Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System
Advanced Functional Materials, EarlyView.A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim +4 more
wiley +1 more source
Polycystin-2 Is Required for Chondrocyte Mechanotransduction and Traffics to the Primary Cilium in Response to Mechanical Stimulation [PDF]
, 2021 Clare L. Thompson +4 more
openalex +1 more source
The primary cilium conducts chondrocyte mechanotransduction [PDF]
Cilia, 2012 In several cell types fluid-flow deflection of primary cilia initiates a mechanotransduction pathway via polycystin 1 and 2 (PC1/2). In articular cartilage the chondrocyte primary cilium extends into cartilage matrix. Mechanical signals including compression and fluid flow trigger mechanosensitive regulation of matrix synthesis underpinning tissue ...
Wann, AKT +6 more
openaire +1 more source
Bioprinting Organs—Science or Fiction?—A Review From Students to Students
Advanced Healthcare Materials, EarlyView.Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu +18 more
wiley +1 more source
TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium
Cell Reports, 2013 Transforming growth factor β (TGF-β) signaling is regulated by clathrin-dependent endocytosis (CDE) for the control of cellular processes during development and in tissue homeostasis.
Christian Alexandro Clement +10 more
doaj +1 more source
The Primary Cilium as a Complex Signaling Center [PDF]
Current Biology, 2009 Respect for the primary cilium has undergone a remarkable renaissance over the past decade, and it is now thought to be an essential regulator of numerous signaling pathways. The primary cilium's functions range from the movement of cells and fluid, to sensory inputs involved with olfaction and photoreception.
Berbari, Nicolas F. +3 more
openaire +2 more sources
Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling
Advanced Healthcare Materials, EarlyView.A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl +8 more
wiley +1 more source
Nature Communications, 2016 The primary cilium is essential for embryonic development and tissue pattern formation. Here the authors show that PIPKIγ localizes to the basal body of the primary cilium and cooperates with the Joubert Syndrome associated protein INPP5E to regulate the
Qingwen Xu +5 more
doaj +1 more source
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. [PDF]
PLoS ONE, 2009 Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched ...
Christopher W Wilson +2 more
doaj +1 more source
Primary cilia are required for the persistence of memory and stabilization of perineuronal nets
iScience, 2021 Summary: It is well established that the formation of episodic memories requires multiple hippocampal mechanisms operating on different time scales.
Vladimir Jovasevic +7 more
doaj +1 more source