Results 41 to 50 of about 4,814,966 (373)
Ciliary control of adipocyte progenitor cell fate regulates energy storage
Frontiers in Cell and Developmental Biology, 2022 The primary cilium is a cellular sensory organelle found in most cells in our body. This includes adipocyte progenitor cells in our adipose tissue, a complex organ involved in energy storage, endocrine signaling, and thermogenesis.
Sierra R. Scamfer +2 more
doaj +1 more source
Journal of Clinical Investigation, 2021 The melanocortin 4 receptor (MC4R) plays a critical role in the long-term regulation of energy homeostasis, and mutations in the MC4R are the most common cause of monogenic obesity.
Yi Wang +7 more
semanticscholar +1 more source
Development, 2021 The mechanisms of vertebrate Hedgehog signaling are linked to the biology of the primary cilium, an antenna-like organelle that projects from the surface of most vertebrate cell types.
Emily K. Ho, T. Stearns
semanticscholar +1 more source
Assembling a primary cilium [PDF]
Current Opinion in Cell Biology, 2013 Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail.
Brian David Dynlacht, Sehyun Kim
openaire +2 more sources
Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
Frontiers in Endocrinology, 2022 The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication ...
Marta Pablos +7 more
doaj +1 more source
Nonreciprocal interactions give rise to fast cilium synchronisation in finite systems [PDF]
Proc. Natl. Acad. Sci. USA 120, e2307279120 (2023), 2023 Motile cilia beat in an asymmetric fashion in order to propel the surrounding fluid. When many cilia are located on a surface, their beating can synchronise such that their phases form metachronal waves. Here, we computationally study a model where each cilium is represented as a spherical particle, moving along a tilted trajectory with a position ...
arxiv +1 more source
Recent advances in understanding assembly of the primary cilium membrane
Faculty Reviews, 2021 Ciliogenesis describes the assembly of cilia in interphase cells. Several hundred proteins have been linked to ciliogenesis, which proceeds through a highly coordinated multistage process at the distal end of centrioles requiring membranes. In this short
Saurabh Shakya, Christopher J Westlake
semanticscholar +1 more source
CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis
eLife, 2023 The primary cilium plays important roles in regulating cell differentiation, signal transduction, and tissue organization. Dysfunction of the primary cilium can lead to ciliopathies and cancer.
Bo Wang +13 more
doaj +1 more source
Cells, 2021 Signaling networks guide stem cells during their lineage specification and terminal differentiation. Primary cilium, an antenna-like protrusion, directly or indirectly plays a significant role in this guidance.
Sila Yanardag, E. Pugacheva
semanticscholar +1 more source
Mechanical Properties of a Primary Cilium As Measured by Resonant Oscillation [PDF]
, 2015 Primary cilia are ubiquitous mammalian cellular substructures implicated in an ever-increasing number of regulatory pathways. The well-established ciliary hypothesis states that physical bending of the cilium (for example, due to fluid flow) initiates ...
Andrew Resnick
openalex +4 more sources