Results 171 to 180 of about 5,185,837 (206)

Rapid generation of prion disease models using AAV-delivered PrP variants in knockout mice. [PDF]

Brain Pathol
San-Juan-Ansoleaga M, Fernández-Muñoz E, Charco JM, Vidal E, Herrero-Martínez D, Galarza-Ahumada J, Sampedro-Torres-Quevedo C, Giler S, Geijo M, González-Aseguinolaza G, Eraña H, Castilla J.   +11 more
europepmc   +1 more source

"S-Tau-Lled" Lysosomes Disrupt Autophagic Processes in Neurodegeneration. [PDF]

Traffic
Bécot A, Kabani M.
europepmc   +1 more source

Camel Prion Disease, Tataouine, Tunisia, 2019-2021. [PDF]

Emerg Infect Dis
Amara A, Di Bari MA, Elmehatli K, Bruno R, Andolsi R, Chiappini B, Vanni I, Esposito E, Riccardi G, Ben Abid OA, Marcon S, Malek A, Ben Smida B, Kessa H, Chandoul W, Handous M, Khorchani R, Nonno R, Zrelli M, Agrimi U, Vaccari G, Pirisinu L.   +21 more
europepmc   +1 more source

Prion Diseases-When Proteins Turn Lethal: Creutzfeldt-Jakob Disease (CJD) and the Quest for Classification, Diagnosis, Therapeutic Approaches, and Emerging Research. [PDF]

Molecules
Ramesh TS, Bartusik-Aebisher D, Dynarowicz K, Aebisher D.   +3 more
europepmc   +1 more source

Prion-like transmission of human tau strains in the mouse brain

Lövestam S, Shimozawa A, Tarutani A, Ohtani R, Masuda-Suzukake M, Hasegawa K, Robinson AC, Saito Y, Murayama S, Yoshida M, Suzuki H, Onaya M, Hasegawa M, Goedert M, Scheres SH.   +14 more
europepmc   +1 more source

From nucleation to widespread propagation: A prion-like concept for ALS

Virus Research, 2015
Propagation of pathological protein assemblies via a prion-like mechanism has been suggested to drive neurodegenerative diseases, such as Parkinson's and Alzheimer's. Recently, amyotrophic lateral sclerosis (ALS)-linked proteins, such as SOD1, TDP-43 and FUS were shown to follow self-perpetuating seeded aggregation, thereby adding ALS to the group of ...
Magdalini Polymenidou
exaly   +5 more sources

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Prion-Like Propagation in Neurodegenerative Diseases

2018
Veerle Baekelandt, Patrik Brundin, WOUTER peelaerts   +2 more
exaly   +2 more sources

C. elegans Models to Study the Propagation of Prions and Prion-Like Proteins [PDF]

Biomolecules, 2020
A hallmark common to many age-related neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), is that patients develop proteinaceous deposits in their central nervous system (CNS).
Carl Alexander Sandhof, Jessica Tittelmeier, Carmen Nussbaum-Krammer   +2 more
exaly   +4 more sources

The prion-like propagation hypothesis in Alzheimer's and Parkinson's disease

Current Opinion in Neurology, 2019
Purpose of review This study, taking the example of Alzheimer's and Parkinson's diseases, presents the experimental and human data that support the hypothesis that Aβ, tau, and α-synuclein may seed and propagate the pathology and consider the potential clinical consequences. Recent findings
Charles, Duyckaerts, Florence, Clavaguera, Marie-Claude, Potier   +2 more
openaire   +2 more sources

The propagation of prion-like protein inclusions in neurodegenerative diseases

Trends in Neurosciences, 2010
The most common neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, are characterized by the misfolding of a small number of proteins that assemble into ordered aggregates in affected brain cells. For many years, the events leading to aggregate formation were believed to be entirely cell-autonomous, with protein ...
Goedert, Michel, Clavaguera, Florence, Tolnay, Markus   +2 more
openaire   +2 more sources