Pro12Ala and His447His polymorphisms of PPAR-γ are associated with polycystic ovary syndrome
Reproductive BioMedicine Online, 2009 Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects 4-12% of women of reproductive age, and is specified when two of the three following criteria are present: hyperandrogenism, oligomenorrhoea and polycystic ovary morphology by ultrasonography. PCOS is characterized by infertility, obesity and hyperinsulinaemia.
Bon-Hee, Gu, Kwang-Hyun, Baek
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PLoS ONE, 2012 BackgroundPPARγ and RBP4 are known to regulate lipid and glucose metabolism and insulin resistance. The influences of PPARγ (C1431T and Pro12Ala) and RBP4 (-803GA) polymorphisms on metabolic syndrome in HIV-infected patients receiving anti-retroviral ...
Yuan-Pin Hung +11 more
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Interaction between genes and lifestyle factors on obesity. [PDF]
, 2008 Obesity originates from a failure of the body-weight control systems, which may be affected by changing environmental influences. Basically, the obesity risk depends on two important mutually-interacting factors: (1) genetic variants (single-nucleotide ...
Marti, A. (Amelia) +2 more
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Genetics and Molecular Research, 2015 We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferator-activated receptor gamma (PPARγ) gene are associated with susceptibility to Alzheimer's disease (AD). We conducted a meta-analysis of the associations between the PPARγ Pro12Ala and His447His polymorphisms and AD in subjects.
Y H, Lee, G G, Song
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Pharmacogenetics in Type 2 Diabetes: Potential Implications for Clinical Practice [PDF]
, 2013 Pharmacogenetic research aims to study how genetic variation may influence drug efficacy and/or toxicity; pharmacogenomics expands this quest to the entire genome. Pharmacogenetic findings may help to uncover new drug targets, illuminate pathophysiology,
Florez, Jose Carlos, Huang, Chunmei
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Investigação do polimorfismo pro12ala no gene do receptor ativado por proliferador de Peroxissomo-gama (PPARy) em pacientes com síndrome metabólica [PDF]
, 2014 Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, 2014.Texto parcialmente liberado pelo autor.
Rocha, Renato Marano
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Influence of the body mass and visceral adiposity on glucose metabolism in obese women with Pro12Pro genotype in PPARgamma2 gene. [PDF]
, 2016 Introduction: Glucose metabolism may be altered in obesity and genotype for PPAR 2 can influence this variable. Objective: To evaluate the influence of body mass (BM) and visceral adiposity (VA) in glucose metabolism in morbid obese women with Pro12Pro ...
D'ANDREA, C. L. +7 more
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Association of the Pro12Ala, C161-T polymorphisms in the PPARγ2 gene with obesity in Han nationality of Yunnan Plateau in Southwest China [PDF]
, 2021 Teng Zhang +8 more
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Egyptian Journal of Medical Human Genetics, 2018 Background: Peroxisome Proliferator-Activated Receptor gamma (PPARγ) is a ligand-dependent transcription factor involved in inflammatory process. PPAR-γ gene was mentioned as having a modulating role in the pathological status of sepsis.The present study
Rabah M. Shawky +3 more
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Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. [PDF]
, 2013 ObjectiveWe aimed to identify factors that are independently associated with the metabolic clearance rate of insulin (MCRI) and to examine the association of MCRI with incident type 2 diabetes in nondiabetic Hispanics and African Americans.Research ...
Anderson, Andrea M +10 more
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