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In Vitro Propagation of the Prion-Like State of Yeast Sup35 Protein
Science, 1997The yeast cytoplasmically inherited genetic determinant [ PSI + ] is presumed to be a manifestation of the prion-like properties of the Sup35 protein (Sup35p). Here, cell-free conversion of Sup35p from [ psi − ] cells (Sup35p psi
S V, Paushkin +3 more
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Prion-like propagation of α-synuclein in neurodegenerative diseases
2019Prions are defined as proteinaceous infectious particles that do not contain nucleic acids. Neuropathological investigations of post-mortem brains and recent studies of experimental transmission have suggested that amyloid-like abnormal protein aggregates, which are the defining feature of many neurodegenerative diseases, behave like prions and ...
Airi, Tarutani, Masato, Hasegawa
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Tau Prion-Like Propagation: State of the Art and Current Challenges
2019It has been almost a decade since the hypothesis of active tau protein propagation in Alzheimer's disease and associated tauopathies was formally raised. We view tau propagation as a cascade of events, starting with early tau misfolding, followed by transfer to another, anatomically connected, cell, contaminating in corruption of endogenous tau in the ...
Simon, Dujardin, Bradley T, Hyman
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2019
The dynamic nature of the tau protein under physiological conditions is likely to be critical for it to perform its diverse functions inside a cell. Under some conditions, this intrinsically disordered protein assembles into pathogenic aggregates that are self-perpetuating, toxic and infectious in nature.
Harish, Kumar, Jayant B, Udgaonkar
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The dynamic nature of the tau protein under physiological conditions is likely to be critical for it to perform its diverse functions inside a cell. Under some conditions, this intrinsically disordered protein assembles into pathogenic aggregates that are self-perpetuating, toxic and infectious in nature.
Harish, Kumar, Jayant B, Udgaonkar
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Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer’s Disease: A Hypothesis
Journal of Molecular Neuroscience, 2018The microtubule-associated protein Tau plays a key role in the neuropathology of Alzheimer's disease by forming intracellular neurofibrillary tangles. Tau in the normal physiological condition helps stabilize microtubules and transport. Tau aggregates due to various gene mutations, intracellular insults and abnormal post-translational modifications ...
Shweta Kishor Sonawane +1 more
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Direct observation of prion-like propagation of protein misfolding templated by pathogenic mutants
Nature Chemical BiologyMany neurodegenerative diseases feature misfolded proteins that propagate via templated conversion of natively folded molecules. However, crucial questions about how such prion-like conversion occurs and what drives it remain unsolved, partly because technical challenges have prevented direct observation of conversion for any protein. We observed prion-
Krishna Neupane +5 more
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Effect of truncation on alpha-synuclein prion-like propagation
Journal of the Neurological Sciences, 2017M. Terada +5 more
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