Target in Ocular Diseases [PDF]
Frontiers in Pharmacology, 2020 Primary cilia are microtubule-based cellular structures located on the surfaces of most mammalian cells and play important roles in detecting external stimuli, signal transduction, and cell cycle regulation.
P. Zhou, Jun Zhou
semanticscholar +2 more sources
Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.
PLoS Biology, 2019 The primary cilium is a central signaling hub in cell proliferation and differentiation and is built and disassembled every cell cycle in many animal cells.
Mary Mirvis +3 more
doaj +2 more sources
CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium [PDF]
Cell Reports, 2018 Summary: The centrosome is the main microtubule-organizing center in animal cells and comprises a mother and daughter centriole surrounded by pericentriolar material.
Maren Mönnich +15 more
doaj +5 more sources