Results 61 to 70 of about 4,814,966 (373)
Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]
, 2014 SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Chapple, JP, Knight, MM, Thompson, CL
core +2 more sources
The Primary Cilium as a Complex Signaling Center [PDF]
Current Biology, 2009 Respect for the primary cilium has undergone a remarkable renaissance over the past decade, and it is now thought to be an essential regulator of numerous signaling pathways. The primary cilium's functions range from the movement of cells and fluid, to sensory inputs involved with olfaction and photoreception.
Berbari, Nicolas F. +3 more
openaire +3 more sources
A cell-autonomous role for primary cilium-mediated signaling in long-range commissural axon guidance. [PDF]
DevelopmentCiliopathies are characterized by the absence or dysfunction of primary cilia. Despite the fact that cognitive impairments are a common feature of ciliopathies, how cilia dysfunction affects neuronal development has not been characterized in detail. Here,
Dumoulin A +3 more
europepmc +2 more sources
Building the primary cilium membrane [PDF]
Cilia, 2012 Ciliogenesis involves coordinated assembly of a microtubule-based axoneme from the mother centriole and vesicular membrane transport and fusion forming a ciliary membrane around the developing axoneme. We, and others have reported that a Rab11-Rab8 cascade functions in ciliogenesis.
Westlake, CJ +5 more
openaire +2 more sources
BioFactors, Volume 48, Issue 6, Page 1226-1249, November/December 2022., 2022 Abstract Ocular allergies are becoming more prevalent as more airborne pollutants, irritants and microbes pervade our environment. Inflammatory and allergic mediators released by dendritic and mast cells within the conjunctiva cause allergic conjunctivitis (AC), a prevalent ocular surface disorder that affects >40% of the world's human population on a ...
Najam A. Sharif
wiley +1 more source
A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis. [PDF]
PLoS ONE, 2014 Primary cilia are specialized, acetylated microtubule-based signaling processes. Cilium assembly is activated by cellular quiescence and requires reconfiguration of microtubules, the actin cytoskeleton, and vesicular trafficking machinery.
Yanhua Rao +3 more
doaj +1 more source
Primary Cilia: The New Face of Craniofacial Research
Biomolecules, 2022 The primary cilium is a solitary, sensory organelle that extends from the surface of nearly every vertebrate cell, including craniofacial cells. This organelle converts chemical and physical external stimuli into intracellular signaling cascades and ...
Emily R. Moore
doaj +1 more source
Primary cilium and its role in tumorigenesis [PDF]
Journal of Zhejiang University (Medical Sciences), 2021 The primary cilium, a sensory organelle that protrudes from the surface of most eukaryotic cells, receives and transduces various critical signals that are essential for normal development and homeostasis. Structural or functional disruption of primary cilia causes a number of human diseases, including cancer.
Yi Sun, Hongmei Mao
openaire +3 more sources
Synchronizing Protein Traffic to the Primary Cilium [PDF]
Frontiers in Genetics, 2019 The primary cilium is able to maintain a specific protein composition, which is critical for its function as a signaling organelle. Here we introduce a system to synchronize biosynthetic trafficking of ciliary proteins that is based on conditional aggregation domains (CADs).
Wladislaw Stroukov +10 more
openaire +5 more sources
Asymmetric motion of magnetically actuated artificial cilia [PDF]
Lab Chip, 2017,17, 3138-3145, 2018 Most microorganisms use hair-like cilia with asymmetric beating to perform vital bio-physical processes. In this paper, we demonstrate a novel fabrication method for creating magnetic artificial cilia capable of such biologically inspired asymmetrical beating pattern essential for creating microfluidic transport in low Reynolds number.
arxiv +1 more source