Results 181 to 190 of about 69,500 (311)

A Practical Framework for GT‐Seq Panel Optimization

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Genotyping‐in‐thousands by sequencing (GT‐seq) panels are powerful tools in ecological, evolutionary and conservation genomics, yet the optimization process critical for robust and reproducible genotyping remains poorly formalized. Here, we present an iterative workflow for GT‐seq panel optimization that emphasizes systematic refinement ...
Chandika RG, Caitlin N. Ott‐Conn, Peter T. Euclide, Julie A. Blanchong, Angela Schmoldt, Randy W. DeYoung, Daniel P. Walsh, Wes A. Larson, Emily K. Latch   +8 more
wiley   +1 more source

Distinct prion conformers from brain and peripheral tissues of gene-targeted mice produce convergent CWD strain properties. [PDF]

PLoS Pathog
DeFranco JP, Atkinson ZN, Crowell J, Shi X, Kim S, Sun JL, Kane SJ, Telling GC.   +7 more
europepmc   +1 more source

From Meat to Plant‐Based Products? The Enduring Impact of BSE on Beef Consumption

Agricultural Economics, Volume 57, Issue 4, July 2026.
ABSTRACT This study reassesses the impact of the historical BSE outbreak on EU diets, showing that consumption patterns shifted persistently even after policy actions eliminated the food safety risk. Utilizing advanced difference‐in‐differences techniques on 1980–2020 data, we demonstrate that while beef consumption exhibited a transient U‐shaped ...
Jader Velásquez, Shon Ferguson
wiley   +1 more source

Prion propagation is controlled by discrete structural regions of PrP rather than overall stability. [PDF]

J Biol Chem
Bhamra SK, Arora P, Liew M, Hosszu LLP, Batchelor M, Clarke AR, Bieschke J, Collinge J, Jat PS.   +8 more
europepmc   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs. [PDF]

PLoS Pathog
Le NTT, Mercer RCC, Fang C, Sundaravadivelu A, Labadorf AT, Lin W, Kwan J, Blum B, Emili A, Harris DA.   +9 more
europepmc   +1 more source

Prion Diseases [PDF]

Microbiology and Immunology, 1995
openaire   +3 more sources

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, Volume 36, Issue 4, July 2026.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Generation of Infectious Prions Amenable to Site-Specific Click Chemistry. [PDF]

ACS Chem Biol
Campbell RG, Iseler JN, Schwind AM, Supattapone S.   +3 more
europepmc   +1 more source

Small critical RNAs in the scrapie agent

, 2009
Unconventional infectious agents cause transmissible spongiform encephalopathy (TSE) diseases including scrapie and bovine spongiform encephalopathy (BSE) in animals and Creutzfeldt-Jakob disease in humans. The protein only hypothesis claims that the TSE
Marie-Madeleine Ruchoux, Jean-Philippe Deslys, Nicolas Vignier, Pierre Lebon, Jean-Guy Fournier, Sophie Freire, Emmanuel Comoy, Steve Simoneau   +7 more
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