Results 201 to 210 of about 2,679,159 (249)

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Cerebral blood flow in conscious rats and implications for therapeutic interventions

Experimental Physiology, EarlyView.
Abstract Cerebral blood flow (CBF) often becomes compromised in patients suffering from cardiovascular diseases, increasing the risk of neurodegenerative disease and vascular dementia. There is an urgent need for treatments to address cardiovascular risk without compromising brain perfusion, yet the impact of many existing treatments on CBF are not ...
Tonja W. Emans, Courtney R. Brighouse, Jack T. Sloan, Fiona D. McBryde   +3 more
wiley   +1 more source

Australian Guideline for the Identification and Management of Hypertension in Children and Adolescents

Journal of Paediatrics and Child Health, EarlyView.
N. G. Larkins, T. Medley, A. Black, K. A. Bolton, S. Chaturvedi, M. Clark, G. M. Gabb, J. P. Glenning, C. Grimes, R. C. Huang, A. Hyland, C. Jeffries‐Stokes, L. Kalman, S. Kaul, S. Kim, S. McTaggart, R. Kowalski, S. X. Li, S. McNab, D. Metz, A. S. Mihailidou, J. Monin, M. Nelson, M. Pathak, D. Roebuck, M. P. Schlaich, R. Sleaby, C. Quinlan, J. P. Mynard   +28 more
wiley   +1 more source

ATP6ap2/(Pro)renin receptor

Shinzo, 2011
openaire   +1 more source

Renin, (pro)renin and receptor: an update

Clinical Science, 2010
PRR [(pro)renin receptor] was named after its biological characteristics, namely the binding of renin and of its inactive precursor prorenin, that triggers intracellular signalling involving ERK (extracellular-signal-regulated kinase) 1/2. However the gene encoding for PRR is named ATP6ap2 (ATPase 6 accessory protein 2) because PRR was initially found ...
Genevieve Nguyen
openaire   +3 more sources

The (pro)renin receptor: A new addition to the renin–angiotensin system?

European Journal of Pharmacology, 2008
The renin-angiotensin system is still incompletely understood. In particular, the function of prorenin, the inactive precursor of renin, is unknown. Yet, prorenin levels are >10-fold higher than renin levels, and prorenin increases even further in subjects with diabetes mellitus displaying microvascular complications.
Batenburg, Wendy, Danser, Jan
openaire   +4 more sources

(Pro)renin and (pro)renin receptor expression during kidney development in neonates [PDF]

European Journal of Pediatrics, 2016
Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and
Tomomasa Terada, Maki Urushihara, Takahiko Saijo, Ryuji Nakagawa, Shoji Kagami   +4 more
openaire   +3 more sources

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The (pro)renin receptor and soluble (pro)renin receptor in choriocarcinoma

Reproduction, 2021
Abstract This study aimed to determine if the (pro)renin receptor (ATP6AP2) changes the cellular profile of choriocarcinomas from cytotrophoblast cells to terminally syncytialised cells and ascertain whether this impacts the invasive potential of choriocarcinoma cells.
Morosin, Saije K., Delforce, Sarah J., Kahl, Richard G. S., de Meaultsart, Celine Corbisier, Lumbers, Eugenie R., Pringle, Kirsty G.   +5 more
openaire   +2 more sources

The (pro)renin receptors

Journal of Molecular Medicine, 2008
Two (pro)renin receptors have been characterized so far, the mannose-6-phosphate receptor (M6P-R) and a specific receptor called (P)RR for (pro)renin receptor. Each receptor controls a different aspect of renin and prorenin metabolism. The M6P-R is a clearance receptor, whereas (P)RR mediates their cellular effects by activating intracellular signaling
Geneviève, Nguyen, Aurélie, Contrepas
openaire   +2 more sources

PLZF and the (pro)renin receptor

Journal of Molecular Medicine, 2008
For many years, angiotensin II with its respective receptors was considered to be the only effector molecule within the renin-angiotensin system. Nevertheless, several studies indicated that renin (the enzyme catalyzing the generation of angiotensin I) and its enzymatically inactive precursor prorenin may have an angiotensin-II-independent (patho ...
Jan H, Schefe, Thomas, Unger, Heiko, Funke-Kaiser   +2 more
openaire   +2 more sources