Results 1 to 10 of about 56,806 (329)

Protease-sensitive synthetic prions. [PDF]

PLoS Pathogens, 2010
Prions arise when the cellular prion protein (PrP(C)) undergoes a self-propagating conformational change; the resulting infectious conformer is designated PrP(Sc).
David W Colby, Rachel Wain, Ilia V Baskakov, Giuseppe Legname, Christina G Palmer, Hoang-Oanh B Nguyen, Azucena Lemus, Fred E Cohen, Stephen J DeArmond, Stanley B Prusiner   +9 more
doaj   +3 more sources

Infectious prions in brains and muscles of domestic pigs experimentally challenged with the BSE, scrapie, and CWD agents [PDF]

mBio
Experimental studies suggest that animal species not previously described as naturally infected by prions are susceptible to prion diseases affecting sheep, cattle, and deer.
Francisca Bravo-Risi, Fraser Brydon, Angela Chong, Kane Spicker, Justin J. Greenlee, Glenn Telling, Claudio Soto, Sandra Pritzkow, Marcelo A. Barria, Rodrigo Morales   +9 more
doaj   +2 more sources

Distribution of chronic wasting disease (CWD) prions in tissues from experimentally exposed coyotes (Canis latrans). [PDF]

PLoS ONE
Cervids susceptible to chronic wasting disease (CWD) are sympatric with multiple other animal species that can interact with infectious prions. Several reports have described the susceptibility of other species to CWD prions, or their potential to ...
Nancy Ho, Reece McGinn, Paulina Soto, Terry R Spraker, Justin Fischer, Kurt VerCauteren, Tracy Nichols, Rodrigo Morales   +7 more
doaj   +2 more sources

Administration of L-Type Bovine Spongiform Encephalopathy to Macaques to Evaluate Zoonotic Potential [PDF]

Emerging Infectious Diseases
We administered L-type bovine spongiform encephalopathy prions to macaques to determine their potential for transmission to humans. After 75 months, no clinical symptoms appeared, and prions were undetectable in any tissue by Western blot or ...
Morikazu Imamura, Ken’ichi Hagiwara, Minoru Tobiume, Minako Ohno, Hiromi Iguchi, Hanae Takatsuki, Tsuyoshi Mori, Ryuichiro Atarashi, Hiroaki Shibata, Fumiko Ono   +9 more
doaj   +2 more sources

Prion-Prion Interactions [PDF]

Prion, 2007
The term prion has been used to describe self-replicating protein conformations that can convert other protein molecules of the same primary structure into its prion conformation. Several different proteins have now been found to exist as prions in Saccharomyces cerevisiae. Surprisingly, these heterologous prion proteins have a strong influence on each
Irina L, Derkatch, Susan W, Liebman
openaire   +3 more sources

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

BMC Biology, 2021
Background The microtubule-associated protein tau forms aggregates in different neurodegenerative diseases called tauopathies. Prior work has shown that a single P301L mutation in tau gene, MAPT, can promote alternative tau folding pathways that ...
Sang-Gyun Kang, Zhuang Zhuang Han, Nathalie Daude, Emily McNamara, Serene Wohlgemuth, Laura Molina-Porcel, Jiri G. Safar, Sue-Ann Mok, David Westaway   +8 more
doaj   +1 more source

Innate Immune Status of Glia Modulates Prion Propagation in Early Stage of Infection

Cells, 2023
Prion diseases are progressive neurodegenerative disorders affecting humans and various mammals. The prominent neuropathological change in prion-affected brains is neuroinflammation, histopathologically characterized by reactive gliosis surrounding prion
Sang-Gyun Kang, Chiye Kim, Judd Aiken, Debbie McKenzie   +3 more
doaj   +1 more source

Prions [PDF]

Cold Spring Harbor Protocols, 2017
Infectious proteins (prions) are usually self-templating filamentous protein polymers (amyloids). Yeast prions are genes composed of protein and, like the multiple alleles of DNA-based genes, can have an array of “variants,” each a distinct self-propagating amyloid conformation. Like the lethal mammalian prions and amyloid diseases, yeast prions may be
Dmitry, Kryndushkin, Herman K, Edskes, Frank P, Shewmaker, Reed B, Wickner   +3 more
openaire   +2 more sources

Prions [PDF]

Arquivos de Neuro-Psiquiatria, 1991
Os autores se propõem a revisar alguns aspectos básicos sobre os prions, alertando sobre a possível participação destes na etiologia de algumas enfermidades degenerativas do sistema nervoso.
Godoy, J. M., Skacel, M., Nicaretta, D.H.   +2 more
openaire   +5 more sources

Palliative Care Resource Utilization in Patients with Prion Disease [PDF]

Alzheimers Dement
Day G, Zayat R, Piura Y, Appleby B, Robinson M.   +4 more
europepmc   +3 more sources