Results 91 to 100 of about 5,185,837 (206)

Genomic clustering and homology between HET-S and the NWD2 STAND protein in various fungal genomes. [PDF]

PLoS ONE, 2012
BACKGROUND: Prions are infectious proteins propagating as self-perpetuating amyloid polymers. The [Het-s] prion of Podospora anserina is involved in a cell death process associated with non-self recognition. The prion forming domain (PFD) of HET-s adopts
Asen Daskalov, Mathieu Paoletti, Frédérique Ness, Sven J Saupe   +3 more
doaj   +1 more source

DreamFold: A World Model to efficiently generate protein folding pathways in the latent space

Protein Science, Volume 35, Issue 11, November 2026.
Abstract While there is an abundance of static data for the structure of biological macromolecules, the data regarding their folding mechanisms and dynamics is scarce, posing a challenge to the training of AI models. The World Model approach, which has been very successful in robotics, can come in handy in this regard. From limited data, it can build a
Alan Ianeselli, Jewon Im, Eddie Cavallin, Mark B. Gerstein   +3 more
wiley   +1 more source

Endogenous Viral Etiology of Prion Diseases [PDF]

, 2009
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are a group of incurable neurodegenerative disorders, including Kuru and Creutzfeldt-Jakob disease in humans, “mad cow” disease in cattle, and scrapie in sheep. This paper
Claudiu I. Bandea
core  

Critical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion protein. [PDF]

PLoS Pathogens, 2013
Prion diseases are fatal infectious neurodegenerative disorders in man and animals associated with the accumulation of the pathogenic isoform PrP(Sc) of the host-encoded prion protein (PrP(c)).
Yuzuru Taguchi, Arla M A Mistica, Tetsuyuki Kitamoto, Hermann M Schätzl   +3 more
doaj   +1 more source

Comments to the “Letter to the Editor” for the manuscript titled “Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease”

Brain Pathology, Volume 36, Issue 6, November 2026.
Beta amyloid diffuse plaques, neurofibrillary tangles and neuritic plaques, are increased in densities at the intermediate stage of Alzheimer's neuropathological change. These pathological changes releasing Pathogen‐Associated Molecular Patterns (PAMPs) and Damage‐Associated Molecular Patterns (DAMPs).
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

The Molecular Pathology of Prion Diseases [PDF]

, 2004
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are a group of invariably fatal neurodegenerative disorders. Uniquely, they may present as sporadic, inherited, or infectious forms, all of which involve conversion of the normal ...
Vassallo, Neville, Herms, Jochen, Kretzschmar, Hans A.   +2 more
core  

Prion 2025: advancing the understanding and treatment of prion diseases in dialogue with patients and families

Prion
Prion 2025, held in Armação dos Búzios, Brazil (3–7 November 2025), was the first PRION congress in Latin America and brought together 260 participants from 22 countries.
Tuane C. R. G Vieira, Jerson Lima Silva
doaj   +1 more source

Convergence of Synapses, Endosomes, and Prions in the Biology of Neurodegenerative Diseases

International Journal of Cell Biology, 2013
Age-related misfolding and aggregation of disease-linked proteins in selective brain regions is a characteristic of neurodegenerative diseases. Although neuropathological aggregates that characterize these various diseases are found at sites other than ...
Gunnar K. Gouras
doaj   +1 more source

Microplastics as Emerging Neurotoxins: Brain Accumulation, Neuroinflammation, and Neurodegeneration Risk

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Microplastics and nanoplastics (MPs/NPs) are emerging environmental neurotoxicants capable of accumulating in the human brain through blood‐brain barrier transcytosis and olfactory transport pathways. Once within the central nervous system, MPs/NPs trigger interconnected mechanisms including NLRP3 inflammasome activation, oxidative stress ...
Alfi Sophian, Asmariani, Erika Ismayani
wiley   +1 more source

Modular Metalloprotein Nanowires With Semiconductor‐Scale Conductivity and Tunable Redox Behavior

Small Structures, Volume 7, Issue 10, October 2026.
Conductive protein nanowires are built by aligning three different metalloproteins along an ultrastable filament scaffold. The resulting micrometer‐length nanowires reach conductivities of 1.75 S cm−1. Redox behavior is set by the metalloprotein chosen, while conductivity is governed by the spacing the scaffold imposes, making both independently ...
Nga T. Lam, Lorenzo Travaglini, Yun X. Chen, Dominic J. Glover   +3 more
wiley   +1 more source