Results 161 to 170 of about 5,604,422 (355)

Localization of the mRNA for a chicken prion protein by in situ hybridization. [PDF]

, 1993
David A. Harris, P. P. Lele, William D. Snider   +2 more
openalex   +1 more source

Upregulation of ST3GAL5 predicts suppression of malignant biological behavior in bladder cancer

UroPrecision, EarlyView.
Abstract Background Bladder cancer (BLCA) is the most prevalent malignancy in the urinary tract system, while ST3GAL5 is a protein‐coding gene that catalyzes the formation of ganglioside monosialodihexosylganglioside 3 (GM3) synthase. GM3 synthase has been reported to significantly influence the malignant process of various cancers.
Song Ou‐Yang, Lei Tang, Lin Li, Yawei Zhao   +3 more
wiley   +1 more source

Reversible symptoms and clearance of mutant prion protein in an inducible model of a genetic prion disease in Drosophila melanogaster

Neurobiology of Disease, 2014
Prion diseases are progressive disorders that affect the central nervous system leading to memory loss, personality changes, ataxia and neurodegeneration.
A. Murali, R.A. Maue, P.J. Dolph
doaj  

Fatal Familial Insomnia, a Prion Disease with a Mutation at Codon 178 of the Prion Protein Gene [PDF]

, 1992
Rossella Medori, Hans-Juergen Tritschler, Andréa LeBlanc, Federico Villare, Valeria Manetto, H. Y. Chen, Run Xue, Suzanne M. Leal, Pasquale Montagna, Pietro Cortelli, Paolo Tinuper, Patrizia Avoni, M. Mochi, Agostino Baruzzi, Jean Jaques Hauw, Jürg Ott, E Lugaresi, L. Autilio‐Gambetti, Pierluigi Gambetti   +18 more
openalex   +1 more source

Lessons learned and lingering uncertainties after seven years of chronic wasting disease management in Norway

Wildlife Biology, EarlyView.
Chronic wasting disease (CWD) is well known among cervids in North America. Nevertheless, management faced different types and degrees of uncertainty when CWD was first detected in reindeer Rangifer tarandus in Nordfjella, Norway in 2016. We present a timeline of the efforts to control CWD, and identify how the process, measurement, environmental, and ...
Atle Mysterud, Michael A. Tranulis, Olav Strand, Christer M. Rolandsen   +3 more
wiley   +1 more source

Thermal stability and conformational transitions of scrapie amyloid (prion) protein correlate with infectivity [PDF]

, 1993
Jiri Safar, Peter P. Roller, D. Carleton Gajdusek, Clarence J. Gibbs   +3 more
openalex   +1 more source

Targeted Mutagenesis of the Oligopeptide Repeat Domain of the Yeast Prion Sup35 [PDF]

, 2014
The formation of prions in the baker’s yeast Saccharomyces cerevisiae is determined by amino acid composition rather than the primary sequence of amino acids.
Davis, Emily, Knox, James D.
core   +1 more source

Human and Mouse Alzheimer's Seeds Differentially Affect Amyloid Deposition and Microglia‐Dependent Plaque Response in Aged Mice

Aging Cell, EarlyView.
This study shows that human and mouse brains contain a different pool of strains that differentially affect the formation of Aβ and tau aggregates. Moreover, the murine seeds trigger an unresponsiveness microglial state, which causes the loss of plaque microglial coverage and affects the formation of amyloid plaques, leading to more severe neuritic ...
Juana Andreo‐Lopez, Cristina Nuñez‐Diaz, Kelly Do Huynh, Marie Minh Thu Nguyen, Celia Da Cunha, Francisco J. Cantero‐Molina, Cynthia Campos‐Moreno, Stefania Zimbone, Francesco Bellia, Maria Laura Giuffrida, Laura Trujillo‐Estrada, Juan Antonio Garcia‐Leon, Miriam Bettinetti‐Luque, Nazaret Gamez, Catalina Valdes, Rodrigo Morales, Stefania Forner, Alessandra C. Martini, Antonia Gutierrez, Frank M. LaFerla, David Baglietto‐Vargas   +20 more
wiley   +1 more source

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease

Brain Pathology, EarlyView.
HSV‐1 infection alters MAPT splicing and promotes Tau pathology in neural models of Alzheimer's disease. HSV‐1 infection in brain organoids and neuronal models increase 4R‐MAPT splicing and Tau hyperphosphorylation. HSV‐1 ICP27 is both necessary and sufficient for inducing these changes highlighting the potential role of HSV‐1 in Alzheimer's disease ...
Emmanuel C. Ijezie, Michael J. Miller, Celine Hardy, Ava R. Jarvis, Timothy F. Czajka, Lianna D'Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy, David C. Butler   +9 more
wiley   +1 more source

Human amyotrophic lateral sclerosis/motor neuron disease: The disease‐associated microglial pathway is upregulated while APOE genotype governs risk and survival

Brain Pathology, EarlyView.
ALS/MND‐related inflammation is investigated in the motor cortex and spinal cord by both transcriptomics and immunohistochemistry. This reveals greater inflammation in the spinal cord and highlights the disease‐associated microglial (DAM) phenotype characterized by ApoE, TREM2, and TYROBP.
Bridget A. Ashford, Julie E. Simpson, Charlotte Dawson, Delphine Boche, Johnathan Cooper‐Knock, Paul R. Heath, Daniel Fillingham, Charlie Appleby‐Mallinder, Wenbin Wei, Mark Dunning, J. Robin Highley   +10 more
wiley   +1 more source