Results 111 to 120 of about 51,393 (297)

[Is Parkinson's disease a prion disease?].

Revue neurologique, 2015
The accumulation of a specific protein in aggregated form is a common phenomenon in human neurodegenerative diseases. In Parkinson's disease, this protein is α-synuclein which is a neuronal protein of 143 amino acids. With a monomeric conformation in solution, it also has a natural capacity to aggregate into amyloid structures (dimers, oligomers ...
Brandel, Jean-Philippe, Corbillé, A.-G, Derkinderen, P., Haïk, S   +3 more
openaire   +3 more sources

A study of the incubation period, or age at onset, of the transmissible spongiform encephalopathies/prion diseases. [PDF]

In order to model epidemics of infectious diseases, particularly to estimate probable numbers of cases with onset at any particular time, it is necessaiy to incorporate a term for the incubation period frequency distribution. Sartwell's hypothesis states
Wooldridge, Marion Joan Anstee
core   +1 more source

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)

Phytotherapy Research, EarlyView.
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo, Valeria Mazza, Rosamaria Caminiti, Francesca Oppedisano, Saverio Nucera, Salvatore Ragusa, Sara Ilari, Lucia Carmela Passacatini, Luigi Tucci, Giuseppe Trunfio, Vincenzo Mollace, Carolina Muscoli   +11 more
wiley   +1 more source

Deposition pattern and subcellular distribution of disease-associated prion protein in cerebellar organotypic slice cultures infected with scrapie

Frontiers in Neuroscience, 2015
Organotypic cerebellar slices represent a suitable model for characterizing and manipulating prion replication in complex cell environments. Organotypic slices recapitulate prion pathology and are amenable to drug testing in the absence of a blood-brain ...
Hanna eWolf, Andre eHossinger, Andrea eFehlinger, Sven eBuettner, Valerie eSim, Debbie eMcKenzie, Ina Maja Vorberg, Ina Maja Vorberg   +7 more
doaj   +1 more source

Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom [PDF]

, 2011
The application of genetic breeding programmes to eradicate transmissible spongiform encephalopathies in goats is an important aim for reasons of animal welfare as well as human food safety and food security. Based on the positive impact of Prnp genetics
Bossers, A., Windl, O., González Lorenzo, James Foster, Parnham David, Foster James, Alex Bossers, Ryan, K., Goldmann Wilfred, Ginny Saunders, Xicohtencatl Rosa, Kelly Ryan, Paula Stewart, Wilfred Goldmann, Lorenzo González, Foster, J., David Parnham, Stewart Paula, Goldmann, W., Nora Fernandez, A., B., Rosa Xicohtencatl, Fernandez Nora, Bossers Alex, Parnham, D., Saunders, G., Stewart, P., Xicohtencatl, R., Fernandez, N., Windl Otto, Gonzalez, L., Ryan Kelly, Saunders Ginny, Otto Windl   +33 more
core   +1 more source

Perceived Risks and Agency Trust Associated With Chronic Wasting Disease Over Time 慢性消耗性疾病相关感知风险与机构信任的时序变化研究

Wildlife Letters, EarlyView.
We examined changes in perceived risks associated with chronic wasting disease (CWD) and perceived trust in wildlife agencies over time across 10 studies in eight states. Results indicated that perceived risks to both deer and humans declined the longer the disease had been in a state. Results also indicated that agency trust evaluations were positive,
Jerry J. Vaske, Craig A. Miller
wiley   +1 more source

Effects of Pseudorabies Virus Infection on the Tracheobronchial Lymph Node Transcriptome

Bioinformatics and Biology Insights, 2015
This study represents the first swine transcriptome hive plots created from gene set enrichment analysis (GSEA) data and provides a novel insight into the global transcriptome changes occurring in tracheobronchial lymph nodes (TBLN) and spanning the ...
Laura C. Miller, Darrell O. Bayles, Eraldo L. Zanella, Kelly M. Lager   +3 more
doaj   +1 more source

Decontamination of prions, prion-associated amyloid and inefectivity from surgical stainless steel - implications for the risk of iatrogenic transmission of CJD

, 2009
The physicochemical nature of the infectious agent in prion diseases creates asignificant challenge for decontamination services. It has been shown to be both resistant tostandard methods of decontamination, used to inactivate viruses and bacteria, and ...
Howlin, Robert
core  

Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt-Jakob disease

, 2005
In recent studies, the amyloid form of recombinant prion protein (PrP) encompassing residues 89-230 (rPrP 89-230) produced in vitro induced transmissible prion disease in mice.
Bocharova, O V, Salnikov, V V, Gill, A C, Vadim V. Salnikov, Ilia V. Baskakov, Leonid Breydo, Breydo, L, Olga V. Bocharova, Andrew C. Gill, Baskakov, I V   +9 more
core   +1 more source

Chronic Wasting Disease management responses in North America: A public policy analysis

Wildlife Society Bulletin, EarlyView.
In this study we use the Multiple Streams Framework from public policy theory to assess the responses of wildlife management agencies in states and provinces with CWD‐positive cases in the United States and Canada to alleviate public concerns and manage the spread of this disease.
Kelly H. Dunning, Iree Wheeler, Catherine A. Cummings, Stephen S. Ditchkoff, Braxton McCoy, Daniel Morris, Philip Reichert, Vincent Rivers, Travis E. Stoakley, Temple Stoellinger, Tarissa Spoonhunter, Janna R. Willoughby, Sarah Zohdy   +12 more
wiley   +1 more source