Results 121 to 130 of about 36,884 (188)

DL‐3‐n‐Butylphthalide Protects Against PrP106−126‐Induced Neurotoxicity Through NRF2 Signaling and OPA1/DRP1‐Mediated Mitochondrial Dynamics

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
NBP counteracts PrP106‐126‐induced neurotoxicity by activating NRF2 and restoring OPA1/DRP1‐mediated mitochondrial dynamics. It suppresses oxidative stress and preserves mitochondrial function and bioenergetics. These actions support NBP as a promising therapeutic candidate for prion‐related neurodegeneration.
Wei Wu, Xixi Zhang, Mingyue Jiang, Ning Ma   +3 more
wiley   +1 more source

Comparing Prion Proteins Across Species: Is Zebrafish a Useful Model? [PDF]

Mol Neurobiol
Burato A, Legname G.
europepmc   +1 more source

Progress of Immunotherapies in Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Parkinson's disease (PD) is caused by an immune disorder triggered by α‐synuclein, leading to a persistent neuroinflammatory cycle that drives the disease from non‐motor symptoms to the motor stage. Second, it presents active and passive immunotherapy strategies targeting α‐synuclein and their potential in slowing down the disease progression.
Yong Peng, Xu‐hui Kang, Shun‐yu Yao, Xiuli Zhang, Sugimoto Kazuo, Jia Liu, Miao‐qiao Du, Lan‐xin Lin, Dai‐yi Jiang, Quan Chen, Hong Jin   +10 more
wiley   +1 more source

Upregulated PKM2 Protects Dopaminergic Neurons From Oxidative Damage Through Nrf2 Transactivation in an MPTP‐Induced Mouse Model of Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Oxidative stress induced by MPTP promotes hnRNP A1/A2–dependent alternative splicing toward PKM2 in dopaminergic neurons. Elevated PKM2 transactivates Nrf2, enhances antioxidant gene expression, and protects neurons from oxidative damage and degeneration.
Meng Mei, Qian‐qian Miao, Meng‐ke Li, Hao‐ran Wang, Jian‐hua Ding, Gang Hu, Yao Wei   +6 more
wiley   +1 more source

Determination of prion proteins in the diagnosis of Creutzfeldt-Jakob disease using RT-QuIC: A case report from northeastern Colombia [PDF]

Biomedica
Lizarazo J, Vargas AX, Olarte R, Lizarazo DA.   +3 more
europepmc   +1 more source

Amyloid properties of the yeast cell wall protein Toh1 and its interaction with prion proteins Rnq1 and Sup35. [PDF]

Prion, 2019
Sergeeva AV, Sopova JV, Belashova TA, Siniukova VA, Chirinskaite AV, Galkin AP, Zadorsky SP.   +6 more
europepmc   +1 more source

Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review systematically explores exercise as a multi‐target intervention for RBD, highlighting its mechanisms of action and regulatory effects on key pathophysiological processes. ABSTRACT Backgrounds REM sleep behavior disorder (RBD) is a prodromal non‐motor symptom of Parkinson's disease (PD) and other α‐synucleinopathies, affecting approximately ...
Xinhui Qiu, Zihui Wang, Ruixue Xu, Yiying Hu, Weidong Le   +4 more
wiley   +1 more source

Virgin Coconut Oil Attenuates Diabetic Kidney Disease via Gut Microbiota‐Metabolism‐Inflammation Axis Modulation in Type 2 Diabetic Mice

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This study elucidates the multi‐targeted mechanisms of Virgin Coconut Oil (CO) as a dietary intervention for ameliorating Diabetic Kidney Disease (DKD). High‐purity medium‐chain fatty acids (MCFAs, primarily octanoic acid [C8:0] and decanoic acid [C10:0]) in CO significantly remodel the gut microbiota by enriching short‐chain fatty acid (SCFA ...
Keke Shao, Yun Cao, Ruiqi Gao, Xueyun Dong, Xuehui Liu, Hao Xu, Yunhan Xie, Linlin Xu, Jiayuan He, Min Chen, Leilei Zhang, Asmaa Ali, Liang Wu, Pingping Wang   +13 more
wiley   +1 more source

The Effect of Protein Tagging on Aggregation and Phase Separation

Journal of Cellular Biochemistry, Volume 127, Issue 6, June 2026.
ABSTRACT Protein tags are widely used for purification, solubilization, detection, and imaging, yet they can substantially alter protein self‐assembly. This interference is particularly significant for intrinsically disordered proteins and low‐complexity domains, whose aggregation and phase separation are mediated by weak multivalent interactions that ...
Harunobu Saito, Kenji Sugase
wiley   +1 more source

Creutzfeldt‐Jakob‐Like Presentation in Anti‐AMPAR Encephalitis

Annals of Neurology, Volume 99, Issue 6, Page 1466-1467, June 2026.
Kate Durbano, Marie Belley, Delphine Leclercq, Louis Cousyn   +3 more
wiley   +1 more source