Results 141 to 150 of about 1,598,142 (264)

Detection limitations of prion seeding activities in blood samples from patients with sporadic prion disease

open access: yesBMC Neurology
Background Human prion diseases (HPDs) are fatal neurodegenerative disorders characterized by abnormal prion proteins (PrPSc). However, the detection of prion seeding activity in patients with high sensitivity remains challenging.
Toshiaki Nonaka   +3 more
doaj   +1 more source

Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

open access: yesJournal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias   +5 more
wiley   +1 more source

Structural and dynamical properties of central nervous system proteins with pharmaceutical and biotechnological potential. [PDF]

open access: yes, 2010
Neurodegenerative diseases are widespread pathologies of large social impact that include: prion, Alzheimer and Parkinson disease, Huntington chorea and amyotrophic lateral sclerosis.
Stanzione, Francesca
core   +1 more source

Decontamination of prions, prion-associated amyloid and inefectivity from surgical stainless steel - implications for the risk of iatrogenic transmission of CJD

open access: yes, 2009
The physicochemical nature of the infectious agent in prion diseases creates asignificant challenge for decontamination services. It has been shown to be both resistant tostandard methods of decontamination, used to inactivate viruses and bacteria, and ...
Howlin, Robert
core   +1 more source

Tick‐borne diseases in subtropical dairy farming: The role of calf rearing strategies in antibody and antigen prevalence Enfermedades Transmitidas por Garrapatas en la Ganadería Lechera subtropical: El Papel de las Estrategias de Crianza de Terneros en la Prevalencia de Anticuerpos y Antígenos

open access: yesMedical and Veterinary Entomology, EarlyView.
Tropical farmers try to adapt calf‐rearing systems to temperate dairy industry standards. Calves in tick‐infested areas develop stronger immunity to TBD under controlled exposure to ticks. Early tick exposure promotes sustainable management, balancing tick infestation and developing TBD immunity.
Daniela Balseca   +11 more
wiley   +1 more source

Die Rolle von PrPC in der neuronalen Differenzierung und die Ausbreitung der infektiösen Isoform PrPSc durch Mikrovesikel [PDF]

open access: yes, 2008
Prion diseases or transmissible spongiform encephalopathies (TSEs) are rare neurological disorders that may be of genetic or infectious origin, but most frequently occur sporadically in humans. Their outcome is invariably fatal.
Barenco Montrasio, Maria Grazia
core  

Long‐term stability of horizontal bone augmentation at implant sites

open access: yesPeriodontology 2000, EarlyView.
Abstract Horizontal bone augmentation is a fundamental surgical procedure in regenerative implant dentistry. In recent decades, this procedure has evolved, enabling clinicians to achieve predictable and stable horizontal bone augmentation that supports dental implant restorations.
Jia‐Hui Fu   +3 more
wiley   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer   +2 more
wiley   +1 more source

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires   +15 more
wiley   +1 more source

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

open access: yes, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C   +9 more
core  

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