Results 101 to 110 of about 10,379,704 (316)
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the pathological aggregation of specific proteins such as amyloid beta (Aβ) and α‐synuclein, respectively. Early detection of these protein aggregates in biological fluids could facilitate timely diagnosis and therapeutic ...
Alexandra Dybala +4 more
wiley +1 more source
A Review on the Salt Bridge Between ASP177 and ARG163 of Wild-Type Rabbit Prion Protein
, 2015 Prion diseases are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species such as sheep and goats, cattle, deer, elks, humans and mice etc., but rabbits have a low susceptibility to be infected ...
Wang, Feng, Zhang, Jiapu
core +2 more sources
Cross infection control measures and the treatment of patients at risk of Creutzfeldt Jakob disease in UK general dental practice [PDF]
, 2001 AIMS: To determine the suitability of key infection control measures currently employed in UK dental practice for delivery of dental care to patients at risk of prion diseases.
A Smith +22 more
core +1 more source
Parkinson's Disease Is Not Simply a Prion Disorder
Journal of Neuroscience, 2017 The notion that prion-like spreading of misfolded α-synuclein (α-SYN) causes Parkinson's disease (PD) has received a great deal of attention. Although attractive in its simplicity, the hypothesis is difficult to reconcile with postmortem analysis of ...
D. Surmeier +4 more
semanticscholar +1 more source
The power of many: when genetics met yeasts and high‐throughput
Biological Reviews, EarlyView.ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley +1 more source
Rinsho Shinkeigaku, 2010 Human prion diseases are classified into 3 categories according to etiologies: idiopathic of unknown cause, acquired of infectious origin, and genetic by PRNP mutation. The surveillance committee have analyzed 2,494 cases and identified 1,402 as prion diseases.
openaire +4 more sources
Prion strains in mammals: Different conformations leading to disease
PLoS Pathogens, 2017 Prion diseases are neurodegenerative disorders affecting mammals with a diverse etiology. Although rare, most of the cases occur spontaneously in humans, with a minority being inherited or acquired by infection.
R. Morales
semanticscholar +1 more source
European Journal of Human Genetics, 2006 Prion diseases have stimulated intense scientific scrutiny since it was proposed that the infectious agent was devoid of nucleic acid. Despite this finding, genetics has played a key role in understanding the pathobiology and clinical aspects of prion disease through the effects of a series of polymorphisms and mutations in the prion protein gene (PRNP)
openaire +2 more sources
A naturally occurring variant of the human prion protein completely prevents prion disease
Nature, 2015 Mammalian prions, transmissible agents causing lethal neurodegenerative diseases, are composed of assemblies of misfolded cellular prion protein (PrP). A novel PrP variant, G127V, was under positive evolutionary selection during the epidemic of kuru—an ...
E. Asante +15 more
semanticscholar +1 more source
International Journal of Cancer, EarlyView.What's New? While treatment strategies for solid brain metastases have been relatively uniform across cancer subtypes, tailored approaches are warranted. In this observational study, intracranial recurrences after microsurgical resection occurred significantly earlier and more frequently at distant sites in patients with triple‐negative breast cancer ...
Jonathan Weller +14 more
wiley +1 more source