Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk
Annals of Neurology, Volume 100, Issue 4, Page 737-750, October 2026.Objective ATP‐binding cassette transporter A1 (ABCA1) has been associated with Alzheimer's disease (AD), but the mechanisms by which it impacts disease risk are unknown. ABCA1 is known to bind apolipoprotein E (ApoE) and catalyze apolipoprotein lipidation.
Andrés Peña‐Tauber +24 more
wiley +1 more source
CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions
Glia, Volume 74, Issue 10, October 2026.CX3CR1 deficiency promotes microglial migration toward CNS injury. Proteomic profiling reveals altered RHO‐mediated cytoskeletal signaling, while in vivo two‐photon imaging demonstrates increased process extension, velocity, and accumulation of Cx3cr1‐deficient microglia at lesion sites. ABSTRACT Microglia are innate immune cells of the central nervous
Jens Wagner +13 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.Microplastics and nanoplastics (MPs/NPs) are emerging environmental neurotoxicants capable of accumulating in the human brain through blood‐brain barrier transcytosis and olfactory transport pathways. Once within the central nervous system, MPs/NPs trigger interconnected mechanisms including NLRP3 inflammasome activation, oxidative stress ...
Alfi Sophian, Asmariani, Erika Ismayani
wiley +1 more source
Correction: Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity. [PDF]
PLoS Pathog, 2020 Ghirardini E +8 more
europepmc +1 more source
The Exceptions to the Central Dogma of Biology—Bending the Rules and Extending the Scope
Natural Sciences, Volume 6, Issue 4, October 2026.ABSTRACT The central dogma is an organizing framework for how information flows in biological systems. First presented in 1957 by Francis Crick in his talk “On Protein Synthesis” as a fundamental hypothesis of how information is transferred from DNA to proteins but not out of proteins, it is now introduced in cell biology textbooks as three sequential ...
Anat Ben‐Zvi
wiley +1 more source
Understanding and exploiting interactions between cellular proteostasis pathways and infectious prion proteins for therapeutic benefit. [PDF]
Open Biol, 2020 Yakubu UM +3 more
europepmc +1 more source
Modular Metalloprotein Nanowires With Semiconductor‐Scale Conductivity and Tunable Redox Behavior
Small Structures, Volume 7, Issue 10, October 2026.Conductive protein nanowires are built by aligning three different metalloproteins along an ultrastable filament scaffold. The resulting micrometer‐length nanowires reach conductivities of 1.75 S cm−1. Redox behavior is set by the metalloprotein chosen, while conductivity is governed by the spacing the scaffold imposes, making both independently ...
Nga T. Lam +3 more
wiley +1 more source
Papel da proteína prion celular (PrPC) em alterações comportamentais e neuroquímicas associadas ao envelhecimento em camundongo [PDF]
, 2009 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2009.A proteína prion celular (PrPC) é uma glicoproteína ancorada aos neurônios que tem sido ...
Rial, Daniel
core
Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity. [PDF]
PLoS Pathog, 2020 Ghirardini E +8 more
europepmc +1 more source
Nature CommunicationsPrion diseases are a group of rapidly progressing neurodegenerative disorders caused by the misfolding of the endogenous prion protein (PrPC) into a pathogenic form (PrPSc).
Hasier Eraña +18 more
doaj +1 more source