Results 121 to 130 of about 5,185,837 (206)

Editorial: Prion-Like transmission of pathogenic proteins in neurodegenerative diseases: structural and molecular bases

Frontiers in Molecular Biosciences, 2023
Victor Banerjee, Fei Wang, Daniela Sarnataro, Claudio Soto   +3 more
doaj   +1 more source

Papel da proteína prion celular (PrPC) em alterações comportamentais e neuroquímicas associadas ao envelhecimento em camundongo [PDF]

, 2009
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2009.A proteína prion celular (PrPC) é uma glicoproteína ancorada aos neurônios que tem sido ...
Rial, Daniel
core  

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C, MacKay, A, Thompson, AG, Porter, MC, Rudge, P, Collinge, J, Lowe, J, Mead, S, Uphill, J, Lukic, A   +9 more
core  

Characterisation of cytosolic prion protein-mediated putative cytotoxicity in neuronal cell lines [PDF]

, 2007
Prion diseases are a complex group of fatal neurodegenerative disorders with a broad host spectrum, which are characterised by strong neuronal cell loss, spongiform vacuolation and astrocytic proliferation.
Mehlhase, Jana
core  

What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?

, 2013
α-Synuclein is a key protein in Parkinson disease. Not only is it the major protein component of Lewy bodies, but it is implicated in several cellular processes that are disrupted in Parkinson disease.
Dunning, Christopher,, Brundin, Patrik,, George, Sonia,, Lund University.   +3 more
core   +1 more source

Contribution of Multivesicular Bodies to the Prion-Like Propagation of Lesions in Alzheimer’s Disease

, 2011
Alzheimer’s disease (AD) is a chronic developing dementing disease characterized by coexistence of two types of lesions, the parenchymal amyloid deposits and the intraneuronal neurofibrillary tangles. Amyloid deposits are composed of amyloid-beta peptides that derive from sequential cleavages of its precursor named amyloid protein precursor (APP ...
Valerie Vingtdeux, Luc Buee, Nicolas Sergeant   +2 more
openaire   +2 more sources

Anti-prion drugs do not improve survival in novel knock-in models of inherited prion disease.

PLoS Pathogens
Prion diseases uniquely manifest in three distinct forms: inherited, sporadic, and infectious. Wild-type prions are responsible for the sporadic and infectious versions, while mutant prions cause inherited variants like fatal familial insomnia (FFI) and ...
Daniel J Walsh, Judy R Rees, Surabhi Mehra, Matthew E C Bourkas, Lech Kaczmarczyk, Erica Stuart, Walker S Jackson, Joel C Watts, Surachai Supattapone   +8 more
doaj   +1 more source

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection. [PDF]

PLoS One, 2020
Crown A, McAlary L, Fagerli E, Brown H, Yerbury JJ, Galaleldeen A, Cashman NR, Borchelt DR, Ayers JI.   +8 more
europepmc   +1 more source

Die Rolle von PrPC in der neuronalen Differenzierung und die Ausbreitung der infektiösen Isoform PrPSc durch Mikrovesikel [PDF]

, 2008
Prion diseases or transmissible spongiform encephalopathies (TSEs) are rare neurological disorders that may be of genetic or infectious origin, but most frequently occur sporadically in humans. Their outcome is invariably fatal.
Barenco Montrasio, Maria Grazia
core  

Porcine prion protein amyloid

, 2015
Mammalian prions are composed of misfolded aggregated prion protein (PrP) with amyloid-like features. Prions are zoonotic disease agents that infect a wide variety of mammalian species including humans.
Nyström, Sofie,, Hammarström, Per,
core   +1 more source