Results 81 to 90 of about 5,185,837 (206)

Prion-like Properties in Vesicle Trafficking

, 2023
Vesicle trafficking is an important process critical for secretory and endocytic purposes, but it is also crucial for cell homeostasis, e.g., for maintenance of organelle identity and recycling of membrane components.The endomembrane-located adaptor ...
McKeith Pearson II (11205306)
core   +1 more source

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells [PDF]

Proceedings of the National Academy of Sciences, 2011
Deposition of proteins of aberrant conformation is the hallmark of many neurodegenerative diseases. Misfolding of the normally globular mutant superoxide dismutase-1 (SOD1) is a central, early, but poorly understood event in the pathogenic cascade leading to familial forms of ALS.
Christian, Münch, John, O'Brien, Anne, Bertolotti   +2 more
openaire   +2 more sources

Exogenous prion-like proteins and their potential to trigger cognitive dysfunction

Molecular Systems Biology
The gut is exposed to a wide range of proteins, including ingested proteins and those produced by the resident microbiota. While ingested prion-like proteins can propagate across species, their implications for disease development remain largely unknown.
Jofre Seira Curto, Adan Dominguez Martinez, Genis Perez Collell, Estrella Barniol Simon, Marina Romero Ruiz, Berta Franco Bordés, Paula Sotillo Sotillo, Sandra Villegas Hernandez, Maria Rosario Fernandez, Natalia Sanchez de Groot   +9 more
doaj   +1 more source

Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson’s in vivo models

Life Science Alliance, 2022
This study offers new Caenorhabditis elegans models in which feeding with α-synuclein pre-formed fibrils results in prion-like aggregation of host α-synuclein and dopamine neuron degeneration, and these disease phenotypes are regulated by the heparan ...
Merry Chen, Julie Vincent, Alexis Ezeanii, Saurabh Wakade, Shobha Yerigenahally, Danielle E Mor   +5 more
doaj   +1 more source

α‐Synuclein strain homogeneity in multiple system atrophy subtypes

Brain Pathology, EarlyView.
Two different subtypes of multiple system atrophy are recognized: MSA‐C and MSA‐P. In this manuscript, Lau et al. investigate whether MSA‐C and MSA‐P are caused by different strains of α‐synuclein aggregates. By performing conformational fingerprinting experiments as well as in vitro and in vivo seeding assays, their findings suggest that both MSA‐C ...
Heather H. C. Lau, Nicholas R. G. Silver, Surabhi Mehra, Raphaella W. L. So, Le yao Li, Alison Mao, Erica Stuart, Cian Schmitt‐Ulms, Bradley T. Hyman, Martin Ingelsson, Joel C. Watts   +10 more
wiley   +1 more source

Incentives and motivational crowding to address chronic wasting disease: An experiment with Alberta hunters

Canadian Journal of Agricultural Economics/Revue canadienne d'agroeconomie, EarlyView.
Abstract Behavioral interventions, for example, through the use of incentives and information, are widely used by policymakers to induce welfare‐improving behavior. When these interventions are used in specific contexts such as environmental conservation, individual knowledge, experience, and attitudes can lead to motivational crowding and may limit ...
Lusi Xie, Maik Kecinski, Wiktor Adamowicz   +2 more
wiley   +1 more source

Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions

Translational Neurodegeneration, 2021
Background Accumulation of alpha-synuclein (α-syn) is a main pathological hallmark of Parkinson’s and related diseases, which are collectively known as synucleinopathies. Growing evidence has supported that the same protein can induce remarkably distinct
Di Liu, Jian-Jun Guo, Ji-Hui Su, Alexander Svanbergsson, Lin Yuan, Caroline Haikal, Wen Li, Gunnar Gouras, Jia-Yi Li   +8 more
doaj   +1 more source

Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis

The FEBS Journal, EarlyView.
In this study, we investigate how flow constrictions and shear stress trigger cardiac antibody light chain (AL) fibril formation and deposition. We mimic the mechanical forces exerted by the heart and the microvasculature network using a mini‐peristaltic pump setup and a grid‐type microchannel network, respectively.
Yuji Goto, Keiichi Yamaguchi, Kichitaro Nakajima, Ikuko Yumen, Ruiming He, Hirokazu Matsuda, Tetsuichi Wazawa, Takeharu Nagai, Nobuhiro Tsukada, Suguru Yamamoto, Johannes Buchner, Hirotsugu Ogi   +11 more
wiley   +1 more source

Molecular dynamics as an approach to study prion protein misfolding and the effect of pathogenic mutations [PDF]

, 2011
Computer simulation of protein dynamics offers unique high-resolution information that complements experiment. Using experimentally derived structures of the natively folded prion protein (PrP), physically realistic dynamics and conformational changes ...
Valerie Daggett, Daggett, Valerie, van der Kamp, Marc W, Marc W. van der Kamp   +3 more
core   +1 more source

Characterization of the prion protein in relation to normal cellular function and in disease [PDF]

, 2012
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of rare and fatal neurodegenerative disorders that can affect both human and animals.
Wik, Lotta
core   +1 more source