Results 111 to 120 of about 5,185,837 (206)

Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice. [PDF]

Acta Neuropathol, 2022
Lloyd GM, Sorrentino ZA, Quintin S, Gorion KM, Bell BM, Paterno G, Long B, Prokop S, Giasson BI.   +8 more
europepmc   +1 more source

Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods

Acta Neuropathologica Communications, 2018
The concept that abnormal protein aggregates show prion-like propagation between cells has been considered to explain the onset and progression of many neurodegenerative diseases.
Airi Tarutani, Tetsuaki Arai, Shigeo Murayama, Shin-ichi Hisanaga, Masato Hasegawa   +4 more
doaj   +1 more source

Visualizing α‐synuclein pathology in live brain: A new platform for Parkinson's disease research

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Minhui Yu, Peng Cao
wiley   +1 more source

“Prion-like” seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders

Frontiers in Neuroscience
Intra- or extracellular aggregates of proteins are central pathogenic features in most neurodegenerative disorders. The accumulation of such proteins in diseased brains is believed to be the end-stage of a stepwise aggregation of misfolded monomers to insoluble cross-β fibrils via a series of differently sized soluble oligomers/protofibrils.
Silvia Zampar, Silvia Zampar, Sonja E. Di Gregorio, Sonja E. Di Gregorio, Gustavo Grimmer, Gustavo Grimmer, Joel C. Watts, Joel C. Watts, Martin Ingelsson, Martin Ingelsson, Martin Ingelsson, Martin Ingelsson, Martin Ingelsson   +12 more
openaire   +3 more sources

A rapid dual staining procedure for the quantitative discrimination of prion amyloid from tissues reveals how interactions between amyloid and lipids in tissue homogenates may hinder the detection of prions

, 2009
Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases with no cure to this day, and are often associated with the accumulation of amyloid plaques in the brain and other tissues in affected individuals. The emergence of new
Keevil, C.William, Collin, R., Hervé, R., Secker, Thomas, Pinchin, H.E.   +4 more
core   +1 more source

Different isoforms of the non-integrin laminin receptor are present in mouse brain and bind PrP [PDF]

, 2003
The prion protein (PrP) plays a central role in prion diseases, and identifying its cellular receptor appears to be of crucial interest. We previously showed in the yeast twohybrid system that PrP interacts with the 37 kDa precursor (LRP) of the high ...
S. Weiss, J.-P. Deslys, Weiss, S., D. Dormont, Simoneau, S., S. Simoneau, Deslys, J.-P., Lasmézas, C., S. Haïk, C. Leucht, Haik, S., Leucht, C., Dormont, D., C. Lasmézas   +13 more
core   +2 more sources

Loss of Octarepeats in Two Processed Prion Pseudogenes in the Red Squirrel, Sciurus vulgaris [PDF]

, 2010
The N-terminal region of the mammalian prion protein (PrP) contains an 'octapeptide' repeat which is involved in copper binding. This eight- or nine-residue peptide is repeated four to seven times, depending on the species, and polymorphisms in repeat ...
Rheede, T., Marlinda Hupkes, Timothy T. Kortum, Wilfried W. de Jong, Ole Madsen, de Jong, W.W., Kohlen, W., Madsen, O., Jong, W.W., de, Kortum, T.T., Wouter Kohlen, Teun van Rheede, Hupkes, H.   +12 more
core   +1 more source

Update on human prion disease [PDF]

, 2007
The recognition that variant Creutzfeldt–Jakob disease (vCJD) is caused by the same prion strain as bovine spongiform encephalopathy in cattle has dramatically highlighted the need for a precise understanding of the molecular biology of human prion ...
Wadsworth, Jonathan D.F., Collinge, John
core   +1 more source

[Prion-like Propagation of Pathological α-Synuclein in Vivo].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019
α-Synuclein (αS) is the major component of the filamentous inclusions that constitute the defining characteristic of neurodegenerative synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. αS is deposited in a hyperphosphorylated and ubiquitinated form with a β-sheet-rich fibrillar structure in ...
Masami, Masuda-Suzukake, Masato, Hasegawa   +1 more
openaire   +1 more source

Decontamination of prions, prion-associated amyloid and inefectivity from surgical stainless steel - implications for the risk of iatrogenic transmission of CJD

, 2009
The physicochemical nature of the infectious agent in prion diseases creates asignificant challenge for decontamination services. It has been shown to be both resistant tostandard methods of decontamination, used to inactivate viruses and bacteria, and ...
Howlin, Robert
core   +1 more source