Results 141 to 150 of about 5,185,837 (206)

Propagation of pathological α-synuclein by a prion-like mechanism

Propagation of pathological α-synuclein by a prion-like mechanism
Intercellular abnormal protein aggregates are a common feature of many neurodegenerative diseases. Misfolded proteins are accumulated in neurons and/or glial cells as a fibriller, phosphorylated and partially ubiquitinated forms. The distribution and spreading of these abnormal proteins in brains of patients are shown to correlate with clinical ...
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Prion-like propagation of alpha-synuclein in reconstructed neural networks

, 2019
Neurodegenerative diseases such as Parkinsons’s or Alzheimer’s diseases are characterized by the aggregation of misfolded proteins in insoluble inclusions. These inclusions trigger cellular dysfnctions and are therefore thought to play an important role in the development of these pathologies.
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Interferon-Stimulated Gene-Mediated Defense Against Prion Infection: Noncanonical Function of Oas1a. [PDF]

Viruses
Homma T, Ishibashi D.
europepmc   +1 more source

Prion-like Protein TDP-43: Mechanisms, Diagnosis, and Therapeutic Prospects. [PDF]

Pathogens
Shimamura MI, Satoh K.
europepmc   +1 more source

Evidence for multiple prion conformers in natural scrapie isolates. [PDF]

PLoS Pathog
Imamura M, Miyazawa K, Okada H, Ohno M, Iguchi H, Matsuura Y, Iwamaru Y, Takatsuki H, Mori T, Ma J, Atarashi R.   +10 more
europepmc   +1 more source

Therapeutic strategies in prion disease: current evidence, translational challenges, and emerging directions. [PDF]

Front Neurosci
Zhu Y, Bradford BM, Mabbott NA.
europepmc   +1 more source

Deletion Analysis of Phase Separation, Amyloid Formation and Prion Propagation by the Intrinsically Disordered Region of Yeast Sup35 Protein. [PDF]

Int J Mol Sci
Grizel AV, Gorsheneva NA, Anee IJ, Paulius K, Kulichikhin KY, Rubel AA, Chernoff YO.   +6 more
europepmc   +1 more source

Cellular prion protein and its derived peptides: multifaceted roles in neurodegenerative diseases and potential as biomarkers. [PDF]

Cell Biosci
Mari E, Aventaggiato M, Paldino E, Ceccarelli S, Mucci N, Bellomo G, Mantuano E, Dugheri S, Martellucci S, Mattei V.   +9 more
europepmc   +1 more source

A scalable, dividing cell model for the robust propagation and quantification of human sporadic Creutzfeldt-Jakob disease prions. [PDF]

Proc Natl Acad Sci U S A
Nihat A, Arora P, Schmidt C, Rayner MLD, Linehan J, Brandner S, Mead S, Collinge J, Jat PS.   +8 more
europepmc   +1 more source

Propagating Sticky Matters: An Update on “Prion‐Like” Templated Misfolding in Neurodegenerative Disorders

Brain Pathology, 2013
Frank Stephan, Tolnay Markus
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